FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206041512> ?p ?o ?g. }

• W3206041512 abstract "Our previous studies demonstrated that cysteinyl leukotrienes receptor 1 (CysLT1R) knockout, pharmacological blockade, or hippocampus knockdown produced beneficial effects against Alzheimer's disease (AD); however, whether CysLT1R upregulation has deleterious effects on AD remains elusive.In this study, we investigated the changes in behaviors, hippocampal amyloidogenesis, and synapse plasticity after CysLT1R overexpression by microinfusion of the lentiviral vector, containing its coding sequence of mouse (LV-CysLT1R), into the bilateral dentate gyri (DG) of the hippocampus or CysLT1R activation by repeated systemic administration of its agonist YM-17690 (0.1 mg/kg, once a day, i.p., for 28 d).The behavior data showed that overexpression of CysLT1R in hippocampal DG or administration of YM-17690 deteriorated behavioral performance in Morris water maze (MWM), Y-maze tests, and novel object recognition (NOR) in young APP/PS1 mice. The further studies showed that these treatments significantly destroyed synaptic function, as evidenced by impaired hippocampal long-term potentiation (LTP), decreased spine density, low number of synapses, and decreased postsynaptic protein (PSD95), and promoted the generation of amyloid β (Aβ) through increased expression of BACE1 and PS1 in the hippocampus of young APP/PS1 mice.Together, our results indicate that CysLT1R upregulation accelerates memory impairment in young APP/PS1 mice, which is associated with promoting synaptic dysfunction and amyloidogenesis in the hippocampus." @default.
• W3206041512 created "2021-10-25" @default.
• W3206041512 creator A5033342390 @default.
• W3206041512 creator A5038420966 @default.
• W3206041512 creator A5048989648 @default.
• W3206041512 creator A5051364953 @default.
• W3206041512 creator A5070778587 @default.
• W3206041512 creator A5081155699 @default.
• W3206041512 creator A5081690911 @default.
• W3206041512 creator A5082416766 @default.
• W3206041512 creator A5085544366 @default.
• W3206041512 date "2021-01-01" @default.
• W3206041512 modified "2023-09-25" @default.
• W3206041512 title "Hippocampal CysLT1R overexpression or activation accelerates memory deficits, synaptic dysfunction, and amyloidogenesis in young APP/PS1 transgenic mice" @default.
• W3206041512 cites W1577444962 @default.
• W3206041512 cites W1888470382 @default.
• W3206041512 cites W1971210753 @default.
• W3206041512 cites W1981711965 @default.
• W3206041512 cites W1983899670 @default.
• W3206041512 cites W1993812537 @default.
• W3206041512 cites W2002734542 @default.
• W3206041512 cites W2007424284 @default.
• W3206041512 cites W2019825857 @default.
• W3206041512 cites W2029251290 @default.
• W3206041512 cites W2073175900 @default.
• W3206041512 cites W2079673521 @default.
• W3206041512 cites W2081213559 @default.
• W3206041512 cites W2083179636 @default.
• W3206041512 cites W2084805296 @default.
• W3206041512 cites W2099345876 @default.
• W3206041512 cites W2107538476 @default.
• W3206041512 cites W2111570868 @default.
• W3206041512 cites W2115111224 @default.
• W3206041512 cites W2329336071 @default.
• W3206041512 cites W2530369839 @default.
• W3206041512 cites W2547048338 @default.
• W3206041512 cites W2606066880 @default.
• W3206041512 cites W2612176871 @default.
• W3206041512 cites W267135921 @default.
• W3206041512 cites W2737103340 @default.
• W3206041512 cites W2763470121 @default.
• W3206041512 cites W2789935103 @default.
• W3206041512 cites W2809446062 @default.
• W3206041512 cites W2888239039 @default.
• W3206041512 cites W2888322964 @default.
• W3206041512 cites W2891635110 @default.
• W3206041512 cites W2933742326 @default.
• W3206041512 cites W2935334079 @default.
• W3206041512 cites W2941749695 @default.
• W3206041512 cites W2957553017 @default.
• W3206041512 cites W3013081121 @default.
• W3206041512 cites W3049388525 @default.
• W3206041512 cites W3106710707 @default.
• W3206041512 cites W3130991129 @default.
• W3206041512 doi "https://doi.org/10.21037/atm-21-4518" @default.
• W3206041512 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8576703" @default.
• W3206041512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34790737" @default.
• W3206041512 hasPublicationYear "2021" @default.
• W3206041512 type Work @default.
• W3206041512 sameAs 3206041512 @default.
• W3206041512 citedByCount "0" @default.
• W3206041512 crossrefType "journal-article" @default.
• W3206041512 hasAuthorship W3206041512A5033342390 @default.
• W3206041512 hasAuthorship W3206041512A5038420966 @default.
• W3206041512 hasAuthorship W3206041512A5048989648 @default.
• W3206041512 hasAuthorship W3206041512A5051364953 @default.
• W3206041512 hasAuthorship W3206041512A5070778587 @default.
• W3206041512 hasAuthorship W3206041512A5081155699 @default.
• W3206041512 hasAuthorship W3206041512A5081690911 @default.
• W3206041512 hasAuthorship W3206041512A5082416766 @default.
• W3206041512 hasAuthorship W3206041512A5085544366 @default.
• W3206041512 hasBestOaLocation W32060415121 @default.
• W3206041512 hasConcept C104317684 @default.
• W3206041512 hasConcept C126322002 @default.
• W3206041512 hasConcept C127561419 @default.
• W3206041512 hasConcept C148762608 @default.
• W3206041512 hasConcept C169760540 @default.
• W3206041512 hasConcept C170493617 @default.
• W3206041512 hasConcept C173396325 @default.
• W3206041512 hasConcept C174884520 @default.
• W3206041512 hasConcept C182704531 @default.
• W3206041512 hasConcept C185592680 @default.
• W3206041512 hasConcept C190283241 @default.
• W3206041512 hasConcept C25274449 @default.
• W3206041512 hasConcept C2778938600 @default.
• W3206041512 hasConcept C2779134260 @default.
• W3206041512 hasConcept C2781161787 @default.
• W3206041512 hasConcept C31705614 @default.
• W3206041512 hasConcept C44752575 @default.
• W3206041512 hasConcept C502032728 @default.
• W3206041512 hasConcept C55493867 @default.
• W3206041512 hasConcept C71924100 @default.
• W3206041512 hasConcept C86803240 @default.
• W3206041512 hasConcept C98229152 @default.
• W3206041512 hasConcept C98274493 @default.
• W3206041512 hasConceptScore W3206041512C104317684 @default.
• W3206041512 hasConceptScore W3206041512C126322002 @default.
• W3206041512 hasConceptScore W3206041512C127561419 @default.
• W3206041512 hasConceptScore W3206041512C148762608 @default.
• W3206041512 hasConceptScore W3206041512C169760540 @default.

• next