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- W3205773251 abstract "Essential oils (EOs) and Plant extracts have gained much attention due to their antimicrobial activity as well as a flavoring agent. The effectiveness of herbal compounds has regained the interest of academicians and researchers for the fabrication of plant-based medicines as the plant products are without any side effects, no drug resistance, easily degradable and ecofriendly. Cinnamon oil has been widely used these days due to its antimicrobial properties. It limits its use as it suffers from various limitations such as skin irritation, volatility and instability. To overcome these limitations, cinnamon oil nanosponges were fabricated and were incorporated into carbopol gel for topical drug delivery. The cinnamon oil nanosponges were prepared by the emulsion solvent diffusion method. The fabricated nanosponges were evaluated for Fourier transmission infrared studies, particle size, field emission scanning microscopy studies, in vitro dissolution and bacterial studies, stability studies and in vivo studies. Fourier transmission infrared studies confirmed the absence of drug-polymer interactions. Nanosize and spongy spherical shape of nanosponges were confirmed by particle size and field emission scanning microscopy studies. Nanosponges were incorporated into carbopol gel and were evaluated for in vitro dissolution & bacterial studies and in vivo studies. 100% and 80% drug release was observed from the gel (G1) and nanosponge carrier (NS1), respectively. It concludes that as the concentration of polymer (PVA) increases, the percent of drug release was decreased. The prepared carbopol gel incorporating nanosponges was found to be homogenous, consistent and easily spreadable with a pH that complies with skin. In vitro antibacterial study of the nanosponges (NS1, NS2 and NS3) showed remarkable antibacterial activity as compared with corresponding gel formulations (G1, G2 and G3) as seen from the zone of inhibitions. G1 and NS1 were found to be stable for 3 months when stored under room temperature and 2 months (NS1) and 3 months (G1) under accelerated stability conditions. In vitro & In vivo evaluation includes histopathology examination, bacterial count and skin irritation studies of topical gel G1 revealed significant antimicrobial activity with no skin irritation. Thus, nanosponges can be a promising carrier for encapsulation of essential oils as observed from the outcome of the current investigation." @default.
- W3205773251 created "2021-10-25" @default.
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- W3205773251 date "2020-02-03" @default.
- W3205773251 modified "2023-09-26" @default.
- W3205773251 title "Formulation and Characterization of Topical Gel of Cinnamon Oil Nanosponge Carriers" @default.
- W3205773251 hasPublicationYear "2020" @default.
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