FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206046715> ?p ?o ?g. }

• W3206046715 abstract "Recent technological developments allow us to measure the status of dozens of proteins in individual cells. This opens the way to understand the heterogeneity of complex multi-signaling networks across cells and cell types, with important implications to understand and treat diseases such as cancer. These technologies are, however, limited to proteins for which antibodies are available and are fairly costly, making predictions of new markers and of existing markers under new conditions a valuable alternative. To assess our capacity to make such predictions and boost further methodological development, we organized the Single Cell Signaling in Breast Cancer DREAM challenge. We used a mass cytometry dataset, covering 36 markers in over 4,000 conditions totaling 80 million single cells across 67 breast cancer cell lines. Through four increasingly difficult subchallenges, the participants predicted missing markers, new conditions, and the time-course response of single cells to stimuli in the presence and absence of kinase inhibitors. The challenge results show that despite the stochastic nature of signal transduction in single cells, the signaling events are tightly controlled and machine learning methods can accurately predict new experimental data." @default.
• W3206046715 created "2021-10-25" @default.
• W3206046715 creator A5002480644 @default.
• W3206046715 creator A5003371668 @default.
• W3206046715 creator A5004341287 @default.
• W3206046715 creator A5005073322 @default.
• W3206046715 creator A5005499510 @default.
• W3206046715 creator A5008781342 @default.
• W3206046715 creator A5009235122 @default.
• W3206046715 creator A5009279289 @default.
• W3206046715 creator A5010246928 @default.
• W3206046715 creator A5010448208 @default.
• W3206046715 creator A5010642463 @default.
• W3206046715 creator A5010846438 @default.
• W3206046715 creator A5011219656 @default.
• W3206046715 creator A5011489319 @default.
• W3206046715 creator A5011504177 @default.
• W3206046715 creator A5012651955 @default.
• W3206046715 creator A5014529529 @default.
• W3206046715 creator A5015280014 @default.
• W3206046715 creator A5015461452 @default.
• W3206046715 creator A5015763587 @default.
• W3206046715 creator A5016305134 @default.
• W3206046715 creator A5018043372 @default.
• W3206046715 creator A5018257070 @default.
• W3206046715 creator A5021648197 @default.
• W3206046715 creator A5021802977 @default.
• W3206046715 creator A5021962955 @default.
• W3206046715 creator A5022246889 @default.
• W3206046715 creator A5023015562 @default.
• W3206046715 creator A5023132821 @default.
• W3206046715 creator A5023357394 @default.
• W3206046715 creator A5029353937 @default.
• W3206046715 creator A5030236051 @default.
• W3206046715 creator A5035877557 @default.
• W3206046715 creator A5036560561 @default.
• W3206046715 creator A5037342361 @default.
• W3206046715 creator A5038229891 @default.
• W3206046715 creator A5038346855 @default.
• W3206046715 creator A5038813656 @default.
• W3206046715 creator A5040152034 @default.
• W3206046715 creator A5041206246 @default.
• W3206046715 creator A5041208558 @default.
• W3206046715 creator A5041343853 @default.
• W3206046715 creator A5042780856 @default.
• W3206046715 creator A5044304242 @default.
• W3206046715 creator A5045143094 @default.
• W3206046715 creator A5045723319 @default.
• W3206046715 creator A5045895968 @default.
• W3206046715 creator A5048158238 @default.
• W3206046715 creator A5048185024 @default.
• W3206046715 creator A5049835218 @default.
• W3206046715 creator A5050239570 @default.
• W3206046715 creator A5052986544 @default.
• W3206046715 creator A5053385176 @default.
• W3206046715 creator A5054096262 @default.
• W3206046715 creator A5056068452 @default.
• W3206046715 creator A5056472221 @default.
• W3206046715 creator A5058447445 @default.
• W3206046715 creator A5058579386 @default.
• W3206046715 creator A5058611848 @default.
• W3206046715 creator A5059741782 @default.
• W3206046715 creator A5059885688 @default.
• W3206046715 creator A5060891602 @default.
• W3206046715 creator A5062627395 @default.
• W3206046715 creator A5062916900 @default.
• W3206046715 creator A5063605555 @default.
• W3206046715 creator A5063829272 @default.
• W3206046715 creator A5064170912 @default.
• W3206046715 creator A5064922397 @default.
• W3206046715 creator A5065141890 @default.
• W3206046715 creator A5066745646 @default.
• W3206046715 creator A5066992185 @default.
• W3206046715 creator A5068469075 @default.
• W3206046715 creator A5068809376 @default.
• W3206046715 creator A5070896210 @default.
• W3206046715 creator A5072280616 @default.
• W3206046715 creator A5074140420 @default.
• W3206046715 creator A5074576012 @default.
• W3206046715 creator A5075877965 @default.
• W3206046715 creator A5076992264 @default.
• W3206046715 creator A5077522146 @default.
• W3206046715 creator A5077598575 @default.
• W3206046715 creator A5078218565 @default.
• W3206046715 creator A5078264996 @default.
• W3206046715 creator A5079351898 @default.
• W3206046715 creator A5079995703 @default.
• W3206046715 creator A5080970538 @default.
• W3206046715 creator A5081003202 @default.
• W3206046715 creator A5081956801 @default.
• W3206046715 creator A5082142367 @default.
• W3206046715 creator A5082956060 @default.
• W3206046715 creator A5084343474 @default.
• W3206046715 creator A5085609944 @default.
• W3206046715 creator A5085611850 @default.
• W3206046715 creator A5087020441 @default.
• W3206046715 creator A5087975857 @default.
• W3206046715 date "2021-10-01" @default.
• W3206046715 modified "2023-10-18" @default.
• W3206046715 title "Cell‐to‐cell and type‐to‐type heterogeneity of signaling networks: insights from the crowd" @default.

• next