Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206024634> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W3206024634 endingPage "119917" @default.
- W3206024634 startingPage "119917" @default.
- W3206024634 abstract "Cerebral amyloid angiopathy (CAA) is characterized by microangiopathy with increased susceptibility to hemorrhages. Some patients may develop an inflammatory form presenting with focal deficits, seizures and alterations of vigilance (CAA-related inflammation episodes-CAA-ri). To report on clinical and biological findings of a case of CAA-ri after COVID-19 Tozinameran vaccination. CSF exam and brain MRI were done. A 77 year-old male with recent brain hemorrhage in an established probable CAA presented to ER for fever and confessional state 14 days after Tozinameran first dose vaccination. Neurological examination found the patient alert, confused, with hypertonia and action tremor but no meningeal signs. Blood investigations revealed inflammation without microbiological findings. CSF study showed increased proteins, lymphocytic pleocytosis (122 cells/uL) and mirror pattern. CSF Beta42 amyloid level was reduced (158 ng/L), t-Tau level increased. ApoE haplotype resulted E3/E4. The patient had refractory convulsive status epilepticus. MRI confirmed known subacute occipital hemorrhage, multiple microbleeds and occipito-parietal and frontal white matter vasogenic oedema. After a diagnosis of probable CAA-ri, high dose steroid therapy was started followed by clinical improvement and CSF normalization. Anti SARS CoV 2 antibodies were found in serum and CSF before and after steroid therapy. Following Tozinameran vaccine, a patient with probable CAA developed a systemic inflammation with neuroimaging signs of CAA-ri and persisting positive CSF anti-spike protein antibodies. We suggest that systemic inflammation evoked by anti-COVID vaccination may have induced CAA-ri in a patient with sub acute intracerebral hemorrhage. Cross-reaction of anti-spike antibodies with endothelial antigens in amyloid microangiopathy should be further studied." @default.
- W3206024634 created "2021-10-25" @default.
- W3206024634 creator A5018709543 @default.
- W3206024634 creator A5022097093 @default.
- W3206024634 creator A5022757199 @default.
- W3206024634 creator A5026572860 @default.
- W3206024634 creator A5034872657 @default.
- W3206024634 creator A5037203285 @default.
- W3206024634 creator A5046059107 @default.
- W3206024634 creator A5052809448 @default.
- W3206024634 date "2021-10-01" @default.
- W3206024634 modified "2023-09-27" @default.
- W3206024634 title "Cerebral amyloid angiopathy – Related inflammation after COVID-19 vaccination: Case or causality?" @default.
- W3206024634 doi "https://doi.org/10.1016/j.jns.2021.119917" @default.
- W3206024634 hasPublicationYear "2021" @default.
- W3206024634 type Work @default.
- W3206024634 sameAs 3206024634 @default.
- W3206024634 citedByCount "2" @default.
- W3206024634 countsByYear W32060246342021 @default.
- W3206024634 countsByYear W32060246342022 @default.
- W3206024634 crossrefType "journal-article" @default.
- W3206024634 hasAuthorship W3206024634A5018709543 @default.
- W3206024634 hasAuthorship W3206024634A5022097093 @default.
- W3206024634 hasAuthorship W3206024634A5022757199 @default.
- W3206024634 hasAuthorship W3206024634A5026572860 @default.
- W3206024634 hasAuthorship W3206024634A5034872657 @default.
- W3206024634 hasAuthorship W3206024634A5037203285 @default.
- W3206024634 hasAuthorship W3206024634A5046059107 @default.
- W3206024634 hasAuthorship W3206024634A5052809448 @default.
- W3206024634 hasBestOaLocation W32060246341 @default.
- W3206024634 hasConcept C118552586 @default.
- W3206024634 hasConcept C126322002 @default.
- W3206024634 hasConcept C142724271 @default.
- W3206024634 hasConcept C203014093 @default.
- W3206024634 hasConcept C2522874641 @default.
- W3206024634 hasConcept C2776914184 @default.
- W3206024634 hasConcept C2777094939 @default.
- W3206024634 hasConcept C2777341932 @default.
- W3206024634 hasConcept C2777483564 @default.
- W3206024634 hasConcept C2777736543 @default.
- W3206024634 hasConcept C2777790613 @default.
- W3206024634 hasConcept C2778186239 @default.
- W3206024634 hasConcept C2779134260 @default.
- W3206024634 hasConcept C2779483572 @default.
- W3206024634 hasConcept C2779651940 @default.
- W3206024634 hasConcept C2780636500 @default.
- W3206024634 hasConcept C71924100 @default.
- W3206024634 hasConcept C83455156 @default.
- W3206024634 hasConceptScore W3206024634C118552586 @default.
- W3206024634 hasConceptScore W3206024634C126322002 @default.
- W3206024634 hasConceptScore W3206024634C142724271 @default.
- W3206024634 hasConceptScore W3206024634C203014093 @default.
- W3206024634 hasConceptScore W3206024634C2522874641 @default.
- W3206024634 hasConceptScore W3206024634C2776914184 @default.
- W3206024634 hasConceptScore W3206024634C2777094939 @default.
- W3206024634 hasConceptScore W3206024634C2777341932 @default.
- W3206024634 hasConceptScore W3206024634C2777483564 @default.
- W3206024634 hasConceptScore W3206024634C2777736543 @default.
- W3206024634 hasConceptScore W3206024634C2777790613 @default.
- W3206024634 hasConceptScore W3206024634C2778186239 @default.
- W3206024634 hasConceptScore W3206024634C2779134260 @default.
- W3206024634 hasConceptScore W3206024634C2779483572 @default.
- W3206024634 hasConceptScore W3206024634C2779651940 @default.
- W3206024634 hasConceptScore W3206024634C2780636500 @default.
- W3206024634 hasConceptScore W3206024634C71924100 @default.
- W3206024634 hasConceptScore W3206024634C83455156 @default.
- W3206024634 hasLocation W32060246341 @default.
- W3206024634 hasLocation W32060246342 @default.
- W3206024634 hasLocation W32060246343 @default.
- W3206024634 hasOpenAccess W3206024634 @default.
- W3206024634 hasPrimaryLocation W32060246341 @default.
- W3206024634 hasRelatedWork W1986691751 @default.
- W3206024634 hasRelatedWork W1996191991 @default.
- W3206024634 hasRelatedWork W2045413771 @default.
- W3206024634 hasRelatedWork W2052116489 @default.
- W3206024634 hasRelatedWork W2075251288 @default.
- W3206024634 hasRelatedWork W2083241494 @default.
- W3206024634 hasRelatedWork W2094899106 @default.
- W3206024634 hasRelatedWork W2113499944 @default.
- W3206024634 hasRelatedWork W2804856845 @default.
- W3206024634 hasRelatedWork W4386203917 @default.
- W3206024634 hasVolume "429" @default.
- W3206024634 isParatext "false" @default.
- W3206024634 isRetracted "false" @default.
- W3206024634 magId "3206024634" @default.
- W3206024634 workType "article" @default.