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- W3205770238 endingPage "2921" @default.
- W3205770238 startingPage "2905" @default.
- W3205770238 abstract "The interest in therapeutic monoclonal antibodies (mAbs) has significantly grown in the pharmaceutical industry, exceeding 100 FDA mAbs approved. Although the upstream processing of their industrial production has been significantly improved in the last years, the downstream processing still depends on immobilized protein A affinity chromatography. The high cost, low capacity and short half-life of immobilized protein A chromatography matrices, encouraged the design of alternative short-peptide ligands for mAb purification. Most of these peptides have been obtained by screening combinatorial peptide libraries. These low-cost ligands can be easily produced by solid-phase peptide synthesis and can be immobilized on chromatographic supports, thus obtaining matrices with high capacity and selectivity. Furthermore, matrices with immobilized peptide ligands have longer half-life than those with protein A due to the higher stability of the peptides. In this review the design and synthesis of peptide ligands, their immobilization on chromatographic supports and the evaluation of the affinity supports for their application in mAb purification is described." @default.
- W3205770238 created "2021-10-25" @default.
- W3205770238 creator A5016268787 @default.
- W3205770238 creator A5023160474 @default.
- W3205770238 creator A5027453227 @default.
- W3205770238 creator A5079265956 @default.
- W3205770238 creator A5086265031 @default.
- W3205770238 date "2021-10-19" @default.
- W3205770238 modified "2023-10-06" @default.
- W3205770238 title "Peptide Affinity Chromatography Applied to Therapeutic Antibodies Purification" @default.
- W3205770238 cites W129165853 @default.
- W3205770238 cites W1533207215 @default.
- W3205770238 cites W1549258100 @default.
- W3205770238 cites W1571189194 @default.
- W3205770238 cites W158442311 @default.
- W3205770238 cites W1963256408 @default.
- W3205770238 cites W1965414380 @default.
- W3205770238 cites W1967763427 @default.
- W3205770238 cites W1969959842 @default.
- W3205770238 cites W1971172729 @default.
- W3205770238 cites W1974256928 @default.
- W3205770238 cites W1974830441 @default.
- W3205770238 cites W1977052508 @default.
- W3205770238 cites W1977090192 @default.
- W3205770238 cites W1983035697 @default.
- W3205770238 cites W1995823732 @default.
- W3205770238 cites W1996281263 @default.
- W3205770238 cites W1999959705 @default.
- W3205770238 cites W2000195664 @default.
- W3205770238 cites W2002160447 @default.
- W3205770238 cites W200540413 @default.
- W3205770238 cites W2006446936 @default.
- W3205770238 cites W2008950022 @default.
- W3205770238 cites W2012357886 @default.
- W3205770238 cites W2017008184 @default.
- W3205770238 cites W2019819573 @default.
- W3205770238 cites W2021767514 @default.
- W3205770238 cites W2022257442 @default.
- W3205770238 cites W2023133196 @default.
- W3205770238 cites W2030163787 @default.
- W3205770238 cites W2030522563 @default.
- W3205770238 cites W2039928024 @default.
- W3205770238 cites W2041412145 @default.
- W3205770238 cites W2041719513 @default.
- W3205770238 cites W2055396417 @default.
- W3205770238 cites W2055409724 @default.
- W3205770238 cites W2055708140 @default.
- W3205770238 cites W2058951584 @default.
- W3205770238 cites W2067857141 @default.
- W3205770238 cites W2070360032 @default.
- W3205770238 cites W2071466886 @default.
- W3205770238 cites W2073292063 @default.
- W3205770238 cites W2075982454 @default.
- W3205770238 cites W2080262597 @default.
- W3205770238 cites W2081738580 @default.
- W3205770238 cites W2087013602 @default.
- W3205770238 cites W2090715543 @default.
- W3205770238 cites W2090985526 @default.
- W3205770238 cites W2094954825 @default.
- W3205770238 cites W2095437577 @default.
- W3205770238 cites W2126905278 @default.
- W3205770238 cites W2140106196 @default.
- W3205770238 cites W2144842198 @default.
- W3205770238 cites W2149464124 @default.
- W3205770238 cites W2154912664 @default.
- W3205770238 cites W2159160448 @default.
- W3205770238 cites W2307268104 @default.
- W3205770238 cites W2320556745 @default.
- W3205770238 cites W2327115322 @default.
- W3205770238 cites W2393744292 @default.
- W3205770238 cites W2399373352 @default.
- W3205770238 cites W2414743169 @default.
- W3205770238 cites W2414811256 @default.
- W3205770238 cites W2417625787 @default.
- W3205770238 cites W2444542949 @default.
- W3205770238 cites W2466519308 @default.
- W3205770238 cites W2466809683 @default.
- W3205770238 cites W2474557235 @default.
- W3205770238 cites W2512170992 @default.
- W3205770238 cites W2540858053 @default.
- W3205770238 cites W2621943315 @default.
- W3205770238 cites W2741422363 @default.
- W3205770238 cites W2749679400 @default.
- W3205770238 cites W2768963311 @default.
- W3205770238 cites W2804500936 @default.
- W3205770238 cites W2888400067 @default.
- W3205770238 cites W2895412026 @default.
- W3205770238 cites W2898618373 @default.
- W3205770238 cites W2905655469 @default.
- W3205770238 cites W2908363667 @default.
- W3205770238 cites W2909080906 @default.
- W3205770238 cites W2910036328 @default.
- W3205770238 cites W2920828119 @default.
- W3205770238 cites W2952235124 @default.
- W3205770238 cites W2966366742 @default.
- W3205770238 cites W2974218562 @default.
- W3205770238 cites W2982586377 @default.
- W3205770238 cites W2996053398 @default.