Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206081625> ?p ?o ?g. }
- W3206081625 abstract "In this study, two strategies were used to functionalize cellulose nanowhiskers. Firstly, by grafting its surface with β-cyclodextrin (βCD) for developing drug-nanocarrier. Secondly, by conjugating short polymer segments to its surface for reinforcing Poly(Ɛ-Caprolactone) (PCL), in order to develop nanocomposites with promoted properties suitable for regenerative medicine. In addition, the production and recovery of biodegradable bioplastics poly(3-hydroxybutyrate) (P(3HB)) from agro-industrial residues of hemp hurd biomass was also examined. In the first part, a drug-nanocarrier system based on βCD-grafted bacterial cellulose nanowhisker (BCNC-g-βCD) was developed as a prolonged drug release nanocarrier. Antibiotic Ciprofloxacin (CIP) and anticancer drugs; Doxorubicin (DOX) and Paclitaxel (PTX) were conjugated to BCNC-g-βCD as model drugs to form the drug-nanocarrier (BCNC-g-βCD-drug). Compared with un-grafted BCNC, the developed drug-nanocarrier showed significant increase in drug payloads from 495 ±4 to 810 ±7 µg/mg along with radical improvement in the drug release profiles. Initial burst releases was reduced significantly and prolonged and sustained release for (74.5–90%) of drug payload over 4–5.5 days were observed. In addition, an improved drug release performances were pragmatic in acidic pH of 6.4 that mimicked extracellular tumor cells. In vitro drug release data pointed to zero-order kinetic model with estimated zero-order release constants (K0) of 0.68, 0.74, and 0.79 µg drug/h (at pH 6.4, 37°C) for BCNC-g-βCD-CIP, BCNC-g-βCD-DOX and BCNC-g-βCD-PTX nanosystems, respectively. In the second part, the functionalized bacterial cellulose nanowhisker (BCNW-g-βCD-PCL2000) was synthesized. Reinforcing PCL matrix with 4 wt% of the functionalized nanowhisker resulted in bionanocomposite with promoted bulk properties. Compared to neat PCL, the obtained bionanocomposite showed 115% and 51% improvements in tensile strength and Young’s modulus, respectively; 20% increase in hydrophilicity; 7% increase in degradation rate; and 6% decrease in crystallinity. Gas foaming/combined particulate leaching technique is used to develop highly porous strutures having porosity of 86-95% and interconnected macropores with mean pore diameters of 250-420 µm. Porous scaffolds showed compression moduli values of 5.3-9.1 MPa in the range of cancellous bones. In the third part a dual-function PCL scaffold was fabricated. The envisioned drug-laden scaffold would provide adequate structural and mechanical supports for the newly regenerated tissues and simultaneously serve as localized drug delivery system. In this context, reinforced PCL with 4 wt% of BCNW-g-βCD-PCL2000 and 25 wt% of doxorubicin anticancer drug resulted in drugladen bionanocomposite of combined promoted bulk properties. Improvements of 165% and 107% in tensile strength and Young’s modulus, respectively; 31% in hydrophilicity; 10% in degradation rate; and 8°C increases in thermal stability. The obtained drug-laden porous scaffolds showed compressive moduli in the range of 7.2-12.3 MPa. In vitro drug releases fit the first-order release mechanism and occurred in a diffusion-controlled and sustained manner 60 days without obvious burst releases. The scaffolds will ultimately minimize systemic toxicities of drugs, lessen the number of dosing, and diminish the need for removal procedure. The forth study described prospective trials for greener production and extraction of the biodegradable bioplastics poly(3-hydroxybutyrate) P(3HB) from agro-industrial residues of hemp hurd biomass. Results showed that maximum hydrolysis yield of 72.4% was achieved by alkali pretreatment with 2% NaOH at 135°C for 60 min along with two-step enzymatic hydrolysis and ultrasonication. Total hydrolysate sugar concentration of 53.0 g/L was obtained. Under optimum conditions, total P(3HB) production of 13.4 g/L was achieved within 80 h of fermentation. Ultrasonic-assisted sodium dodecyl sulfate (SDS) has showed effectiveness as economic recovery method. It recovered bioplastics directly from the broth cell concentrate with P(3HB) content of 92%. Number average molecular weights (Mn) of recovered bioplastics were in the range of 150–270 kDa with polydispersity index (Mw/Mn) of 2.1–2.4." @default.
- W3206081625 created "2021-10-25" @default.
- W3206081625 creator A5021019742 @default.
- W3206081625 date "2021-05-23" @default.
- W3206081625 modified "2023-09-27" @default.
