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- W3205858711 endingPage "1047" @default.
- W3205858711 startingPage "1047" @default.
- W3205858711 abstract "Sporadic Alzheimer's Disease (AD) is the most common form of dementia, and its severity is characterized by the progressive formation of tau neurofibrillary tangles along a well-described path through the brain. This spatial progression provides the basis for Braak staging of the pathological progression for AD. Tau protein is a necessary component of AD pathology, and recent studies have found that soluble tau species with selectively, but not extensively, modified epitopes accumulate along the path of disease progression before AD-associated insoluble aggregates form. As such, modified tau may represent a key cellular stressing agent that potentiates selective vulnerability in susceptible neurons during AD progression. Specifically, studies have found that tau phosphorylated at sites such as T181, T231, and S396 may initiate early pathological changes in tau by disrupting proper tau localization, initiating tau oligomerization, and facilitating tau accumulation and extracellular export. Thus, this review elucidates potential mechanisms through which tau post-translational modifications (PTMs) may simultaneously serve as key modulators of the spatial progression observed in AD development and as key instigators of early pathology related to neurodegeneration-relevant cellular dysfunctions." @default.
- W3205858711 created "2021-10-25" @default.
- W3205858711 creator A5025207687 @default.
- W3205858711 creator A5028140357 @default.
- W3205858711 creator A5041694844 @default.
- W3205858711 creator A5067422011 @default.
- W3205858711 date "2021-10-15" @default.
- W3205858711 modified "2023-10-04" @default.
- W3205858711 title "Tau Post-Translational Modifications: Potentiators of Selective Vulnerability in Sporadic Alzheimer’s Disease" @default.
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