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- W3205839441 endingPage "166" @default.
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- W3205839441 abstract "Hepatocellular carcinoma (HCC) is the second most common cause of cancer-induced deaths worldwide, and limited therapeutic options are available for patients with advanced disease. Ramucirumab, a monoclonal antibody that blocks the vascular endothelial growth factor (VEGF) receptor-2, is the first biomarker-selected systemic agent with therapeutic efficacy, tolerability, and favorable patient-reported outcomes in patients with advanced HCC and elevated serum α-fetoprotein levels ≥400 ng/mL, who are resistant or intolerant to sorafenib therapy. However, treatment-induced adverse events (AEs), such as hypertension, proteinuria, bleeding, thromboembolism, and gastrointestinal perforation remain challenging and potentially fatal concerns.This review discusses the published or ongoing studies and subgroup analyses on ramucirumab therapy in patients with advanced HCC. We present information on the risks of ramucirumab-induced common or rare AEs and their management.Ramucirumab toxicity secondary to VEGF inhibition is similar to the AEs that are known to be associated with other VEGF-blocking antibodies. Common AEs can be safely treated using conventional measures; however, rare and potentially fatal AEs necessitate close monitoring. With regard to the safety profile, more promising ramucirumab-containing combination therapies are likely to pave the future path for effective HCC treatment." @default.
- W3205839441 created "2021-10-25" @default.
- W3205839441 creator A5012781741 @default.
- W3205839441 creator A5017035850 @default.
- W3205839441 date "2021-10-28" @default.
- W3205839441 modified "2023-09-24" @default.
- W3205839441 title "Safety of ramucirumab treatment in patients with advanced hepatocellular carcinoma and elevated alpha-fetoprotein" @default.
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- W3205839441 doi "https://doi.org/10.1080/14740338.2022.1995353" @default.
- W3205839441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34668832" @default.
- W3205839441 hasPublicationYear "2021" @default.
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