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- W3206076172 abstract "Ginsenosides, the main components isolated from Panax ginseng, can play a therapeutic role by inducing tumor cell apoptosis and reducing proliferation, invasion, metastasis; by enhancing immune regulation; and by reversing tumor cell multidrug resistance. However, clinical applications have been limited because of ginsenosides' physical and chemical properties such as low solubility and poor stability, as well as their short half-life, easy elimination, degradation, and other pharmacokinetic properties in vivo. In recent years, developing a ginsenoside delivery system for bifunctional drugs or carriers has attracted much attention from researchers. To create a precise treatment strategy for cancer, a variety of nano delivery systems and preparation technologies based on ginsenosides have been conducted (e.g., polymer nanoparticles [NPs], liposomes, micelles, microemulsions, protein NPs, metals and inorganic NPs, biomimetic NPs). It is desirable to design a targeted delivery system to achieve antitumor efficacy that can not only cross various barriers but also can enhance immune regulation, eventually converting to a clinical application. Therefore, this review focused on the latest research about delivery systems encapsulated or modified with ginsenosides, and unification of medicines and excipients based on ginsenosides for improving drug bioavailability and targeting ability. In addition, challenges and new treatment methods were discussed to support the development of these new tumor therapeutic agents for use in clinical treatment." @default.
- W3206076172 created "2021-10-25" @default.
- W3206076172 creator A5007046565 @default.
- W3206076172 creator A5033020983 @default.
- W3206076172 creator A5038254958 @default.
- W3206076172 creator A5045839676 @default.
- W3206076172 creator A5050260933 @default.
- W3206076172 creator A5057578208 @default.
- W3206076172 creator A5072162524 @default.
- W3206076172 date "2021-10-15" @default.
- W3206076172 modified "2023-10-10" @default.
- W3206076172 title "Ginsenosides emerging as both bifunctional drugs and nanocarriers for enhanced antitumor therapies" @default.
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