Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206044575> ?p ?o ?g. }
- W3206044575 abstract "Following prolonged exposure to hypoxic conditions, for example, due to ascent to high altitude, stroke, or traumatic brain injury, cerebral edema can develop. The exact nature and genesis of hypoxia-induced edema in healthy individuals remain unresolved. We examined the effects of prolonged, normobaric hypoxia, induced by 16 h of exposure to simulated high altitude, on healthy brains using proton, dynamic contrast enhanced, and sodium MRI. This dual approach allowed us to directly measure key factors in the development of hypoxia-induced brain edema: (1) Sodium signals as a surrogate of the distribution of electrolytes within the cerebral tissue and (2) Ktrans as a marker of blood-brain-barrier integrity. The measurements point toward an accumulation of sodium ions in extra- but not in intracellular space in combination with an intact endothelium. Both findings in combination are indicative of ionic extracellular edema, a subtype of cerebral edema that was only recently specified as an intermittent, yet distinct stage between cytotoxic and vasogenic edemas. In sum, here a combination of imaging techniques demonstrates the development of ionic edemas following prolonged normobaric hypoxia in agreement with cascadic models of edema formation." @default.
- W3206044575 created "2021-10-25" @default.
- W3206044575 creator A5019876508 @default.
- W3206044575 creator A5040010781 @default.
- W3206044575 creator A5040714848 @default.
- W3206044575 creator A5047869750 @default.
- W3206044575 creator A5059034476 @default.
- W3206044575 creator A5067653568 @default.
- W3206044575 creator A5070246576 @default.
- W3206044575 creator A5072066005 @default.
- W3206044575 creator A5079482117 @default.
- W3206044575 creator A5091550321 @default.
- W3206044575 date "2021-10-13" @default.
- W3206044575 modified "2023-09-26" @default.
- W3206044575 title "Exposure to 16 h of normobaric hypoxia induces ionic edema in the healthy brain" @default.
- W3206044575 cites W1028085286 @default.
- W3206044575 cites W1483165568 @default.
- W3206044575 cites W1529659572 @default.
- W3206044575 cites W1593248403 @default.
- W3206044575 cites W1827197946 @default.
- W3206044575 cites W1913915712 @default.
- W3206044575 cites W1979409390 @default.
- W3206044575 cites W1981856602 @default.
- W3206044575 cites W1993730892 @default.
- W3206044575 cites W1998189725 @default.
- W3206044575 cites W2006096283 @default.
- W3206044575 cites W2009745196 @default.
- W3206044575 cites W2012104505 @default.
- W3206044575 cites W2013176642 @default.
- W3206044575 cites W2014375144 @default.
- W3206044575 cites W2015921622 @default.
- W3206044575 cites W2021163309 @default.
- W3206044575 cites W2026616100 @default.
- W3206044575 cites W2029633395 @default.
- W3206044575 cites W2047435635 @default.
- W3206044575 cites W2054041825 @default.
- W3206044575 cites W2056840649 @default.
- W3206044575 cites W2061370709 @default.
- W3206044575 cites W2063140964 @default.
- W3206044575 cites W2068734467 @default.
- W3206044575 cites W2071564379 @default.
- W3206044575 cites W2071881327 @default.
- W3206044575 cites W2072500831 @default.
- W3206044575 cites W2092078486 @default.
- W3206044575 cites W2092649617 @default.
- W3206044575 cites W2095824142 @default.
- W3206044575 cites W2098788113 @default.
- W3206044575 cites W2105443363 @default.
- W3206044575 cites W2108610949 @default.
- W3206044575 cites W2111156333 @default.
- W3206044575 cites W2112573459 @default.
- W3206044575 cites W2125060405 @default.
- W3206044575 cites W2125749422 @default.
- W3206044575 cites W2134304229 @default.
- W3206044575 cites W2136312044 @default.
- W3206044575 cites W2136904423 @default.
- W3206044575 cites W2138394380 @default.
- W3206044575 cites W2139311549 @default.
- W3206044575 cites W2147816079 @default.
- W3206044575 cites W2148726987 @default.
- W3206044575 cites W2150148667 @default.
- W3206044575 cites W2165013650 @default.
- W3206044575 cites W2167234030 @default.
- W3206044575 cites W2173775886 @default.
- W3206044575 cites W2225902766 @default.
- W3206044575 cites W2291424342 @default.
- W3206044575 cites W2317312369 @default.
- W3206044575 cites W2485384080 @default.
- W3206044575 cites W2748435152 @default.
- W3206044575 cites W2795146597 @default.
- W3206044575 cites W2982629815 @default.
- W3206044575 doi "https://doi.org/10.1038/s41467-021-26116-y" @default.
- W3206044575 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8514510" @default.
- W3206044575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34645793" @default.
- W3206044575 hasPublicationYear "2021" @default.
- W3206044575 type Work @default.
- W3206044575 sameAs 3206044575 @default.
- W3206044575 citedByCount "6" @default.
- W3206044575 countsByYear W32060445752021 @default.
- W3206044575 countsByYear W32060445752022 @default.
- W3206044575 countsByYear W32060445752023 @default.
- W3206044575 crossrefType "journal-article" @default.
- W3206044575 hasAuthorship W3206044575A5019876508 @default.
- W3206044575 hasAuthorship W3206044575A5040010781 @default.
- W3206044575 hasAuthorship W3206044575A5040714848 @default.
- W3206044575 hasAuthorship W3206044575A5047869750 @default.
- W3206044575 hasAuthorship W3206044575A5059034476 @default.
- W3206044575 hasAuthorship W3206044575A5067653568 @default.
- W3206044575 hasAuthorship W3206044575A5070246576 @default.
- W3206044575 hasAuthorship W3206044575A5072066005 @default.
- W3206044575 hasAuthorship W3206044575A5079482117 @default.
- W3206044575 hasAuthorship W3206044575A5091550321 @default.
- W3206044575 hasBestOaLocation W32060445751 @default.
- W3206044575 hasConcept C126322002 @default.
- W3206044575 hasConcept C127413603 @default.
- W3206044575 hasConcept C142724271 @default.
- W3206044575 hasConcept C157767197 @default.
- W3206044575 hasConcept C178790620 @default.
- W3206044575 hasConcept C185592680 @default.
- W3206044575 hasConcept C2779493303 @default.