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- W3206095816 abstract "Continuously dividing cells coordinate their growth and division. How fast cells grow in mass determines how fast they will multiply. Yet, there are few, if any, examples of a metabolic pathway that actively drives a cell cycle event instead of just being required for it. Here, we show that translational upregulation of lipogenic enzymes in Saccharomyces cerevisiae increased the abundance of lipids and promoted nuclear elongation and division. Derepressing translation of acetyl-CoA carboxylase and fatty acid synthase also suppressed cell cycle-related phenotypes, including delayed nuclear division, associated with Sec14p phosphatidylinositol transfer protein deficiencies, and the irregular nuclear morphologies of mutants defective in phosphatidylinositol 4-OH kinase activities. Our results show that increased lipogenesis drives a critical cell cycle landmark and report a phosphoinositide signaling axis in control of nuclear division. The broad conservation of these lipid metabolic and signaling pathways raises the possibility these activities similarly govern nuclear division in other eukaryotes." @default.
- W3206095816 created "2021-10-25" @default.
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- W3206095816 date "2021-10-09" @default.
- W3206095816 modified "2023-09-27" @default.
- W3206095816 title "Translational control of lipogenesis links protein synthesis and phosphoinositide signaling with nuclear division in <i>Saccharomyces cerevisiae</i>" @default.
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- W3206095816 doi "https://doi.org/10.1093/genetics/iyab171" @default.
- W3206095816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34849864" @default.
- W3206095816 hasPublicationYear "2021" @default.
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