FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3205649265> ?p ?o ?g. }

• W3205649265 endingPage "14" @default.
• W3205649265 startingPage "1" @default.
• W3205649265 abstract "Liver fibrosis, which results from chronic liver injury due to factors such as chronic alcohol consumption, hepatitis virus infections, and immune attacks, is marked by excessive deposition of extracellular matrix (ECM). Resveratrol (Res), a polyphenol phytoalexin, has been demonstrated to show anti-inflammatory, antioxidative, antiproliferative, and chemopreventive activities. In recent years, Res has been found to inhibit liver fibrosis. Enhanced Hippo pathway activation has also been reported to inhibit tumor progression and liver fibrosis. In the present study, the role of the Hippo pathway in mediating the effects of Res on hepatic stellate cells (HSCs) was examined. We found that Res significantly suppresses HSC proliferation, reducing the cell index. Res induced HSC inactivation, reducing collagen deposition and α-smooth muscle actin (α-SMA) expression. In addition, Res contributed to HSC apoptosis, upregulating Bax and downregulating Bcl-2 expression. Notably, the Hippo pathway was involved in the Res-mediated suppression of HSC activation. Res enhanced the activation of the Hippo pathway and reduced yes-associated protein (YAP) and transcriptional coactivator with the PDZ-binding motif (TAZ) expression. Interestingly, the YAP overexpression inhibited Res-induced HSC inactivation and apoptosis. In conclusion, these results demonstrate that Res inhibits HSC activation, at least in part, via the Hippo pathway. The present study indicates a new antifibrotic mechanism of Res and provides novel insights into Hippo-mediated HSC apoptosis and HSC activation in liver fibrosis." @default.
• W3205649265 created "2021-10-25" @default.
• W3205649265 creator A5004786272 @default.
• W3205649265 creator A5053209536 @default.
• W3205649265 creator A5055033908 @default.
• W3205649265 creator A5061182487 @default.
• W3205649265 date "2021-10-13" @default.
• W3205649265 modified "2023-10-15" @default.
• W3205649265 title "Resveratrol Inhibits Hepatic Stellate Cell Activation via the Hippo Pathway" @default.
• W3205649265 cites W1960283802 @default.
• W3205649265 cites W1994190235 @default.
• W3205649265 cites W2001852409 @default.
• W3205649265 cites W2006778392 @default.
• W3205649265 cites W2011699760 @default.
• W3205649265 cites W2060271784 @default.
• W3205649265 cites W2069819211 @default.
• W3205649265 cites W2082709188 @default.
• W3205649265 cites W2104193042 @default.
• W3205649265 cites W2151089147 @default.
• W3205649265 cites W2154530183 @default.
• W3205649265 cites W2176278790 @default.
• W3205649265 cites W2313180687 @default.
• W3205649265 cites W2512544075 @default.
• W3205649265 cites W2554509393 @default.
• W3205649265 cites W2571312914 @default.
• W3205649265 cites W2606216696 @default.
• W3205649265 cites W2758838459 @default.
• W3205649265 cites W2805688147 @default.
• W3205649265 cites W2807682150 @default.
• W3205649265 cites W2902574774 @default.
• W3205649265 cites W2903694223 @default.
• W3205649265 cites W2913445476 @default.
• W3205649265 cites W2942673512 @default.
• W3205649265 cites W2948798639 @default.
• W3205649265 cites W2972714657 @default.
• W3205649265 cites W2981995724 @default.
• W3205649265 cites W2996721164 @default.
• W3205649265 cites W3032175379 @default.
• W3205649265 cites W3088201539 @default.
• W3205649265 cites W3092350193 @default.
• W3205649265 cites W3094690703 @default.
• W3205649265 cites W3111943962 @default.
• W3205649265 cites W3119158007 @default.
• W3205649265 doi "https://doi.org/10.1155/2021/3399357" @default.
• W3205649265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8528611" @default.
• W3205649265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34690551" @default.
• W3205649265 hasPublicationYear "2021" @default.
• W3205649265 type Work @default.
• W3205649265 sameAs 3205649265 @default.
• W3205649265 citedByCount "12" @default.
• W3205649265 countsByYear W32056492652022 @default.
• W3205649265 countsByYear W32056492652023 @default.
• W3205649265 crossrefType "journal-article" @default.
• W3205649265 hasAuthorship W3205649265A5004786272 @default.
• W3205649265 hasAuthorship W3205649265A5053209536 @default.
• W3205649265 hasAuthorship W3205649265A5055033908 @default.
• W3205649265 hasAuthorship W3205649265A5061182487 @default.
• W3205649265 hasBestOaLocation W32056492651 @default.
• W3205649265 hasConcept C134018914 @default.
• W3205649265 hasConcept C142724271 @default.
• W3205649265 hasConcept C172512520 @default.
• W3205649265 hasConcept C176891718 @default.
• W3205649265 hasConcept C185592680 @default.
• W3205649265 hasConcept C190283241 @default.
• W3205649265 hasConcept C2776816829 @default.
• W3205649265 hasConcept C2780559512 @default.
• W3205649265 hasConcept C502942594 @default.
• W3205649265 hasConcept C55493867 @default.
• W3205649265 hasConcept C62112901 @default.
• W3205649265 hasConcept C62478195 @default.
• W3205649265 hasConcept C71924100 @default.
• W3205649265 hasConcept C86803240 @default.
• W3205649265 hasConcept C95444343 @default.
• W3205649265 hasConcept C98274493 @default.
• W3205649265 hasConceptScore W3205649265C134018914 @default.
• W3205649265 hasConceptScore W3205649265C142724271 @default.
• W3205649265 hasConceptScore W3205649265C172512520 @default.
• W3205649265 hasConceptScore W3205649265C176891718 @default.
• W3205649265 hasConceptScore W3205649265C185592680 @default.
• W3205649265 hasConceptScore W3205649265C190283241 @default.
• W3205649265 hasConceptScore W3205649265C2776816829 @default.
• W3205649265 hasConceptScore W3205649265C2780559512 @default.
• W3205649265 hasConceptScore W3205649265C502942594 @default.
• W3205649265 hasConceptScore W3205649265C55493867 @default.
• W3205649265 hasConceptScore W3205649265C62112901 @default.
• W3205649265 hasConceptScore W3205649265C62478195 @default.
• W3205649265 hasConceptScore W3205649265C71924100 @default.
• W3205649265 hasConceptScore W3205649265C86803240 @default.
• W3205649265 hasConceptScore W3205649265C95444343 @default.
• W3205649265 hasConceptScore W3205649265C98274493 @default.
• W3205649265 hasFunder F4320321001 @default.
• W3205649265 hasLocation W32056492651 @default.
• W3205649265 hasLocation W32056492652 @default.
• W3205649265 hasLocation W32056492653 @default.
• W3205649265 hasLocation W32056492654 @default.
• W3205649265 hasOpenAccess W3205649265 @default.
• W3205649265 hasPrimaryLocation W32056492651 @default.
• W3205649265 hasRelatedWork W2041683594 @default.

• next