FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3205652832> ?p ?o ?g. }

• W3205652832 endingPage "171" @default.
• W3205652832 startingPage "160" @default.
• W3205652832 abstract "We investigated the effect of berberine, a natural plant product that can activate AMP-activated protein kinase (AMPK), on Osteoarthritis (OA) development and associated pain in mice.Human primary knee chondrocytes were utilized to investigate how AMPK is activated by berberine. Both global knockout (KO) of AMPKα1 and congenic wild type (WT) mice were subjected to the post-traumatic OA through destabilization of medial meniscus (DMM) surgery. Two weeks after surgery, the mice were randomly divided into two groups with one group receiving berberine chloride daily via drinking water and were sacrificed at 6 and 12 weeks after surgery. OA severity was assessed by histological and histomorphometric analyses of cartilage degradation, synovitis, and osteophyte formation. OA-associated pain behavior was also determined. Immunohistochemistry (IHC) analyses were carried out to examine changes in AMPK signaling.Berberine induced phosphorylation of AMPKα (Thr172) via liver kinase B1 (LKB1), the major upstream kinase of AMPK, in chondrocytes in vitro. Both WT and AMPKα1KO developed OA and associated pain post DMM surgery. However, treatment with berberine significantly reduced severity of OA and associated pain in WT but not AMPKα1KO mice. IHC analysis of WT DMM knee cartilage further revealed that berberine inhibited concomitant loss of expression and phosphorylation of AMPKα and expression of SIRT1 and SIRT3, suggesting an important role of activation of AMPK signaling in mediating beneficial effect of berberine.Berberine acts through AMPK to reduce joint structural damage and pain associated with post-traumatic OA in mice in vivo." @default.
• W3205652832 created "2021-10-25" @default.
• W3205652832 creator A5019135950 @default.
• W3205652832 creator A5027835055 @default.
• W3205652832 creator A5033484403 @default.
• W3205652832 creator A5041517297 @default.
• W3205652832 date "2022-01-01" @default.
• W3205652832 modified "2023-10-11" @default.
• W3205652832 title "Oral administration of berberine limits post-traumatic osteoarthritis development and associated pain via AMP-activated protein kinase (AMPK) in mice" @default.
• W3205652832 cites W1582245657 @default.
• W3205652832 cites W1696260634 @default.
• W3205652832 cites W1850400028 @default.
• W3205652832 cites W1874251201 @default.
• W3205652832 cites W1908273252 @default.
• W3205652832 cites W1965665343 @default.
• W3205652832 cites W1968097552 @default.
• W3205652832 cites W1973698276 @default.
• W3205652832 cites W2002251686 @default.
• W3205652832 cites W2009524387 @default.
• W3205652832 cites W2033473463 @default.
• W3205652832 cites W2041173066 @default.
• W3205652832 cites W2058435889 @default.
• W3205652832 cites W2060951121 @default.
• W3205652832 cites W2071718640 @default.
• W3205652832 cites W2085788584 @default.
• W3205652832 cites W2103340995 @default.
• W3205652832 cites W2125344123 @default.
• W3205652832 cites W2127174807 @default.
• W3205652832 cites W2129224427 @default.
• W3205652832 cites W2137094819 @default.
• W3205652832 cites W2149085285 @default.
• W3205652832 cites W2150551377 @default.
• W3205652832 cites W2164403708 @default.
• W3205652832 cites W2172201406 @default.
• W3205652832 cites W2229794248 @default.
• W3205652832 cites W2367473578 @default.
• W3205652832 cites W2548136148 @default.
• W3205652832 cites W2590689600 @default.
• W3205652832 cites W2625887862 @default.
• W3205652832 cites W2884983596 @default.
• W3205652832 cites W2889947704 @default.
• W3205652832 cites W2924395156 @default.
• W3205652832 cites W2938251405 @default.
• W3205652832 cites W2943770510 @default.
• W3205652832 cites W3002710359 @default.
• W3205652832 cites W3005542517 @default.
• W3205652832 cites W3007507698 @default.
• W3205652832 cites W3011875247 @default.
• W3205652832 cites W3133363934 @default.
• W3205652832 cites W4232024554 @default.
• W3205652832 cites W4232900352 @default.
• W3205652832 cites W613917169 @default.
• W3205652832 doi "https://doi.org/10.1016/j.joca.2021.10.004" @default.
• W3205652832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34687898" @default.
• W3205652832 hasPublicationYear "2022" @default.
• W3205652832 type Work @default.
• W3205652832 sameAs 3205652832 @default.
• W3205652832 citedByCount "16" @default.
• W3205652832 countsByYear W32056528322022 @default.
• W3205652832 countsByYear W32056528322023 @default.
• W3205652832 crossrefType "journal-article" @default.
• W3205652832 hasAuthorship W3205652832A5019135950 @default.
• W3205652832 hasAuthorship W3205652832A5027835055 @default.
• W3205652832 hasAuthorship W3205652832A5033484403 @default.
• W3205652832 hasAuthorship W3205652832A5041517297 @default.
• W3205652832 hasBestOaLocation W32056528321 @default.
• W3205652832 hasConcept C105702510 @default.
• W3205652832 hasConcept C11960822 @default.
• W3205652832 hasConcept C126322002 @default.
• W3205652832 hasConcept C134018914 @default.
• W3205652832 hasConcept C142724271 @default.
• W3205652832 hasConcept C185592680 @default.
• W3205652832 hasConcept C204787440 @default.
• W3205652832 hasConcept C2776164576 @default.
• W3205652832 hasConcept C2776780712 @default.
• W3205652832 hasConcept C2780116568 @default.
• W3205652832 hasConcept C2780124434 @default.
• W3205652832 hasConcept C2780550940 @default.
• W3205652832 hasConcept C55493867 @default.
• W3205652832 hasConcept C71924100 @default.
• W3205652832 hasConcept C97029542 @default.
• W3205652832 hasConcept C98274493 @default.
• W3205652832 hasConceptScore W3205652832C105702510 @default.
• W3205652832 hasConceptScore W3205652832C11960822 @default.
• W3205652832 hasConceptScore W3205652832C126322002 @default.
• W3205652832 hasConceptScore W3205652832C134018914 @default.
• W3205652832 hasConceptScore W3205652832C142724271 @default.
• W3205652832 hasConceptScore W3205652832C185592680 @default.
• W3205652832 hasConceptScore W3205652832C204787440 @default.
• W3205652832 hasConceptScore W3205652832C2776164576 @default.
• W3205652832 hasConceptScore W3205652832C2776780712 @default.
• W3205652832 hasConceptScore W3205652832C2780116568 @default.
• W3205652832 hasConceptScore W3205652832C2780124434 @default.
• W3205652832 hasConceptScore W3205652832C2780550940 @default.
• W3205652832 hasConceptScore W3205652832C55493867 @default.
• W3205652832 hasConceptScore W3205652832C71924100 @default.
• W3205652832 hasConceptScore W3205652832C97029542 @default.
• W3205652832 hasConceptScore W3205652832C98274493 @default.

• next