Matches in SemOpenAlex for { <https://semopenalex.org/work/W3205864298> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W3205864298 abstract "Lung cancer is the most commonly diagnosed and leading cause of cancer death worldwide. Imidazole derivatives are considered to be good anti-cancer agents. The present study was aimed to investigate the cytotoxicity of a novel uracil derivative N-(2-(3-(tert-butyl)ureido)ethyl)-4-(1H-imidazol-1-yl)benzamide (TBUEIB) in lung cancer cell line A549. The antiproliferative activity of TBUEIB was investigated using MTT, LDH and trypan blue assay. The apoptotic potential was investigated using various staining techniques and further confirmed by DNA fragmentation assay and western blotting. TBUEIB inhibited A549 cells at a dose of 106 µM. The novel compound was found to exert a modulatory effect on apoptotic marker caspase-3 as well as epigenetic regulatory proteins like DNA Methyltransferase 1 (DNMT1). In silico studies with the compound and other epigenetic proteins such as Histone deacetylase (HDAC) and ubiquitin-like with PHD (plant homeodomain) and RING (Really Interesting New Gene) finger domains 1(UHRF1) showed good modulatory effects. The overall results obtained in the study conclude that the novel compound TBUEIB has potential anti-cancer activities, mainly by targeting the expression of DNMT1 enzyme, which may have re-activated the major tumor suppressor genes involved in the cell cycle, leading to the apoptosis of the cancer cells. The results also indicate that the compound has more than one target in the epigenetic pathway implying that the compound may be a potential multi-target compound." @default.
- W3205864298 created "2021-10-25" @default.
- W3205864298 creator A5004427071 @default.
- W3205864298 creator A5038660147 @default.
- W3205864298 creator A5049095050 @default.
- W3205864298 creator A5079291750 @default.
- W3205864298 date "2020-01-31" @default.
- W3205864298 modified "2023-09-26" @default.
- W3205864298 title "Novel Imidazole Derivative: Inducing Apoptosis and Epigenetic Modulation in Human Lung Adenocarcinoma Cell Lines." @default.
- W3205864298 hasPublicationYear "2020" @default.
- W3205864298 type Work @default.
- W3205864298 sameAs 3205864298 @default.
- W3205864298 citedByCount "0" @default.
- W3205864298 crossrefType "posted-content" @default.
- W3205864298 hasAuthorship W3205864298A5004427071 @default.
- W3205864298 hasAuthorship W3205864298A5038660147 @default.
- W3205864298 hasAuthorship W3205864298A5049095050 @default.
- W3205864298 hasAuthorship W3205864298A5079291750 @default.
- W3205864298 hasConcept C104317684 @default.
- W3205864298 hasConcept C121608353 @default.
- W3205864298 hasConcept C153911025 @default.
- W3205864298 hasConcept C185592680 @default.
- W3205864298 hasConcept C190283241 @default.
- W3205864298 hasConcept C2778305200 @default.
- W3205864298 hasConcept C31573885 @default.
- W3205864298 hasConcept C41091548 @default.
- W3205864298 hasConcept C43759708 @default.
- W3205864298 hasConcept C502942594 @default.
- W3205864298 hasConcept C54355233 @default.
- W3205864298 hasConcept C552990157 @default.
- W3205864298 hasConcept C55493867 @default.
- W3205864298 hasConcept C64927066 @default.
- W3205864298 hasConcept C81729549 @default.
- W3205864298 hasConcept C86803240 @default.
- W3205864298 hasConcept C96232424 @default.
- W3205864298 hasConceptScore W3205864298C104317684 @default.
- W3205864298 hasConceptScore W3205864298C121608353 @default.
- W3205864298 hasConceptScore W3205864298C153911025 @default.
- W3205864298 hasConceptScore W3205864298C185592680 @default.
- W3205864298 hasConceptScore W3205864298C190283241 @default.
- W3205864298 hasConceptScore W3205864298C2778305200 @default.
- W3205864298 hasConceptScore W3205864298C31573885 @default.
- W3205864298 hasConceptScore W3205864298C41091548 @default.
- W3205864298 hasConceptScore W3205864298C43759708 @default.
- W3205864298 hasConceptScore W3205864298C502942594 @default.
- W3205864298 hasConceptScore W3205864298C54355233 @default.
- W3205864298 hasConceptScore W3205864298C552990157 @default.
- W3205864298 hasConceptScore W3205864298C55493867 @default.
- W3205864298 hasConceptScore W3205864298C64927066 @default.
- W3205864298 hasConceptScore W3205864298C81729549 @default.
- W3205864298 hasConceptScore W3205864298C86803240 @default.
- W3205864298 hasConceptScore W3205864298C96232424 @default.
- W3205864298 hasLocation W32058642981 @default.
- W3205864298 hasOpenAccess W3205864298 @default.
- W3205864298 hasPrimaryLocation W32058642981 @default.
- W3205864298 hasRelatedWork W1591296341 @default.
- W3205864298 hasRelatedWork W1591910346 @default.
- W3205864298 hasRelatedWork W1969975271 @default.
- W3205864298 hasRelatedWork W2004828727 @default.
- W3205864298 hasRelatedWork W2009604514 @default.
- W3205864298 hasRelatedWork W2133367541 @default.
- W3205864298 hasRelatedWork W2176669036 @default.
- W3205864298 hasRelatedWork W2225193452 @default.
- W3205864298 hasRelatedWork W2465269466 @default.
- W3205864298 hasRelatedWork W2523300371 @default.
- W3205864298 hasRelatedWork W2523765732 @default.
- W3205864298 hasRelatedWork W2602864929 @default.
- W3205864298 hasRelatedWork W2669591351 @default.
- W3205864298 hasRelatedWork W2892161456 @default.
- W3205864298 hasRelatedWork W2967914810 @default.
- W3205864298 hasRelatedWork W3041903524 @default.
- W3205864298 hasRelatedWork W3080199553 @default.
- W3205864298 hasRelatedWork W3082555467 @default.
- W3205864298 hasRelatedWork W3118326006 @default.
- W3205864298 hasRelatedWork W595813438 @default.
- W3205864298 isParatext "false" @default.
- W3205864298 isRetracted "false" @default.
- W3205864298 magId "3205864298" @default.
- W3205864298 workType "article" @default.