FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3205661775> ?p ?o ?g. }

• W3205661775 endingPage "1533" @default.
• W3205661775 startingPage "1533" @default.
• W3205661775 abstract "Collapsin response mediator protein 2 (CRMP2) is an adaptor protein that adds tubulin dimers to the growing tip of a microtubule. First described in neurons, it is now considered a ubiquitous protein that intervenes in processes such as cytoskeletal remodeling, synaptic connection and trafficking of voltage channels. Mounting evidence supports that CRMP2 plays an essential role in neuropathology and, more recently, in cancer. We have previously described a positive correlation between nuclear phosphorylation of CRMP2 and poor prognosis in lung adenocarcinoma patients. In this work, we studied whether this cytoskeleton molding protein is involved in cancer cell migration. To this aim, we evaluated CRMP2 phosphorylation and localization in the extending lamella of lung adenocarcinoma migrating cells using in vitro assays and in vivo confocal microscopy. We demonstrated that constitutive phosphorylation of CRMP2 impaired lamella formation, cell adhesion and oriented migration. In search of a mechanistic explanation of this phenomenon, we discovered that CRMP2 Ser522 phospho-mimetic mutants display unstable tubulin polymers, unable to bind EB1 plus-Tip protein and the cortical actin adaptor IQGAP1. In addition, integrin recycling is defective and invasive structures are less evident in these mutants. Significantly, mouse xenograft tumors of NSCLC expressing CRMP2 phosphorylation mimetic mutants grew significantly less than wild-type tumors. Given the recent development of small molecule inhibitors of CRMP2 phosphorylation to treat neurodegenerative diseases, our results open the door for their use in cancer treatment." @default.
• W3205661775 created "2021-10-25" @default.
• W3205661775 creator A5007284045 @default.
• W3205661775 creator A5034275213 @default.
• W3205661775 creator A5045630896 @default.
• W3205661775 creator A5051564773 @default.
• W3205661775 creator A5064771070 @default.
• W3205661775 date "2021-10-18" @default.
• W3205661775 modified "2023-10-18" @default.
• W3205661775 title "CRMP2 as a Candidate Target to Interfere with Lung Cancer Cell Migration" @default.
• W3205661775 cites W1521626316 @default.
• W3205661775 cites W1587423226 @default.
• W3205661775 cites W1942168971 @default.
• W3205661775 cites W1979426390 @default.
• W3205661775 cites W2002897207 @default.
• W3205661775 cites W2003074738 @default.
• W3205661775 cites W2005805156 @default.
• W3205661775 cites W2026260372 @default.
• W3205661775 cites W2026811262 @default.
• W3205661775 cites W2029773027 @default.
• W3205661775 cites W2037427489 @default.
• W3205661775 cites W2038779618 @default.
• W3205661775 cites W2040279164 @default.
• W3205661775 cites W2044023005 @default.
• W3205661775 cites W2063120457 @default.
• W3205661775 cites W2065378824 @default.
• W3205661775 cites W2071867803 @default.
• W3205661775 cites W2073296942 @default.
• W3205661775 cites W2085929029 @default.
• W3205661775 cites W2092240451 @default.
• W3205661775 cites W2093733233 @default.
• W3205661775 cites W2094625991 @default.
• W3205661775 cites W2105330965 @default.
• W3205661775 cites W2114602831 @default.
• W3205661775 cites W2117692326 @default.
• W3205661775 cites W2136623153 @default.
• W3205661775 cites W2145977550 @default.
• W3205661775 cites W2149098886 @default.
• W3205661775 cites W2169332291 @default.
• W3205661775 cites W2321170268 @default.
• W3205661775 cites W2727071945 @default.
• W3205661775 cites W2739541068 @default.
• W3205661775 cites W2789713330 @default.
• W3205661775 cites W2898136751 @default.
• W3205661775 cites W2924069622 @default.
• W3205661775 cites W3045079220 @default.
• W3205661775 cites W3095296447 @default.
• W3205661775 cites W3114192448 @default.
• W3205661775 cites W3125891490 @default.
• W3205661775 cites W3128646645 @default.
• W3205661775 cites W3156599094 @default.
• W3205661775 cites W3173661158 @default.
• W3205661775 cites W3174729541 @default.
• W3205661775 cites W3194916623 @default.
• W3205661775 doi "https://doi.org/10.3390/biom11101533" @default.
• W3205661775 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8533992" @default.
• W3205661775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34680167" @default.
• W3205661775 hasPublicationYear "2021" @default.
• W3205661775 type Work @default.
• W3205661775 sameAs 3205661775 @default.
• W3205661775 citedByCount "1" @default.
• W3205661775 countsByYear W32056617752022 @default.
• W3205661775 crossrefType "journal-article" @default.
• W3205661775 hasAuthorship W3205661775A5007284045 @default.
• W3205661775 hasAuthorship W3205661775A5034275213 @default.
• W3205661775 hasAuthorship W3205661775A5045630896 @default.
• W3205661775 hasAuthorship W3205661775A5051564773 @default.
• W3205661775 hasAuthorship W3205661775A5064771070 @default.
• W3205661775 hasBestOaLocation W32056617751 @default.
• W3205661775 hasConcept C11960822 @default.
• W3205661775 hasConcept C121608353 @default.
• W3205661775 hasConcept C137738243 @default.
• W3205661775 hasConcept C142669718 @default.
• W3205661775 hasConcept C1491633281 @default.
• W3205661775 hasConcept C183786373 @default.
• W3205661775 hasConcept C20418707 @default.
• W3205661775 hasConcept C502942594 @default.
• W3205661775 hasConcept C54355233 @default.
• W3205661775 hasConcept C55493867 @default.
• W3205661775 hasConcept C78383274 @default.
• W3205661775 hasConcept C84425145 @default.
• W3205661775 hasConcept C86803240 @default.
• W3205661775 hasConcept C95444343 @default.
• W3205661775 hasConceptScore W3205661775C11960822 @default.
• W3205661775 hasConceptScore W3205661775C121608353 @default.
• W3205661775 hasConceptScore W3205661775C137738243 @default.
• W3205661775 hasConceptScore W3205661775C142669718 @default.
• W3205661775 hasConceptScore W3205661775C1491633281 @default.
• W3205661775 hasConceptScore W3205661775C183786373 @default.
• W3205661775 hasConceptScore W3205661775C20418707 @default.
• W3205661775 hasConceptScore W3205661775C502942594 @default.
• W3205661775 hasConceptScore W3205661775C54355233 @default.
• W3205661775 hasConceptScore W3205661775C55493867 @default.
• W3205661775 hasConceptScore W3205661775C78383274 @default.
• W3205661775 hasConceptScore W3205661775C84425145 @default.
• W3205661775 hasConceptScore W3205661775C86803240 @default.
• W3205661775 hasConceptScore W3205661775C95444343 @default.
• W3205661775 hasFunder F4320315062 @default.

• next