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- W3206072775 abstract "ABSTRACT Wound healing in the skin is a complex physiological process that is a product of a cell state transition from homeostasis to repair. Mechanical cues are increasingly being recognized as important regulators of cellular reprogramming, but the mechanism by which it is translated to changes in gene expression and ultimately cellular behavior remains largely a mystery. To probe the molecular underpinnings of this phenomenon further, we used the downregulation of caspase-8 as a biomarker of a cell entering the wound-healing program. We found that the wound-induced release of tension within the epidermis leads to the alteration of gene expression via the nuclear translocation of the DNA methyltransferase 3A (DNMT3a). This enzyme then methylates promoters of genes that are known to be downregulated in response to wound stimuli as well as potentially novel players in the repair program. Overall, these findings illuminate the convergence of mechanical and epigenetic signaling modules that are important regulators of the transcriptome landscape required to initiate the tissue repair process in the differentiated layers of the epidermis." @default.
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- W3206072775 date "2021-10-09" @default.
- W3206072775 modified "2023-10-15" @default.
- W3206072775 title "The initiation of the wound healing program is regulated by the convergence of mechanical and epigenetic cues" @default.
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- W3206072775 doi "https://doi.org/10.1101/2021.10.09.463764" @default.
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