FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206090868> ?p ?o ?g. }

• W3206090868 endingPage "1409" @default.
• W3206090868 startingPage "1409" @default.
• W3206090868 abstract "Ventricular Assist Device (VAD) therapy is considered as a part of standard care for end-stage Heart Failure (HF) children unresponsive to medical management, but the potential role of miRNAs in response to VAD therapy on molecular pathways underlying LV remodeling and cardiac function in HF is unknown. The aims of this study were to evaluate the effects of VAD on miRNA expression profile in cardiac tissue obtained from HF children, to determine the putative miRNA targets by an in-silico analysis as well as to verify the changes of predicated miRNA target in the same cardiac samples. The regulatory role of selected miRNAs on predicted targets was evaluated by a dedicated in vitro study. miRNA profile was determined in cardiac samples obtained from 13 HF children [median: 29 months; 19 LVEF%; 9 Kg] by NGS before VAD implant (pre-VAD) and at the moment of heart transplant (Post-VAD). Only hsa-miR-199b-5p, hsa-miR-19a-3p, hsa-miR-1246 were differentially expressed at post-VAD when compared to pre-VAD, and validated by real-time PCR. Putative targets of the selected miRNAs were involved in regulation of sarcomere genes, such as cardiac troponin (cTns) complex. The expression levels of fetal ad adult isoforms of cTns resulted significantly higher after VAD in cardiac tissue of HF pediatric patients when compared with HF adults. An in vitro study confirmed a down-regulatory effect of hsa-miR-19a-3p on cTnC expression. The effect of VAD on sarcomere organization through cTn isoform expression may be epigenetically regulated, suggesting for miRNAs a potential role as therapeutic targets to improve heart function in HF pediatric patients." @default.
• W3206090868 created "2021-10-25" @default.
• W3206090868 creator A5010784832 @default.
• W3206090868 creator A5011040459 @default.
• W3206090868 creator A5022839754 @default.
• W3206090868 creator A5027535170 @default.
• W3206090868 creator A5027942415 @default.
• W3206090868 creator A5041078416 @default.
• W3206090868 creator A5044930198 @default.
• W3206090868 creator A5046995998 @default.
• W3206090868 creator A5052245324 @default.
• W3206090868 creator A5069162270 @default.
• W3206090868 creator A5072430330 @default.
• W3206090868 creator A5085507482 @default.
• W3206090868 date "2021-10-07" @default.
• W3206090868 modified "2023-09-23" @default.
• W3206090868 title "Epigenetic Regulation of Cardiac Troponin Genes in Pediatric Patients with Heart Failure Supported by Ventricular Assist Device" @default.
• W3206090868 cites W1062333943 @default.
• W3206090868 cites W1987843933 @default.
• W3206090868 cites W2014203167 @default.
• W3206090868 cites W2014222556 @default.
• W3206090868 cites W2025243698 @default.
• W3206090868 cites W2029566138 @default.
• W3206090868 cites W2038331800 @default.
• W3206090868 cites W2058920533 @default.
• W3206090868 cites W2062613290 @default.
• W3206090868 cites W2073254471 @default.
• W3206090868 cites W2083381199 @default.
• W3206090868 cites W2084087358 @default.
• W3206090868 cites W2097255540 @default.
• W3206090868 cites W2099624330 @default.
• W3206090868 cites W2132093971 @default.
• W3206090868 cites W2133397439 @default.
• W3206090868 cites W2139834186 @default.
• W3206090868 cites W2179438025 @default.
• W3206090868 cites W2272054673 @default.
• W3206090868 cites W2339735627 @default.
• W3206090868 cites W2428968503 @default.
• W3206090868 cites W2579089971 @default.
• W3206090868 cites W2734322485 @default.
• W3206090868 cites W2759974103 @default.
• W3206090868 cites W2802920704 @default.
• W3206090868 cites W2806768805 @default.
• W3206090868 cites W2886279826 @default.
• W3206090868 cites W2946448066 @default.
• W3206090868 cites W3015120425 @default.
• W3206090868 cites W3087161706 @default.
• W3206090868 cites W3134280842 @default.
• W3206090868 doi "https://doi.org/10.3390/biomedicines9101409" @default.
• W3206090868 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8533380" @default.
• W3206090868 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34680526" @default.
• W3206090868 hasPublicationYear "2021" @default.
• W3206090868 type Work @default.
• W3206090868 sameAs 3206090868 @default.
• W3206090868 citedByCount "1" @default.
• W3206090868 countsByYear W32060908682023 @default.
• W3206090868 crossrefType "journal-article" @default.
• W3206090868 hasAuthorship W3206090868A5010784832 @default.
• W3206090868 hasAuthorship W3206090868A5011040459 @default.
• W3206090868 hasAuthorship W3206090868A5022839754 @default.
• W3206090868 hasAuthorship W3206090868A5027535170 @default.
• W3206090868 hasAuthorship W3206090868A5027942415 @default.
• W3206090868 hasAuthorship W3206090868A5041078416 @default.
• W3206090868 hasAuthorship W3206090868A5044930198 @default.
• W3206090868 hasAuthorship W3206090868A5046995998 @default.
• W3206090868 hasAuthorship W3206090868A5052245324 @default.
• W3206090868 hasAuthorship W3206090868A5069162270 @default.
• W3206090868 hasAuthorship W3206090868A5072430330 @default.
• W3206090868 hasAuthorship W3206090868A5085507482 @default.
• W3206090868 hasBestOaLocation W32060908681 @default.
• W3206090868 hasConcept C104317684 @default.
• W3206090868 hasConcept C111566952 @default.
• W3206090868 hasConcept C126322002 @default.
• W3206090868 hasConcept C144469398 @default.
• W3206090868 hasConcept C145059251 @default.
• W3206090868 hasConcept C164705383 @default.
• W3206090868 hasConcept C2775905019 @default.
• W3206090868 hasConcept C2778198053 @default.
• W3206090868 hasConcept C2781197716 @default.
• W3206090868 hasConcept C36036425 @default.
• W3206090868 hasConcept C41091548 @default.
• W3206090868 hasConcept C500558357 @default.
• W3206090868 hasConcept C54355233 @default.
• W3206090868 hasConcept C60644358 @default.
• W3206090868 hasConcept C71924100 @default.
• W3206090868 hasConcept C78085059 @default.
• W3206090868 hasConcept C86803240 @default.
• W3206090868 hasConceptScore W3206090868C104317684 @default.
• W3206090868 hasConceptScore W3206090868C111566952 @default.
• W3206090868 hasConceptScore W3206090868C126322002 @default.
• W3206090868 hasConceptScore W3206090868C144469398 @default.
• W3206090868 hasConceptScore W3206090868C145059251 @default.
• W3206090868 hasConceptScore W3206090868C164705383 @default.
• W3206090868 hasConceptScore W3206090868C2775905019 @default.
• W3206090868 hasConceptScore W3206090868C2778198053 @default.
• W3206090868 hasConceptScore W3206090868C2781197716 @default.
• W3206090868 hasConceptScore W3206090868C36036425 @default.
• W3206090868 hasConceptScore W3206090868C41091548 @default.

• next