Matches in SemOpenAlex for { <https://semopenalex.org/work/W3205830004> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W3205830004 abstract "Organ transplantation is considered the ideal treatment for some diseases, such as terminal heart failure. Clinical and experimental evidence emphasizes the impact of brain death (BD) on the viability of the organ to be transplanted and highlights the importance of the donor's status in the final results of the transplant. BD affects organ function through several mechanisms, including hemodynamic changes, hormonal changes, and systemic inflammation resulting from the activation of the immune system, characterized by increased release/synthesis of inflammatory mediators, expression of adhesion molecules, and by inflammatory cell infiltrate. Studies confirm the donor's sex as one of the factors that influence the success of organ transplantation and show a worse prognosis in heart transplantation with grafts from women. Female sex hormones participate in modulating the magnitude of the inflammatory response and acute reductions in the concentration of female sex hormones can cause changes in several systems, including the immune system. Importantly, estradiol protects the cardiovascular system against ischemic, inflammatory, and metabolic injuries. Preliminary data indicate an acute reduction in estrogen concentrations and exacerbation of the pulmonary inflammatory process in females after BD. In this context, this thesis aims to describe the effects of female sex hormone modulation on systemic inflammation and organ damage in brain-dead donors. Differences in microcirculatory changes caused by BD and inflammatory mediators between sexes were analyzed. Considering female sex hormones as immunomodulators and the association between severe organ inflammation in female animals after BD with acute estradiol reduction, we investigated the potential therapeutic effects of treatment with 17β-estradiol to mitigate the deleterious process in the heart, lung, and kidney of rats with BD." @default.
- W3205830004 created "2021-10-25" @default.
- W3205830004 creator A5032543763 @default.
- W3205830004 date "2021-10-22" @default.
- W3205830004 modified "2023-09-28" @default.
- W3205830004 title "The role of estradiol in the maintenance of brain-dead organ donors" @default.
- W3205830004 doi "https://doi.org/10.33612/diss.183298445" @default.
- W3205830004 hasPublicationYear "2021" @default.
- W3205830004 type Work @default.
- W3205830004 sameAs 3205830004 @default.
- W3205830004 citedByCount "0" @default.
- W3205830004 crossrefType "dissertation" @default.
- W3205830004 hasAuthorship W3205830004A5032543763 @default.
- W3205830004 hasBestOaLocation W32058300041 @default.
- W3205830004 hasConcept C126322002 @default.
- W3205830004 hasConcept C151730666 @default.
- W3205830004 hasConcept C168444539 @default.
- W3205830004 hasConcept C203014093 @default.
- W3205830004 hasConcept C2776252253 @default.
- W3205830004 hasConcept C2776914184 @default.
- W3205830004 hasConcept C2777014857 @default.
- W3205830004 hasConcept C2777164284 @default.
- W3205830004 hasConcept C2778384902 @default.
- W3205830004 hasConcept C2778426790 @default.
- W3205830004 hasConcept C2778849806 @default.
- W3205830004 hasConcept C2779343474 @default.
- W3205830004 hasConcept C2911091166 @default.
- W3205830004 hasConcept C42407357 @default.
- W3205830004 hasConcept C71315377 @default.
- W3205830004 hasConcept C71924100 @default.
- W3205830004 hasConcept C86803240 @default.
- W3205830004 hasConcept C8891405 @default.
- W3205830004 hasConceptScore W3205830004C126322002 @default.
- W3205830004 hasConceptScore W3205830004C151730666 @default.
- W3205830004 hasConceptScore W3205830004C168444539 @default.
- W3205830004 hasConceptScore W3205830004C203014093 @default.
- W3205830004 hasConceptScore W3205830004C2776252253 @default.
- W3205830004 hasConceptScore W3205830004C2776914184 @default.
- W3205830004 hasConceptScore W3205830004C2777014857 @default.
- W3205830004 hasConceptScore W3205830004C2777164284 @default.
- W3205830004 hasConceptScore W3205830004C2778384902 @default.
- W3205830004 hasConceptScore W3205830004C2778426790 @default.
- W3205830004 hasConceptScore W3205830004C2778849806 @default.
- W3205830004 hasConceptScore W3205830004C2779343474 @default.
- W3205830004 hasConceptScore W3205830004C2911091166 @default.
- W3205830004 hasConceptScore W3205830004C42407357 @default.
- W3205830004 hasConceptScore W3205830004C71315377 @default.
- W3205830004 hasConceptScore W3205830004C71924100 @default.
- W3205830004 hasConceptScore W3205830004C86803240 @default.
- W3205830004 hasConceptScore W3205830004C8891405 @default.
- W3205830004 hasLocation W32058300041 @default.
- W3205830004 hasLocation W320583000410 @default.
- W3205830004 hasLocation W320583000411 @default.
- W3205830004 hasLocation W32058300042 @default.
- W3205830004 hasLocation W32058300043 @default.
- W3205830004 hasLocation W32058300044 @default.
- W3205830004 hasLocation W32058300045 @default.
- W3205830004 hasLocation W32058300046 @default.
- W3205830004 hasLocation W32058300047 @default.
- W3205830004 hasLocation W32058300048 @default.
- W3205830004 hasLocation W32058300049 @default.
- W3205830004 hasOpenAccess W3205830004 @default.
- W3205830004 hasPrimaryLocation W32058300041 @default.
- W3205830004 hasRelatedWork W1571778651 @default.
- W3205830004 hasRelatedWork W2016168268 @default.
- W3205830004 hasRelatedWork W2081570211 @default.
- W3205830004 hasRelatedWork W2589431353 @default.
- W3205830004 hasRelatedWork W2795155943 @default.
- W3205830004 hasRelatedWork W2811363903 @default.
- W3205830004 hasRelatedWork W2989848107 @default.
- W3205830004 hasRelatedWork W3079568987 @default.
- W3205830004 hasRelatedWork W3136031961 @default.
- W3205830004 hasRelatedWork W4287734271 @default.
- W3205830004 isParatext "false" @default.
- W3205830004 isRetracted "false" @default.
- W3205830004 magId "3205830004" @default.
- W3205830004 workType "dissertation" @default.