Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206001569> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W3206001569 endingPage "e37055" @default.
- W3206001569 startingPage "e37055" @default.
- W3206001569 abstract "Breast cancer appears as the main gynecological cancer and presents high morbidity and mortality. Because most diagnoses are made belatedly, it is necessary to seek therapeutic options that aim for advanced stages of the disease. This study aims to evaluate the antitumoral action of Stryphnodendron adstringens fruit extracts on 4T1 murine mammary carcinoma cell culture. The inhibitory potential of S. adstringens fruit extract on the metalloproteinases (MMPs) 2 and 9 was evaluated through zymography. From these results, MTT assays were performed to evaluate the extracts’ effects on the murine mammary carcinoma 4T1 line cell viability. From the crude extract, the following extracts were obtained: hydroalcoholic (SAFCEA), hexane (SAFCEB), chloroform (SAFCEC), and ethyl acetate (SAFCED). Lastly, the migration of the cells treated with extracts SAFCEA and SAFCED was verified. The hydroalcoholic extract (SAFCEA) was the most efficient in inhibiting gelatinases. During the phytochemical study, it was noted that alkaloids were present in all partitions. The 50 % growth inhibition (IC50) concentrations found were: 40.1 μg/mL (SAFCEA) and 70.14 μg/mL (SAFCED). After the cellular cytotoxicity assay, cell morphology was altered by treatment with the selected partitions (SAFCEA and SAFCED), obtaining morphology consistent with apoptosis. The results demonstrate that S. adstringens extracts exhibit the inhibitory activity of MMP-2 and MMP-9 as well as cytotoxicity toward 4T1 tumor cells. These findings indicate that follow-up studies of the partitions from S. adstringens may lead to the development of novel chemotherapeutics for oncological treatments." @default.
- W3206001569 created "2021-10-25" @default.
- W3206001569 creator A5013740487 @default.
- W3206001569 creator A5026986507 @default.
- W3206001569 creator A5055329166 @default.
- W3206001569 creator A5062160983 @default.
- W3206001569 creator A5079331419 @default.
- W3206001569 creator A5086878011 @default.
- W3206001569 creator A5087396682 @default.
- W3206001569 creator A5091446288 @default.
- W3206001569 date "2021-10-13" @default.
- W3206001569 modified "2023-10-12" @default.
- W3206001569 title "Effects of Stryphnodendron adstringens extracts on murine 4T1 tumor line" @default.
- W3206001569 doi "https://doi.org/10.14393/bj-v37n0a2021-50347" @default.
- W3206001569 hasPublicationYear "2021" @default.
- W3206001569 type Work @default.
- W3206001569 sameAs 3206001569 @default.
- W3206001569 citedByCount "0" @default.
- W3206001569 crossrefType "journal-article" @default.
- W3206001569 hasAuthorship W3206001569A5013740487 @default.
- W3206001569 hasAuthorship W3206001569A5026986507 @default.
- W3206001569 hasAuthorship W3206001569A5055329166 @default.
- W3206001569 hasAuthorship W3206001569A5062160983 @default.
- W3206001569 hasAuthorship W3206001569A5079331419 @default.
- W3206001569 hasAuthorship W3206001569A5086878011 @default.
- W3206001569 hasAuthorship W3206001569A5087396682 @default.
- W3206001569 hasAuthorship W3206001569A5091446288 @default.
- W3206001569 hasBestOaLocation W32060015691 @default.
- W3206001569 hasConcept C109316439 @default.
- W3206001569 hasConcept C109523444 @default.
- W3206001569 hasConcept C177430391 @default.
- W3206001569 hasConcept C185592680 @default.
- W3206001569 hasConcept C190283241 @default.
- W3206001569 hasConcept C195475562 @default.
- W3206001569 hasConcept C202751555 @default.
- W3206001569 hasConcept C2777752497 @default.
- W3206001569 hasConcept C2780783641 @default.
- W3206001569 hasConcept C53227056 @default.
- W3206001569 hasConcept C54355233 @default.
- W3206001569 hasConcept C55493867 @default.
- W3206001569 hasConcept C556039675 @default.
- W3206001569 hasConcept C71924100 @default.
- W3206001569 hasConcept C81885089 @default.
- W3206001569 hasConcept C86803240 @default.
- W3206001569 hasConcept C98274493 @default.
- W3206001569 hasConceptScore W3206001569C109316439 @default.
- W3206001569 hasConceptScore W3206001569C109523444 @default.
- W3206001569 hasConceptScore W3206001569C177430391 @default.
- W3206001569 hasConceptScore W3206001569C185592680 @default.
- W3206001569 hasConceptScore W3206001569C190283241 @default.
- W3206001569 hasConceptScore W3206001569C195475562 @default.
- W3206001569 hasConceptScore W3206001569C202751555 @default.
- W3206001569 hasConceptScore W3206001569C2777752497 @default.
- W3206001569 hasConceptScore W3206001569C2780783641 @default.
- W3206001569 hasConceptScore W3206001569C53227056 @default.
- W3206001569 hasConceptScore W3206001569C54355233 @default.
- W3206001569 hasConceptScore W3206001569C55493867 @default.
- W3206001569 hasConceptScore W3206001569C556039675 @default.
- W3206001569 hasConceptScore W3206001569C71924100 @default.
- W3206001569 hasConceptScore W3206001569C81885089 @default.
- W3206001569 hasConceptScore W3206001569C86803240 @default.
- W3206001569 hasConceptScore W3206001569C98274493 @default.
- W3206001569 hasLocation W32060015691 @default.
- W3206001569 hasLocation W32060015692 @default.
- W3206001569 hasLocation W32060015693 @default.
- W3206001569 hasOpenAccess W3206001569 @default.
- W3206001569 hasPrimaryLocation W32060015691 @default.
- W3206001569 hasRelatedWork W1972933415 @default.
- W3206001569 hasRelatedWork W1980902990 @default.
- W3206001569 hasRelatedWork W2028067028 @default.
- W3206001569 hasRelatedWork W2042303973 @default.
- W3206001569 hasRelatedWork W2087087143 @default.
- W3206001569 hasRelatedWork W2117980967 @default.
- W3206001569 hasRelatedWork W2383320628 @default.
- W3206001569 hasRelatedWork W2421372801 @default.
- W3206001569 hasRelatedWork W2680992019 @default.
- W3206001569 hasRelatedWork W2782857268 @default.
- W3206001569 hasVolume "37" @default.
- W3206001569 isParatext "false" @default.
- W3206001569 isRetracted "false" @default.
- W3206001569 magId "3206001569" @default.
- W3206001569 workType "article" @default.