Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206055401> ?p ?o ?g. }
- W3206055401 abstract "The Spemann and Mangold Organizer (SMO) is of fundamental importance for dorsal ventral body axis formation during vertebrate embryogenesis. Maternal Huluwa (Hwa) has been identified as the dorsal determinant that is both necessary and sufficient for SMO formation. However, it remains unclear how Hwa is regulated. Here, we report that the E3 ubiquitin ligase zinc and ring finger 3 (ZNRF3) is essential for restricting the spatial activity of Hwa and therefore correct SMO formation in Xenopus laevis. ZNRF3 interacts with and ubiquitinates Hwa, thereby regulating its lysosomal trafficking and protein stability. Perturbation of ZNRF3 leads to the accumulation of Hwa and induction of an ectopic axis in embryos. Ectopic expression of ZNRF3 promotes Hwa degradation and dampens the axis-inducing activity of Hwa. Thus, our findings identify a substrate of ZNRF3, but also highlight the importance of the regulation of Hwa temporospatial activity in body axis formation in vertebrate embryos." @default.
- W3206055401 created "2021-10-25" @default.
- W3206055401 creator A5020891596 @default.
- W3206055401 creator A5021602083 @default.
- W3206055401 creator A5040096304 @default.
- W3206055401 creator A5045130424 @default.
- W3206055401 creator A5062341925 @default.
- W3206055401 creator A5066148242 @default.
- W3206055401 creator A5069612314 @default.
- W3206055401 date "2021-10-15" @default.
- W3206055401 modified "2023-10-09" @default.
- W3206055401 title "Lysosomal degradation of the maternal dorsal determinant Hwa safeguards dorsal body axis formation" @default.
- W3206055401 cites W1259045863 @default.
- W3206055401 cites W1533376056 @default.
- W3206055401 cites W1908541914 @default.
- W3206055401 cites W1971175769 @default.
- W3206055401 cites W1972666776 @default.
- W3206055401 cites W1977170331 @default.
- W3206055401 cites W2006170147 @default.
- W3206055401 cites W2007240253 @default.
- W3206055401 cites W2008221746 @default.
- W3206055401 cites W2016552656 @default.
- W3206055401 cites W2023918911 @default.
- W3206055401 cites W2024165183 @default.
- W3206055401 cites W2026112588 @default.
- W3206055401 cites W2029887943 @default.
- W3206055401 cites W2038073573 @default.
- W3206055401 cites W2071397057 @default.
- W3206055401 cites W2073239747 @default.
- W3206055401 cites W2074773822 @default.
- W3206055401 cites W2078058386 @default.
- W3206055401 cites W2078060536 @default.
- W3206055401 cites W2090636859 @default.
- W3206055401 cites W2090789702 @default.
- W3206055401 cites W2092630678 @default.
- W3206055401 cites W2105238625 @default.
- W3206055401 cites W2106236683 @default.
- W3206055401 cites W2108909298 @default.
- W3206055401 cites W2112032807 @default.
- W3206055401 cites W2112406299 @default.
- W3206055401 cites W2115686163 @default.
- W3206055401 cites W2123027097 @default.
- W3206055401 cites W2126750468 @default.
- W3206055401 cites W2126855072 @default.
- W3206055401 cites W2132842793 @default.
- W3206055401 cites W2139043462 @default.
- W3206055401 cites W2139589961 @default.
- W3206055401 cites W2139898476 @default.
- W3206055401 cites W2150068899 @default.
- W3206055401 cites W2183562483 @default.
- W3206055401 cites W2188347498 @default.
- W3206055401 cites W2352023541 @default.
- W3206055401 cites W2417500899 @default.
- W3206055401 cites W2520632143 @default.
- W3206055401 cites W2621361823 @default.
- W3206055401 cites W2800286806 @default.
- W3206055401 cites W2803820523 @default.
- W3206055401 cites W2887866682 @default.
- W3206055401 cites W2901083302 @default.
- W3206055401 cites W2998808285 @default.
- W3206055401 cites W3036318695 @default.
- W3206055401 cites W3048286720 @default.
- W3206055401 cites W3087660137 @default.
- W3206055401 cites W3089896411 @default.
- W3206055401 cites W3095635070 @default.
- W3206055401 cites W3140857766 @default.
- W3206055401 cites W3206055401 @default.
- W3206055401 doi "https://doi.org/10.15252/embr.202153185" @default.
- W3206055401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34652064" @default.
- W3206055401 hasPublicationYear "2021" @default.
- W3206055401 type Work @default.
- W3206055401 sameAs 3206055401 @default.
- W3206055401 citedByCount "3" @default.
- W3206055401 countsByYear W32060554012021 @default.
- W3206055401 countsByYear W32060554012022 @default.
- W3206055401 crossrefType "journal-article" @default.
- W3206055401 hasAuthorship W3206055401A5020891596 @default.
- W3206055401 hasAuthorship W3206055401A5021602083 @default.
- W3206055401 hasAuthorship W3206055401A5040096304 @default.
- W3206055401 hasAuthorship W3206055401A5045130424 @default.
- W3206055401 hasAuthorship W3206055401A5062341925 @default.
- W3206055401 hasAuthorship W3206055401A5066148242 @default.
- W3206055401 hasAuthorship W3206055401A5069612314 @default.
- W3206055401 hasBestOaLocation W32060554011 @default.
- W3206055401 hasConcept C104317684 @default.
- W3206055401 hasConcept C105702510 @default.
- W3206055401 hasConcept C134459356 @default.
- W3206055401 hasConcept C196843134 @default.
- W3206055401 hasConcept C25602115 @default.
- W3206055401 hasConcept C2778961482 @default.
- W3206055401 hasConcept C2779535977 @default.
- W3206055401 hasConcept C54355233 @default.
- W3206055401 hasConcept C86803240 @default.
- W3206055401 hasConcept C95444343 @default.
- W3206055401 hasConcept C97037327 @default.
- W3206055401 hasConceptScore W3206055401C104317684 @default.
- W3206055401 hasConceptScore W3206055401C105702510 @default.
- W3206055401 hasConceptScore W3206055401C134459356 @default.
- W3206055401 hasConceptScore W3206055401C196843134 @default.
- W3206055401 hasConceptScore W3206055401C25602115 @default.