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- W3206055288 endingPage "103243" @default.
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- W3206055288 abstract "Prostaglandin E2 (PGE2) has recently been recognized to play a role in immune regulation and tissue regeneration. However, the short half-life of PGE2 limits its clinical application. Improving the delivery of PGE2 specifically to the target organ with a prolonged release method is highly desirable. Taking advantage of the adequate space and proximity of the renal parenchyma, renal subcapsular delivery allows minimally invasive and effective delivery to the entire kidney. Here, we report that by covalently cross-linking it to a collagen matrix, PGE2 exhibits an adequate long-term presence in the kidney with extensive intraparenchymal penetration through renal subcapsular delivery and significantly improves kidney function. Sox9 cell lineage tracing with intravital microscopy revealed that PGE2 could activate the endogenous renal progenitor Sox9+ cells through the Yap signaling pathway. Our results highlight the prospects of utilizing renal subcapsular-based drug delivery and facilitate new applications of PGE2-releasing matrices for regenerative therapy." @default.
- W3206055288 created "2021-10-25" @default.
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- W3206055288 date "2021-11-01" @default.
- W3206055288 modified "2023-10-14" @default.
- W3206055288 title "Renal subcapsular delivery of PGE2 promotes kidney repair by activating endogenous Sox9+ stem cells" @default.
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- W3206055288 doi "https://doi.org/10.1016/j.isci.2021.103243" @default.
- W3206055288 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8554536" @default.
- W3206055288 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34746706" @default.
- W3206055288 hasPublicationYear "2021" @default.
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