FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206021083> ?p ?o ?g. }

• W3206021083 endingPage "2803" @default.
• W3206021083 startingPage "2803" @default.
• W3206021083 abstract "3-Poly-phosphoinositides (PIP3) regulate cell survival, division, and migration. Both PI3-kinase (phosphoinositide-3-kinase) and PTEN (phosphatase and tensin-homolog in chromosome 10) control PIP3 levels, but the mechanisms connecting PI3-kinase and PTEN are unknown. Using non-transformed cells, the activation kinetics of PTEN and of the PIP3-effector AKT were examined after the addition of growth factors. Both epidermal growth factor and serum induced the early activation of AKT and the simultaneous inactivation of PTEN (at ~5 min). This PIP3/AKT peak was followed by a general reduction in AKT activity coincident with the recovery of PTEN phosphatase activity (at ~10-15 min). Subsequent AKT peaks and troughs followed. The fluctuation in AKT activity was linked to that of PTEN; PTEN reconstitution in PTEN-null cells restored AKT fluctuations, while PTEN depletion in control cells abrogated them. The analysis of PTEN activity fluctuations after the addition of growth factors showed its inactivation at ~5 min to be simultaneous with its transient ubiquitination, which was regulated by the ubiquitin E3 ligase cCBL (casitas B-lineage lymphoma proto-oncogene). Protein-protein interaction analysis revealed cCBL to be brought into the proximity of PTEN in a PI3-kinase-dependent manner. These results reveal a mechanism for PI3-kinase/PTEN crosstalk and suggest that cCBL could be new target in strategies designed to modulate PTEN activity in cancer." @default.
• W3206021083 created "2021-10-25" @default.
• W3206021083 creator A5002459376 @default.
• W3206021083 creator A5013868026 @default.
• W3206021083 creator A5023273311 @default.
• W3206021083 creator A5042997422 @default.
• W3206021083 creator A5057143508 @default.
• W3206021083 creator A5077684513 @default.
• W3206021083 creator A5078088248 @default.
• W3206021083 date "2021-10-20" @default.
• W3206021083 modified "2023-10-17" @default.
• W3206021083 title "Fluctuations in AKT and PTEN Activity Are Linked by the E3 Ubiquitin Ligase cCBL" @default.
• W3206021083 cites W1652264402 @default.
• W3206021083 cites W1920844816 @default.
• W3206021083 cites W1988606601 @default.
• W3206021083 cites W1988769784 @default.
• W3206021083 cites W1991264372 @default.
• W3206021083 cites W1998038367 @default.
• W3206021083 cites W2015926136 @default.
• W3206021083 cites W2025378988 @default.
• W3206021083 cites W2033145757 @default.
• W3206021083 cites W2033667332 @default.
• W3206021083 cites W2038894919 @default.
• W3206021083 cites W2041895857 @default.
• W3206021083 cites W2049568871 @default.
• W3206021083 cites W2053949782 @default.
• W3206021083 cites W2055356876 @default.
• W3206021083 cites W2065652048 @default.
• W3206021083 cites W2066745745 @default.
• W3206021083 cites W2067413414 @default.
• W3206021083 cites W2067576594 @default.
• W3206021083 cites W2076194625 @default.
• W3206021083 cites W2094068658 @default.
• W3206021083 cites W2095659495 @default.
• W3206021083 cites W2095683698 @default.
• W3206021083 cites W2099658407 @default.
• W3206021083 cites W2100233587 @default.
• W3206021083 cites W2100486339 @default.
• W3206021083 cites W2100818075 @default.
• W3206021083 cites W2129546321 @default.
• W3206021083 cites W2134629247 @default.
• W3206021083 cites W2158499173 @default.
• W3206021083 cites W2159801541 @default.
• W3206021083 cites W2162338472 @default.
• W3206021083 cites W2168239981 @default.
• W3206021083 cites W2168286074 @default.
• W3206021083 cites W2522884107 @default.
• W3206021083 cites W2606513998 @default.
• W3206021083 cites W2907518492 @default.
• W3206021083 cites W2945658350 @default.
• W3206021083 cites W2950050166 @default.
• W3206021083 cites W2962828647 @default.
• W3206021083 cites W2987288669 @default.
• W3206021083 cites W2997993319 @default.
• W3206021083 cites W2999087022 @default.
• W3206021083 cites W2999182948 @default.
• W3206021083 cites W4238567307 @default.
• W3206021083 doi "https://doi.org/10.3390/cells10112803" @default.
• W3206021083 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8616390" @default.
• W3206021083 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34831026" @default.
• W3206021083 hasPublicationYear "2021" @default.
• W3206021083 type Work @default.
• W3206021083 sameAs 3206021083 @default.
• W3206021083 citedByCount "4" @default.
• W3206021083 countsByYear W32060210832022 @default.
• W3206021083 countsByYear W32060210832023 @default.
• W3206021083 crossrefType "journal-article" @default.
• W3206021083 hasAuthorship W3206021083A5002459376 @default.
• W3206021083 hasAuthorship W3206021083A5013868026 @default.
• W3206021083 hasAuthorship W3206021083A5023273311 @default.
• W3206021083 hasAuthorship W3206021083A5042997422 @default.
• W3206021083 hasAuthorship W3206021083A5057143508 @default.
• W3206021083 hasAuthorship W3206021083A5077684513 @default.
• W3206021083 hasAuthorship W3206021083A5078088248 @default.
• W3206021083 hasBestOaLocation W32060210831 @default.
• W3206021083 hasConcept C104317684 @default.
• W3206021083 hasConcept C11960822 @default.
• W3206021083 hasConcept C134459356 @default.
• W3206021083 hasConcept C178666793 @default.
• W3206021083 hasConcept C185592680 @default.
• W3206021083 hasConcept C25602115 @default.
• W3206021083 hasConcept C2777609662 @default.
• W3206021083 hasConcept C2779549131 @default.
• W3206021083 hasConcept C2781322055 @default.
• W3206021083 hasConcept C502942594 @default.
• W3206021083 hasConcept C55493867 @default.
• W3206021083 hasConcept C62478195 @default.
• W3206021083 hasConcept C75217442 @default.
• W3206021083 hasConcept C86554907 @default.
• W3206021083 hasConcept C86803240 @default.
• W3206021083 hasConcept C95444343 @default.
• W3206021083 hasConceptScore W3206021083C104317684 @default.
• W3206021083 hasConceptScore W3206021083C11960822 @default.
• W3206021083 hasConceptScore W3206021083C134459356 @default.
• W3206021083 hasConceptScore W3206021083C178666793 @default.
• W3206021083 hasConceptScore W3206021083C185592680 @default.
• W3206021083 hasConceptScore W3206021083C25602115 @default.
• W3206021083 hasConceptScore W3206021083C2777609662 @default.

• next