Matches in SemOpenAlex for { <https://semopenalex.org/work/W3205659506> ?p ?o ?g. }
- W3205659506 endingPage "4208.e8" @default.
- W3205659506 startingPage "4191" @default.
- W3205659506 abstract "To survive, mammalian cells must adapt to environmental challenges. While the cellular response to mild stress has been widely studied, how cells respond to severe stress remains unclear. We show here that under severe hyperosmotic stress, cells enter a transient hibernation-like state in anticipation of recovery. We demonstrate this adaptive pausing response (APR) is a coordinated cellular response that limits ATP supply and consumption through mitochondrial fragmentation and widespread pausing of mRNA translation. This pausing is accomplished by ribosome stalling at translation initiation codons, which keeps mRNAs poised to resume translation upon recovery. We further show that recovery from severe stress involves ISR (integrated stress response) signaling that permits cell cycle progression, resumption of growth, and reversal of mitochondria fragmentation. Our findings indicate that cells can respond to severe stress via a hibernation-like mechanism that preserves vital elements of cellular function under harsh environmental conditions." @default.
- W3205659506 created "2021-10-25" @default.
- W3205659506 creator A5001301469 @default.
- W3205659506 creator A5001618807 @default.
- W3205659506 creator A5008841966 @default.
- W3205659506 creator A5009610277 @default.
- W3205659506 creator A5011530890 @default.
- W3205659506 creator A5014474847 @default.
- W3205659506 creator A5017715895 @default.
- W3205659506 creator A5018341330 @default.
- W3205659506 creator A5035546319 @default.
- W3205659506 creator A5045341331 @default.
- W3205659506 creator A5045963225 @default.
- W3205659506 creator A5053334268 @default.
- W3205659506 creator A5056002233 @default.
- W3205659506 creator A5057234380 @default.
- W3205659506 creator A5058869043 @default.
- W3205659506 creator A5059581169 @default.
- W3205659506 creator A5064330016 @default.
- W3205659506 creator A5065741540 @default.
- W3205659506 creator A5071494660 @default.
- W3205659506 creator A5072725425 @default.
- W3205659506 creator A5077124904 @default.
- W3205659506 creator A5077256593 @default.
- W3205659506 date "2021-10-01" @default.
- W3205659506 modified "2023-10-15" @default.
- W3205659506 title "Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress" @default.
- W3205659506 cites W1230611947 @default.
- W3205659506 cites W1535694102 @default.
- W3205659506 cites W1608233475 @default.
- W3205659506 cites W1931315964 @default.
- W3205659506 cites W1974241302 @default.
- W3205659506 cites W1974363007 @default.
- W3205659506 cites W1975200549 @default.
- W3205659506 cites W1976406898 @default.
- W3205659506 cites W1987419658 @default.
- W3205659506 cites W1998682097 @default.
- W3205659506 cites W2008255393 @default.
- W3205659506 cites W2009880778 @default.
- W3205659506 cites W2018468745 @default.
- W3205659506 cites W2021521297 @default.
- W3205659506 cites W2025071373 @default.
- W3205659506 cites W2027055740 @default.
- W3205659506 cites W2028866472 @default.
- W3205659506 cites W2029304297 @default.
- W3205659506 cites W2036897871 @default.
- W3205659506 cites W2043823611 @default.
- W3205659506 cites W2044855747 @default.
- W3205659506 cites W2048558269 @default.
- W3205659506 cites W2054670584 @default.
- W3205659506 cites W2071849521 @default.
- W3205659506 cites W2079517684 @default.
- W3205659506 cites W2079768195 @default.
- W3205659506 cites W2080666240 @default.
- W3205659506 cites W2082564115 @default.
- W3205659506 cites W2086157203 @default.
- W3205659506 cites W2086561953 @default.
- W3205659506 cites W2088852871 @default.
- W3205659506 cites W2093158584 @default.
- W3205659506 cites W2100472948 @default.
- W3205659506 cites W2102050179 @default.
- W3205659506 cites W2103017472 @default.
- W3205659506 cites W2103581323 @default.
- W3205659506 cites W2106750896 @default.
- W3205659506 cites W2110029236 @default.
- W3205659506 cites W2113980731 @default.
- W3205659506 cites W2124565600 @default.
- W3205659506 cites W2124985265 @default.
- W3205659506 cites W2129183636 @default.
- W3205659506 cites W2133018386 @default.
- W3205659506 cites W2136272779 @default.
- W3205659506 cites W2136804822 @default.
- W3205659506 cites W2144024988 @default.
- W3205659506 cites W2145645723 @default.
- W3205659506 cites W2154160141 @default.
- W3205659506 cites W2160215304 @default.
- W3205659506 cites W2162262059 @default.
- W3205659506 cites W2169694864 @default.
- W3205659506 cites W2175514210 @default.
- W3205659506 cites W2179438025 @default.
- W3205659506 cites W2180760460 @default.
- W3205659506 cites W2262417550 @default.
- W3205659506 cites W2346619804 @default.
- W3205659506 cites W2410169568 @default.
- W3205659506 cites W2427010553 @default.
- W3205659506 cites W2437617258 @default.
- W3205659506 cites W2493194816 @default.
- W3205659506 cites W2511292374 @default.
- W3205659506 cites W2579217144 @default.
- W3205659506 cites W2692479174 @default.
- W3205659506 cites W2762079818 @default.
- W3205659506 cites W2765157849 @default.
- W3205659506 cites W2766936863 @default.
- W3205659506 cites W2767055857 @default.
- W3205659506 cites W2773619484 @default.
- W3205659506 cites W2775215876 @default.
- W3205659506 cites W2782130029 @default.
- W3205659506 cites W2796317691 @default.