Matches in SemOpenAlex for { <https://semopenalex.org/work/W3205956875> ?p ?o ?g. }
- W3205956875 endingPage "2705" @default.
- W3205956875 startingPage "2696" @default.
- W3205956875 abstract "Living kidney donors (LKDs) with a family history of renal disease are at risk of kidney disease as compared to LKDs without such history suggesting that some LKDs may be pre-symptomatic for monogenic kidney disease. LKDs with related transplant candidates whose kidney disease was considered genetic in origin were selected for genetic testing. In each case, the transplant candidate was first tested to verify the genetic diagnosis. A genetic diagnosis was confirmed in 12 of 24 transplant candidates (ADPKD-PKD1: 6, ALPORT-COL4A3: 2, ALPORT-COL4A5: 1: nephronophthisis-SDCCAG8: 1; CAKUT-HNF1B and ADTKD-MUC1: 1 each) and 2 had variants of unknown significance (VUS) in phenotype-relevant genes. Focused genetic testing was then done in 20 of 34 LKDs. 12 LKDs screened negative for the familial variant and were permitted to donate; seven screened positive and were counseled against donation. One, the heterozygous carrier of a recessive disorder was also cleared. Six of seven LKDs with a family history of ADPKD were under 30 years and in 5, by excluding ADPKD, allowed donation to safely proceed. The inclusion of genetic testing clarified the diagnosis in recipient candidates, improving safety or informed decision-making in LKDs." @default.
- W3205956875 created "2021-10-25" @default.
- W3205956875 creator A5001930460 @default.
- W3205956875 creator A5014833790 @default.
- W3205956875 creator A5033180014 @default.
- W3205956875 creator A5033543022 @default.
- W3205956875 creator A5036696731 @default.
- W3205956875 creator A5061379662 @default.
- W3205956875 creator A5076415613 @default.
- W3205956875 creator A5086943690 @default.
- W3205956875 creator A5090852510 @default.
- W3205956875 creator A5091131201 @default.
- W3205956875 date "2021-11-03" @default.
- W3205956875 modified "2023-09-27" @default.
- W3205956875 title "Sequential genetic testing of living‐related donors for inherited renal disease to promote informed choice and enhance safety of living donation" @default.
- W3205956875 cites W1722566242 @default.
- W3205956875 cites W1965071252 @default.
- W3205956875 cites W1987266465 @default.
- W3205956875 cites W1999056511 @default.
- W3205956875 cites W2008905653 @default.
- W3205956875 cites W2051978340 @default.
- W3205956875 cites W2097746043 @default.
- W3205956875 cites W2104207260 @default.
- W3205956875 cites W2119513206 @default.
- W3205956875 cites W2130657993 @default.
- W3205956875 cites W2145486738 @default.
- W3205956875 cites W2155492217 @default.
- W3205956875 cites W2171919974 @default.
- W3205956875 cites W2424948145 @default.
- W3205956875 cites W2491645136 @default.
- W3205956875 cites W2608361503 @default.
- W3205956875 cites W2739262366 @default.
- W3205956875 cites W2767041803 @default.
- W3205956875 cites W2790740078 @default.
- W3205956875 cites W2792396026 @default.
- W3205956875 cites W2897293647 @default.
- W3205956875 cites W2906428833 @default.
- W3205956875 cites W2907186969 @default.
- W3205956875 cites W2938010296 @default.
- W3205956875 cites W2940815861 @default.
- W3205956875 cites W2980190426 @default.
- W3205956875 cites W2983332596 @default.
- W3205956875 cites W2983648972 @default.
- W3205956875 cites W2983742483 @default.
- W3205956875 cites W3003999016 @default.
- W3205956875 cites W3011686543 @default.
- W3205956875 cites W3033656574 @default.
- W3205956875 cites W3087447407 @default.
- W3205956875 cites W3126851117 @default.
- W3205956875 cites W3131528222 @default.
- W3205956875 cites W3134457893 @default.
- W3205956875 cites W3144393714 @default.
- W3205956875 cites W4327849125 @default.
- W3205956875 doi "https://doi.org/10.1111/tri.14133" @default.
- W3205956875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34632641" @default.
- W3205956875 hasPublicationYear "2021" @default.
- W3205956875 type Work @default.
- W3205956875 sameAs 3205956875 @default.
- W3205956875 citedByCount "5" @default.
- W3205956875 countsByYear W32059568752022 @default.
- W3205956875 countsByYear W32059568752023 @default.
- W3205956875 crossrefType "journal-article" @default.
- W3205956875 hasAuthorship W3205956875A5001930460 @default.
- W3205956875 hasAuthorship W3205956875A5014833790 @default.
- W3205956875 hasAuthorship W3205956875A5033180014 @default.
- W3205956875 hasAuthorship W3205956875A5033543022 @default.
- W3205956875 hasAuthorship W3205956875A5036696731 @default.
- W3205956875 hasAuthorship W3205956875A5061379662 @default.
- W3205956875 hasAuthorship W3205956875A5076415613 @default.
- W3205956875 hasAuthorship W3205956875A5086943690 @default.
- W3205956875 hasAuthorship W3205956875A5090852510 @default.
- W3205956875 hasAuthorship W3205956875A5091131201 @default.
- W3205956875 hasConcept C104317684 @default.
- W3205956875 hasConcept C121587040 @default.
- W3205956875 hasConcept C126322002 @default.
- W3205956875 hasConcept C127716648 @default.
- W3205956875 hasConcept C136013683 @default.
- W3205956875 hasConcept C150194340 @default.
- W3205956875 hasConcept C2776908417 @default.
- W3205956875 hasConcept C2778215940 @default.
- W3205956875 hasConcept C2779134260 @default.
- W3205956875 hasConcept C2780091579 @default.
- W3205956875 hasConcept C2780303639 @default.
- W3205956875 hasConcept C2780368995 @default.
- W3205956875 hasConcept C2780673598 @default.
- W3205956875 hasConcept C2909652001 @default.
- W3205956875 hasConcept C2911091166 @default.
- W3205956875 hasConcept C54355233 @default.
- W3205956875 hasConcept C71924100 @default.
- W3205956875 hasConcept C80227256 @default.
- W3205956875 hasConcept C86803240 @default.
- W3205956875 hasConceptScore W3205956875C104317684 @default.
- W3205956875 hasConceptScore W3205956875C121587040 @default.
- W3205956875 hasConceptScore W3205956875C126322002 @default.
- W3205956875 hasConceptScore W3205956875C127716648 @default.
- W3205956875 hasConceptScore W3205956875C136013683 @default.
- W3205956875 hasConceptScore W3205956875C150194340 @default.
- W3205956875 hasConceptScore W3205956875C2776908417 @default.