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- W3205919654 endingPage "1210" @default.
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- W3205919654 abstract "As the global population ages at an unprecedented rate, the burden of neurodegenerative diseases is expected to grow. Given the profound impact illness like dementia exert on individuals and society writ large, researchers, physicians, and scientific organizations have called for increased investigation into their treatment and prevention. Both metformin and aspirin have been associated with improved cognitive outcomes. These agents are related in their ability to stimulate AMP kinase (AMPK). Momordica charantia, another AMPK activator, is a component of traditional medicines and a novel agent for the treatment of cancer. It is also being evaluated as a nootropic agent.This article is a comprehensive review which examines the role of AMPK activation in neuroprotection and the role that AMPK activators may have in the management of dementia and cognitive impairment. It evaluates the interaction of metformin, aspirin, and Momordica charantia, with AMPK, and reviews the literature characterizing these agents' impact on neurodegeneration.We suggest that AMPK activators should be considered for the treatment and prevention of neurodegenerative diseases. We identify multiple areas of future investigation which may have a profound impact on patients worldwide." @default.
- W3205919654 created "2021-10-25" @default.
- W3205919654 creator A5026297206 @default.
- W3205919654 creator A5029136277 @default.
- W3205919654 creator A5075809860 @default.
- W3205919654 date "2021-10-03" @default.
- W3205919654 modified "2023-09-29" @default.
- W3205919654 title "AMPK activators for the prevention and treatment of neurodegenerative diseases" @default.
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