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- W3205728625 abstract "<h3></h3> Unilateral renal agenesis (URA) is defined as the one-sided congenital absence of renal tissue resulting from failure of embryonic kidney formation [1] URA is often associated with congenital anomalies of the kidney and urinary tract and extra-renal anomalies, such as cardiac, genital or gastrointestinal malformations. The impaired clinical outcome of those children may be explained by the hyperfiltration hypothesis which implies that children with a solitary functioning kidney are at risk to develop hypertension, proteinuria, and chronic kidney disease. [2] Aim of this paper was to estimate the incidence of URA and associated anomalies in our population. We reviewed 44 consecutive cases of unilateral renal agenesis diagnosed at our hospital in this 28 years (1991-2019) retrospective study During that period 28776 children were evaluated by 56921 renal ultrasonography (RUS). Patient age at diagnosis ranged from newborn to 18 years. There were 23(52%) boys and 21(48%) girls. Our patients were evaluated for urinary tract infection or abdominal pain and during examination for congenital malformations or pathological fetal US. The left kidney was absent in 25(56%) patients and the right kidney was absent in the remaining 19 (44%). Associated genital anomalies were present in 5 (23%) of 21 girls with URA including agensis et hypoplasio uteri, agenesio et polycystic ovarii, vaginal duplicity. One boy (4%) had contralateral hydronephrosis with bladder diverticulum. Ectopic kidney was diagnosed in 15 patients. In our population the frequency of URA was 1 per 1330 births. The most frequent non urinary malformations were genital anomalies among girls. Careful screening should be proposed throughout childhood to detect early signs of glomerular hyperfiltration and prevent its progression to more serious complications. Ultrasound has been effective for early detection of renal and urinary tract anomalies." @default.
- W3205728625 created "2021-10-25" @default.
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- W3205728625 date "2021-10-01" @default.
- W3205728625 modified "2023-09-26" @default.
- W3205728625 title "360 Unilateral renal agenesia : a 28-year single center expirience" @default.
- W3205728625 doi "https://doi.org/10.1136/archdischild-2021-europaediatrics.360" @default.
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