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- W3206056722 abstract "Didymocarpus pedicellata (Family: Gesneriaceae), is an herbal drug traditionally used in renal disorders mainly as antiurolithiatic and do not have much data on this plant, is selected for study and hereby reviewed. This review is based on compilation of data from the various researchers on their research work and other data including anti-diabetic activity of Didymocarpus pedicellata and antioxidant activity in relation with the type 2 diabetes mellitus and its cardiovascular complications. By using various scientific studies, the evidence has been demonstrated as to the antidiabetic effect of the various extract of Didymocarpus pedicellata as well as its chemical constituents including various flavonoid like chalcones which are major bioactive constituents chiefly present in Didymocarpus pedicellata. The chalcones present in these plants have various therapeutic targets for the management of type 2 diabetes like PPARg, DPP-4, a-glucosidase, PTP1B, aldose reductase, and stimulate insulin secretion and tissue sensitivity. The Didymocarpus pedicellata has also been reported to exhibit antispasmolytic, antimalarial activity and nephroprotective activity. On the basis of given evidence, it may be concluded that Didymocarpus pedicellata could be the potential target for the treatment of type 2 diabetes mellitus and can reduce the cardiovascular complication associated with diabetes mellitus." @default.
- W3206056722 created "2021-10-25" @default.
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- W3206056722 date "2021-09-15" @default.
- W3206056722 modified "2023-09-29" @default.
- W3206056722 title "Didymocarpus Pedicellate: Bioactive Constituent, Their Molecular Target in Diabetes Mellitus" @default.
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- W3206056722 doi "https://doi.org/10.47583/ijpsrr.2021.v70i01.004" @default.
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