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- W3205945765 endingPage "7906" @default.
- W3205945765 startingPage "7891" @default.
- W3205945765 abstract "Bacteria are highly adaptive microorganisms that thrive in a wide range of growth conditions via changes in cell morphologies and macromolecular composition. How bacterial morphologies are regulated in diverse environmental conditions is a long-standing question. Regulation of cell size and shape implies control mechanisms that couple the growth and division of bacteria to their cellular environment and macromolecular composition. In the past decade, simple quantitative laws have emerged that connect cell growth to proteomic composition and the nutrient availability. However, the relationships between cell size, shape, and growth physiology remain challenging to disentangle and unifying models are lacking. In this review, we focus on regulatory models of cell size control that reveal the connections between bacterial cell morphology and growth physiology. In particular, we discuss how changes in nutrient conditions and translational perturbations regulate the cell size, growth rate, and proteome composition. Integrating quantitative models with experimental data, we identify the physiological principles of bacterial size regulation, and discuss the optimization strategies of cellular resource allocation for size control." @default.
- W3205945765 created "2021-10-25" @default.
- W3205945765 creator A5018670501 @default.
- W3205945765 creator A5028359228 @default.
- W3205945765 creator A5081876179 @default.
- W3205945765 date "2021-10-30" @default.
- W3205945765 modified "2023-10-17" @default.
- W3205945765 title "Cellular resource allocation strategies for cell size and shape control in bacteria" @default.
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