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- W3205627802 abstract "Dietary factors have important role in modulating the gut microbiome, which in-turn regulates the molecular events in colonic mucosa. The composition and resulting metabolism of the gut microbiome are decisive factors in colorectal cancer (CRC) tumorigenesis. Altered gut microbiome is associated with impaired immune response, and the release of carcinogenic or genotoxic substances which are the major microbiome-induced mechanisms implicated in CRC pathogenesis. Diets low in dietary fibers and phytomolecules as well as high in red meat are important dietary changes which predispose to CRC. Dietary fibers which reach the colon in an undigested form are further metabolized by the gut microbiome into enterocyte friendly metabolites such as short chain fatty acid (SCFA) which provide anti-inflammatory and anti-proliferative effects. Healthy microbiome supported by dietary fibers and phytomolecules could decrease cell proliferation by regulating the epigenetic events which activate proto-oncogenes and oncogenic pathways. Emerging evidence show that predominance of microbes such as Fusobacterium nucleatum can predispose the colonic mucosa to malignant transformation. Dietary and lifestyle modifications have been demonstrated to restrict the growth of potentially harmful opportunistic organisms. Synbiotics can protect the intestinal mucosa by improving immune response and decreasing the production of toxic metabolites, oxidative stress and cell proliferation. In this narrative review, we aim to update the emerging evidence on how diet could modulate the gut microbial composition and revive colonic epithelium. This review highlights the importance of healthy plant-based diet and related supplements in CRC prevention by improving the gut microbiome." @default.
- W3205627802 created "2021-10-25" @default.
- W3205627802 creator A5004689320 @default.
- W3205627802 creator A5006412529 @default.
- W3205627802 creator A5017206877 @default.
- W3205627802 creator A5033579682 @default.
- W3205627802 creator A5039561102 @default.
- W3205627802 creator A5041437377 @default.
- W3205627802 creator A5074068703 @default.
- W3205627802 creator A5087504103 @default.
- W3205627802 date "2021-10-11" @default.
- W3205627802 modified "2023-10-16" @default.
- W3205627802 title "Emerging Evidence on the Effects of Dietary Factors on the Gut Microbiome in Colorectal Cancer" @default.
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