- W3206081625 title "Different Approaches to the Synthesis and Applications of Biomedical and Pharmaceutical Smart Biomaterials" @default.
- W3206081625 cites W1217964832 @default.
- W3206081625 cites W1430607592 @default.
- W3206081625 cites W1543790510 @default.
- W3206081625 cites W15695342 @default.
- W3206081625 cites W1601255898 @default.
- W3206081625 cites W1731445934 @default.
- W3206081625 cites W1909186051 @default.
- W3206081625 cites W1912384057 @default.
- W3206081625 cites W1963666506 @default.
- W3206081625 cites W1965266378 @default.
- W3206081625 cites W1966239026 @default.
- W3206081625 cites W1967128626 @default.
- W3206081625 cites W1967479815 @default.
- W3206081625 cites W1967547250 @default.
- W3206081625 cites W1967724591 @default.
- W3206081625 cites W1967785546 @default.
- W3206081625 cites W1967871759 @default.
- W3206081625 cites W1967984219 @default.
- W3206081625 cites W1968355215 @default.
- W3206081625 cites W1971088282 @default.
- W3206081625 cites W1971343217 @default.
- W3206081625 cites W1971748223 @default.
- W3206081625 cites W1972702126 @default.
- W3206081625 cites W1972887736 @default.
- W3206081625 cites W1973034541 @default.
- W3206081625 cites W1973578428 @default.
- W3206081625 cites W1974014942 @default.
- W3206081625 cites W1974651655 @default.
- W3206081625 cites W1975475877 @default.
- W3206081625 cites W1975559128 @default.
- W3206081625 cites W1976113824 @default.
- W3206081625 cites W1978262597 @default.
- W3206081625 cites W1978715143 @default.
- W3206081625 cites W1980328470 @default.
- W3206081625 cites W1980921765 @default.
- W3206081625 cites W1981501770 @default.
- W3206081625 cites W1982041674 @default.
- W3206081625 cites W1983508616 @default.
- W3206081625 cites W1984418916 @default.
- W3206081625 cites W1984903735 @default.
- W3206081625 cites W1985017852 @default.
- W3206081625 cites W1985395264 @default.
- W3206081625 cites W1986133056 @default.
- W3206081625 cites W1986714953 @default.
- W3206081625 cites W1987123923 @default.
- W3206081625 cites W1987281985 @default.
- W3206081625 cites W1988030134 @default.
- W3206081625 cites W1989636443 @default.
- W3206081625 cites W1989707544 @default.
- W3206081625 cites W1989898499 @default.
- W3206081625 cites W1990642834 @default.
- W3206081625 cites W1991501943 @default.
- W3206081625 cites W1993035639 @default.
- W3206081625 cites W1993159752 @default.
- W3206081625 cites W1993658085 @default.
- W3206081625 cites W1993982563 @default.
- W3206081625 cites W1994852665 @default.
- W3206081625 cites W1994940669 @default.
- W3206081625 cites W1996009905 @default.
- W3206081625 cites W1996441425 @default.
- W3206081625 cites W1996442036 @default.
- W3206081625 cites W1996709540 @default.
- W3206081625 cites W1997303902 @default.
- W3206081625 cites W1997861308 @default.
- W3206081625 cites W1998269448 @default.
- W3206081625 cites W1998727316 @default.
- W3206081625 cites W1999078414 @default.
- W3206081625 cites W2000806899 @default.
- W3206081625 cites W200098830 @default.
- W3206081625 cites W2001089765 @default.
- W3206081625 cites W2001100581 @default.
- W3206081625 cites W2001217047 @default.
- W3206081625 cites W2001245625 @default.
- W3206081625 cites W2001439117 @default.
- W3206081625 cites W2001675633 @default.
- W3206081625 cites W2002018751 @default.
- W3206081625 cites W2003599729 @default.
- W3206081625 cites W2004674766 @default.
- W3206081625 cites W2004751476 @default.
- W3206081625 cites W2006604084 @default.
- W3206081625 cites W2007186776 @default.
- W3206081625 cites W2007246271 @default.
- W3206081625 cites W2007910963 @default.
- W3206081625 cites W2008887036 @default.
- W3206081625 cites W2009619936 @default.
- W3206081625 cites W2009774183 @default.
- W3206081625 cites W2010760005 @default.
- W3206081625 cites W2012474476 @default.
- W3206081625 cites W2015644894 @default.
- W3206081625 cites W201642989 @default.
- W3206081625 cites W2016632992 @default.
- W3206081625 cites W2019837353 @default.
- W3206081625 cites W2020088039 @default.
- W3206081625 cites W2020614754 @default.