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- W3205951844 startingPage "6146" @default.
- W3205951844 abstract "Gliomas are the most common malignant brain tumors in adults, characterized by a high proliferation and invasion. The tumor microenvironment is rich in growth-promoting signals and immunomodulatory pathways, which increase the tumor's aggressiveness. In response to hypoxia and glioma therapy, the amounts of adenosine triphosphate (ATP) and adenosine diphosphate (ADP) strongly increase in the extracellular space, and the purinergic signaling is triggered by nucleotides' interaction in P2 receptors. Several cell types are present in the tumor microenvironment and can facilitate tumor growth. In fact, tumor cells can activate platelets by the ADP-P2Y12 engagement, which plays an essential role in the cancer context, protecting tumors from the immune attack and providing molecules that contribute to the growth and maintenance of a rich environment to sustain the protumor cycle. Besides platelets, the P2Y12 receptor is expressed by some tumors, such as renal carcinoma, colon carcinoma, and gliomas, being related to tumor progression. In this context, this review aims to depict the glioma microenvironment, focusing on the relationship between platelets and tumor malignancy." @default.
- W3205951844 created "2021-10-25" @default.
- W3205951844 creator A5010357851 @default.
- W3205951844 creator A5017051123 @default.
- W3205951844 creator A5065573740 @default.
- W3205951844 creator A5083430117 @default.
- W3205951844 date "2021-10-12" @default.
- W3205951844 modified "2023-10-16" @default.
- W3205951844 title "P2Y12 Purinergic Receptor and Brain Tumors: Implications on Glioma Microenvironment" @default.
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