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• W3205776429 endingPage "103240" @default.
• W3205776429 startingPage "103240" @default.
• W3205776429 abstract "Unlike all other biological molecules that are degraded and replaced if damaged, DNA must be repaired as chromosomes cannot be replaced. Indeed, DNA endures a wide variety of structural damage that need to be repaired accurately to maintain genomic stability and proper functioning of cells and to prevent mutation leading to disease. Given that the genome is packaged into chromatin within eukaryotic cells, it has become increasingly evident that the chromatin context of DNA both facilitates and regulates DNA repair processes. In this review, we discuss mechanisms involved in removal of histones (chromatin disassembly) from around DNA lesions, by histone chaperones and chromatin remodelers, that promotes accessibility of the DNA repair machinery. We also elaborate on how the deposition of core histones and specific histone variants onto DNA (chromatin assembly) during DNA repair promotes repair processes, the role of histone post translational modifications in these processes and how chromatin structure is reestablished after DNA repair is complete." @default.
• W3205776429 created "2021-10-25" @default.
• W3205776429 creator A5023022347 @default.
• W3205776429 creator A5042369850 @default.
• W3205776429 creator A5043455538 @default.
• W3205776429 date "2021-12-01" @default.
• W3205776429 modified "2023-10-16" @default.
• W3205776429 title "Chaperoning histones at the DNA repair dance" @default.
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