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- W3206023504 abstract "Neurological and neuronal disorders are associated with structural, biochemical, or electrical abnormalities in the nervous system. Many neurological diseases have not yet been discovered. Interventions used for the treatment of these disorders include avoidance measures, lifestyle changes, physiotherapy, neurorehabilitation, pain management, medication, and surgery. In the sodium channelopathies, alterations in the structure, expression, and function of voltage-gated sodium channels (VGSCs) are considered as the causes of neurological and neuronal diseases. Online databases, including Scopus, Science Direct, Google Scholar, and PubMed were assessed for studies published between 1977 and 2020 using the keywords of review, sodium channels blocker, neurological diseases, and neuronal diseases. VGSCs consist of one α subunit and two β subunits. These subunits are known to regulate the gating kinetics, functional characteristics, and localization of the ion channel. These channels are involved in cell migration, cellular connections, neuronal pathfinding, and neurite outgrowth. Through the VGSC, the action potential is triggered and propagated in the neurons. Action potentials are physiological functions and passage of impermeable ions. The electrophysiological properties of these channels and their relationship with neurological and neuronal disorders have been identified. Subunit mutations are involved in the development of diseases, such as epilepsy, multiple sclerosis, autism, and Alzheimer's disease. Accordingly, we conducted a review of the link between VGSCs and neurological and neuronal diseases. Also, novel therapeutic targets were introduced for future drug discoveries." @default.
- W3206023504 created "2021-10-25" @default.
- W3206023504 creator A5012858753 @default.
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- W3206023504 creator A5054883139 @default.
- W3206023504 date "2021-11-07" @default.
- W3206023504 modified "2023-09-24" @default.
- W3206023504 title "The effect of sodium channels on neurological/neuronal disorders: A systematic review" @default.
- W3206023504 cites W1070329031 @default.
- W3206023504 cites W1570677845 @default.
- W3206023504 cites W1578004315 @default.
- W3206023504 cites W1578423490 @default.
- W3206023504 cites W1593157837 @default.
- W3206023504 cites W1606137504 @default.
- W3206023504 cites W1607206274 @default.
- W3206023504 cites W1607372012 @default.
- W3206023504 cites W1637989849 @default.
- W3206023504 cites W1798842141 @default.
- W3206023504 cites W1824114135 @default.
- W3206023504 cites W1828576284 @default.
- W3206023504 cites W1861858988 @default.
- W3206023504 cites W1964533239 @default.
- W3206023504 cites W1965887065 @default.
- W3206023504 cites W1966330282 @default.
- W3206023504 cites W1967464880 @default.
- W3206023504 cites W1968495411 @default.
- W3206023504 cites W1970789949 @default.
- W3206023504 cites W1970910654 @default.
- W3206023504 cites W1974841170 @default.
- W3206023504 cites W1976325983 @default.
- W3206023504 cites W1976470591 @default.
- W3206023504 cites W1976769820 @default.
- W3206023504 cites W1976810263 @default.
- W3206023504 cites W1977035226 @default.
- W3206023504 cites W1977477115 @default.
- W3206023504 cites W1978839145 @default.
- W3206023504 cites W1979612107 @default.
- W3206023504 cites W1980176764 @default.
- W3206023504 cites W1980304382 @default.
- W3206023504 cites W1983568884 @default.
- W3206023504 cites W1983850763 @default.
- W3206023504 cites W1985952197 @default.
- W3206023504 cites W1988681996 @default.
- W3206023504 cites W1988932597 @default.
- W3206023504 cites W1991138408 @default.
- W3206023504 cites W1991601479 @default.
- W3206023504 cites W1992012908 @default.
- W3206023504 cites W1992118391 @default.
- W3206023504 cites W1995039815 @default.
- W3206023504 cites W1995100344 @default.
- W3206023504 cites W1997301424 @default.
- W3206023504 cites W2002812952 @default.
- W3206023504 cites W2006288144 @default.
- W3206023504 cites W2009154553 @default.
- W3206023504 cites W2009742334 @default.
- W3206023504 cites W2010687658 @default.
- W3206023504 cites W2011385800 @default.
- W3206023504 cites W2011394987 @default.
- W3206023504 cites W2011747578 @default.
- W3206023504 cites W2011973432 @default.
- W3206023504 cites W2016449989 @default.
- W3206023504 cites W2021051417 @default.
- W3206023504 cites W2022045362 @default.
- W3206023504 cites W2024205788 @default.
- W3206023504 cites W2025260963 @default.
- W3206023504 cites W2026551310 @default.
- W3206023504 cites W2026802237 @default.
- W3206023504 cites W2028922575 @default.
- W3206023504 cites W2030119843 @default.
- W3206023504 cites W2031827634 @default.
- W3206023504 cites W2034102853 @default.
- W3206023504 cites W2034208007 @default.
- W3206023504 cites W2037355835 @default.
- W3206023504 cites W2046998604 @default.
- W3206023504 cites W2047347093 @default.
- W3206023504 cites W2048073009 @default.
- W3206023504 cites W2048685634 @default.
- W3206023504 cites W2049960044 @default.
- W3206023504 cites W2050659319 @default.
- W3206023504 cites W2050910050 @default.
- W3206023504 cites W2051095850 @default.
- W3206023504 cites W2052530454 @default.
- W3206023504 cites W2057440436 @default.
- W3206023504 cites W2058313056 @default.
- W3206023504 cites W2064025488 @default.
- W3206023504 cites W2064609029 @default.
- W3206023504 cites W2065214055 @default.
- W3206023504 cites W2065857917 @default.
- W3206023504 cites W2066214818 @default.
- W3206023504 cites W2068648104 @default.
- W3206023504 cites W2070857423 @default.
- W3206023504 cites W2072168022 @default.
- W3206023504 cites W2074099509 @default.
- W3206023504 cites W2079044818 @default.
- W3206023504 cites W2081388499 @default.
- W3206023504 cites W2081700981 @default.