Matches in SemOpenAlex for { <https://semopenalex.org/work/W3205923786> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W3205923786 abstract "Abstract Background: Jiawei Ling Gui Zhu Gan Decoction (JW-LZD) is based on Linggui Zhugan Decoction (LZD) and adds eight traditional Chinese medicines: Codonopsis pilosula, Astragalus membranaceus, Yam, Epimedium, Morinda officinalis, Tangerine Peel, Pinellia ternata and Coix Seed , which can be used for the treatment of obesity in the clinical. However, the pharmacological mechanisms of JW-LZD remain unclear. Methods: In this study, we determined the molecular targets and mechanismsinvolved in obesity treatment through network pharmacological analysis, andmolecular docking technology. Related compounds were obtained from the TCMSP.Oral bioavailability and drug-likeness were screened using pharmacokinetic criteria.Molecular targets were identified in the drug-bank database and compared withobesity disease differential genes with P < 0.05 and ∣ log2FC > 0.5 obtained in theGEO-database to obtain cross genes and construct the TCM compound diseaseregulation network. After constructing PPI, Go, and KEGG analyses, the key activecomponents and target genes were selected. Molecular docking was carried out usingAutoDock, and the best binding target was selected to select the best binding targetfor molecular docking. Results: A total of 248 potential compounds and 30 strongly associated JW-LZDtargets were identified. Pathway enrichment analysis showed that putative JW-LZDtargets mostly participated in adenylate cyclase-activating adrenergic receptorsignaling, adrenergic receptor signaling, regulation of signal receptor activity,coagulation, and other metabolic related biological processes. The molecular dockingresults showed that the key JW-LZD components have good potential to combine withthe target genes ADRB2, ADRA2A, ADRA2C, CHEK1, CHEK2, and DGAT2. Conclusion: JW-LZD could prevent obesity through the molecular mechanisms predicted by network pharmacology, providing a way to develop new combination medicines for obesity." @default.
- W3205923786 created "2021-10-25" @default.
- W3205923786 creator A5007439125 @default.
- W3205923786 creator A5022088702 @default.
- W3205923786 creator A5029905233 @default.
- W3205923786 creator A5043839950 @default.
- W3205923786 creator A5045606172 @default.
- W3205923786 creator A5066405494 @default.
- W3205923786 creator A5077423550 @default.
- W3205923786 date "2021-10-19" @default.
- W3205923786 modified "2023-09-27" @default.
- W3205923786 title "Network pharmacology-based strategy to investigate the molecular target and mechanism of Jiawei Linggui Zhugan decoction in the treatment of obesity" @default.
- W3205923786 doi "https://doi.org/10.21203/rs.3.rs-982978/v1" @default.
- W3205923786 hasPublicationYear "2021" @default.
- W3205923786 type Work @default.
- W3205923786 sameAs 3205923786 @default.
- W3205923786 citedByCount "0" @default.
- W3205923786 crossrefType "posted-content" @default.
- W3205923786 hasAuthorship W3205923786A5007439125 @default.
- W3205923786 hasAuthorship W3205923786A5022088702 @default.
- W3205923786 hasAuthorship W3205923786A5029905233 @default.
- W3205923786 hasAuthorship W3205923786A5043839950 @default.
- W3205923786 hasAuthorship W3205923786A5045606172 @default.
- W3205923786 hasAuthorship W3205923786A5066405494 @default.
- W3205923786 hasAuthorship W3205923786A5077423550 @default.
- W3205923786 hasBestOaLocation W32059237861 @default.
- W3205923786 hasConcept C104317684 @default.
- W3205923786 hasConcept C142724271 @default.
- W3205923786 hasConcept C150194340 @default.
- W3205923786 hasConcept C152724338 @default.
- W3205923786 hasConcept C162317418 @default.
- W3205923786 hasConcept C185592680 @default.
- W3205923786 hasConcept C188947578 @default.
- W3205923786 hasConcept C190409667 @default.
- W3205923786 hasConcept C204787440 @default.
- W3205923786 hasConcept C2777397596 @default.
- W3205923786 hasConcept C2779446555 @default.
- W3205923786 hasConcept C2780035454 @default.
- W3205923786 hasConcept C2911069016 @default.
- W3205923786 hasConcept C55493867 @default.
- W3205923786 hasConcept C556039675 @default.
- W3205923786 hasConcept C70721500 @default.
- W3205923786 hasConcept C71924100 @default.
- W3205923786 hasConcept C86803240 @default.
- W3205923786 hasConcept C98274493 @default.
- W3205923786 hasConceptScore W3205923786C104317684 @default.
- W3205923786 hasConceptScore W3205923786C142724271 @default.
- W3205923786 hasConceptScore W3205923786C150194340 @default.
- W3205923786 hasConceptScore W3205923786C152724338 @default.
- W3205923786 hasConceptScore W3205923786C162317418 @default.
- W3205923786 hasConceptScore W3205923786C185592680 @default.
- W3205923786 hasConceptScore W3205923786C188947578 @default.
- W3205923786 hasConceptScore W3205923786C190409667 @default.
- W3205923786 hasConceptScore W3205923786C204787440 @default.
- W3205923786 hasConceptScore W3205923786C2777397596 @default.
- W3205923786 hasConceptScore W3205923786C2779446555 @default.
- W3205923786 hasConceptScore W3205923786C2780035454 @default.
- W3205923786 hasConceptScore W3205923786C2911069016 @default.
- W3205923786 hasConceptScore W3205923786C55493867 @default.
- W3205923786 hasConceptScore W3205923786C556039675 @default.
- W3205923786 hasConceptScore W3205923786C70721500 @default.
- W3205923786 hasConceptScore W3205923786C71924100 @default.
- W3205923786 hasConceptScore W3205923786C86803240 @default.
- W3205923786 hasConceptScore W3205923786C98274493 @default.
- W3205923786 hasLocation W32059237861 @default.
- W3205923786 hasOpenAccess W3205923786 @default.
- W3205923786 hasPrimaryLocation W32059237861 @default.
- W3205923786 hasRelatedWork W2280958785 @default.
- W3205923786 hasRelatedWork W2333810885 @default.
- W3205923786 hasRelatedWork W2350453441 @default.
- W3205923786 hasRelatedWork W2361585167 @default.
- W3205923786 hasRelatedWork W2369685549 @default.
- W3205923786 hasRelatedWork W2380147533 @default.
- W3205923786 hasRelatedWork W2383119692 @default.
- W3205923786 hasRelatedWork W3085751988 @default.
- W3205923786 hasRelatedWork W4290465784 @default.
- W3205923786 hasRelatedWork W4386109888 @default.
- W3205923786 isParatext "false" @default.
- W3205923786 isRetracted "false" @default.
- W3205923786 magId "3205923786" @default.
- W3205923786 workType "article" @default.