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- W3205964128 abstract "Sphingolipids are bioactive lipids involved in the regulation of cell survival, proliferation, and the inflammatory response. The SphK/S1P/S1PR pathway (S1P pathway) is a driver of many anti-apoptotic and proliferative processes. Pro-survival sphingolipid sphingosine-1-phosphate (S1P) initiates its signaling cascade by interacting with various sphingosine-1-phosphate receptors (S1PR) through which it is able to exert its pro-survival or inflammatory effects. Whereas sphingolipids, including ceramides and sphingosines are pro-apoptotic. The pro-apoptotic lipid, ceramide, can be produced de novo by ceramide synthases and converted to sphingosine by way of ceramidases. The balance of these antagonistic lipids and how this balance manifests is the essence of the sphingolipid rheostat. Recent studies on SARS-CoV-2 have implicated the S1P pathway in the pathogenesis of novel coronavirus disease COVID-19-related lung damage. Accumulating evidence indicates that an aberrant inflammatory process, known as cytokine storm causes lung injury in COVID-19, and studies have shown that the S1P pathway is involved in signaling this hyperinflammatory response. Beyond the influence of this pathway on cytokine storm, over the last decade the S1P pathway has been investigated for its role in a wide array of lung pathologies, including pulmonary fibrosis, pulmonary arterial hypertension (PAH), and lung cancer. Various studies have used S1P pathway modulators in models of lung disease; many of these efforts have yielded results that point to the potential efficacy of targeting this pathway for future treatment options. Additionally, they have emphasized S1P pathway's significant role in inflammation, fibrosis, and a number of other endothelial and epithelial changes that contribute to lung damage. This review summarizes the S1P pathway's involvement in COVID-19 and chronic lung diseases and discusses the potential for targeting S1P pathway as a therapeutic option for these diseases." @default.
- W3205964128 created "2021-10-25" @default.
- W3205964128 creator A5005357486 @default.
- W3205964128 creator A5031370893 @default.
- W3205964128 creator A5057499082 @default.
- W3205964128 date "2021-10-08" @default.
- W3205964128 modified "2023-10-18" @default.
- W3205964128 title "Sphingolipids in Lung Pathology in the Coronavirus Disease Era: A Review of Sphingolipid Involvement in the Pathogenesis of Lung Damage" @default.
- W3205964128 cites W1506197730 @default.
- W3205964128 cites W1898460539 @default.
- W3205964128 cites W1900480423 @default.
- W3205964128 cites W1966452335 @default.
- W3205964128 cites W1967780469 @default.
- W3205964128 cites W1975061118 @default.
- W3205964128 cites W1975246259 @default.
- W3205964128 cites W1993449698 @default.
- W3205964128 cites W1993831163 @default.
- W3205964128 cites W1996605319 @default.
- W3205964128 cites W2011345944 @default.
- W3205964128 cites W2013331682 @default.
- W3205964128 cites W2014923090 @default.
- W3205964128 cites W2015092935 @default.
- W3205964128 cites W2020811083 @default.
- W3205964128 cites W2021663819 @default.
- W3205964128 cites W2033719765 @default.
- W3205964128 cites W2037730374 @default.
- W3205964128 cites W2038140733 @default.
- W3205964128 cites W2038237125 @default.
- W3205964128 cites W2047113737 @default.
- W3205964128 cites W2047607345 @default.
- W3205964128 cites W2062855802 @default.
- W3205964128 cites W2064224882 @default.
- W3205964128 cites W2069114926 @default.
- W3205964128 cites W2071733232 @default.
- W3205964128 cites W2104945338 @default.
- W3205964128 cites W2105333852 @default.
- W3205964128 cites W2106040829 @default.
- W3205964128 cites W2115065585 @default.
- W3205964128 cites W2116212271 @default.
- W3205964128 cites W2121559592 @default.
- W3205964128 cites W2122855165 @default.
- W3205964128 cites W2128629299 @default.
- W3205964128 cites W2128699525 @default.
- W3205964128 cites W2129689703 @default.
- W3205964128 cites W2133127604 @default.
- W3205964128 cites W2133189233 @default.
- W3205964128 cites W2140636998 @default.
- W3205964128 cites W2141809186 @default.
- W3205964128 cites W2143926802 @default.
- W3205964128 cites W2145076765 @default.
- W3205964128 cites W2149615364 @default.
- W3205964128 cites W2164934600 @default.
- W3205964128 cites W2197036948 @default.
- W3205964128 cites W2265704217 @default.
- W3205964128 cites W2282752390 @default.
- W3205964128 cites W2320649507 @default.
- W3205964128 cites W2340805753 @default.
- W3205964128 cites W2346478945 @default.
- W3205964128 cites W2466117104 @default.
- W3205964128 cites W2522895431 @default.
- W3205964128 cites W2525637603 @default.
- W3205964128 cites W2571554990 @default.
- W3205964128 cites W2596909218 @default.
- W3205964128 cites W2737765537 @default.
- W3205964128 cites W2769383666 @default.
- W3205964128 cites W2799664019 @default.
- W3205964128 cites W2804267567 @default.
- W3205964128 cites W2885671054 @default.
- W3205964128 cites W2895062844 @default.
- W3205964128 cites W2913213143 @default.
- W3205964128 cites W2943963057 @default.
- W3205964128 cites W2949033260 @default.
- W3205964128 cites W2953967368 @default.
- W3205964128 cites W2984859377 @default.
- W3205964128 cites W2995216880 @default.
- W3205964128 cites W3000224775 @default.
- W3205964128 cites W3003810671 @default.
- W3205964128 cites W3005655936 @default.
- W3205964128 cites W3008874180 @default.
- W3205964128 cites W3009912996 @default.
- W3205964128 cites W3011230498 @default.
- W3205964128 cites W3012006264 @default.
- W3205964128 cites W3016123694 @default.
- W3205964128 cites W3016124709 @default.
- W3205964128 cites W3017293186 @default.
- W3205964128 cites W3023419935 @default.
- W3205964128 cites W3026208825 @default.
- W3205964128 cites W3029291339 @default.
- W3205964128 cites W3029626770 @default.
- W3205964128 cites W3030929748 @default.
- W3205964128 cites W3033797727 @default.
- W3205964128 cites W3034226003 @default.
- W3205964128 cites W3037185429 @default.
- W3205964128 cites W3046117332 @default.
- W3205964128 cites W3046256437 @default.
- W3205964128 cites W3088607521 @default.
- W3205964128 cites W3089784499 @default.
- W3205964128 cites W3092254281 @default.
- W3205964128 cites W3092490718 @default.
- W3205964128 cites W3093686187 @default.