FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206141883> ?p ?o ?g. }

• W3206141883 endingPage "1642" @default.
• W3206141883 startingPage "1632" @default.
• W3206141883 abstract "Background In some countries, breast cancer age-standardised mortality rates have decreased by 2–4% per year since the 1990s, but others have yet to achieve this outcome. In this study, we aimed to characterise the associations between national health system characteristics and breast cancer age-standardised mortality rate, and the degree of breast cancer downstaging correlating with national age-standardised mortality rate reductions. Methods In this population-based study, national age-standardised mortality rate estimates for women aged 69 years or younger obtained from GLOBOCAN 2020 were correlated with a broad panel of standardised national health system data as reported in the WHO Cancer Country Profiles 2020. These health system characteristics include health expenditure, the Universal Health Coverage Service Coverage Index (UHC Index), dedicated funding for early detection programmes, breast cancer early detection guidelines, referral systems, cancer plans, number of dedicated public and private cancer centres per 10 000 patients with cancer, and pathology services. We tested for differences between continuous variables using the non-parametric Kruskal-Wallis test, and for categorical variables using the Pearson χ2 test. Simple and multiple linear regression analyses were fitted to identify associations between health system characteristics and age-standardised breast cancer mortality rates. Data on TNM stage at diagnosis were obtained from national or subnational cancer registries, supplemented by a literature review of PubMed from 2010 to 2020. Mortality trends from 1950 to 2016 were assessed using the WHO Cancer Mortality Database. The threshold for significance was set at a p value of 0·05 or less. Findings 148 countries had complete health system data. The following variables were significantly higher in high-income countries than in low-income countries in unadjusted analyses: health expenditure (p=0·0002), UHC Index (p<0·0001), dedicated funding for early detection programmes (p=0·0020), breast cancer early detection guidelines (p<0·0001), breast cancer referral systems (p=0·0030), national cancer plans (p=0·014), cervical cancer early detection programmes (p=0·0010), number of dedicated public (p<0·0001) and private (p=0·027) cancer centres per 10 000 patients with cancer, and pathology services (p<0·0001). In adjusted multivariable regression analyses in 141 countries, two health system characteristics were significantly associated with lower age-standardised mortality rates: higher UHC Index levels (β=–0·12, 95% CI −0·16 to −0·08) and increasing numbers of public cancer centres (β=–0·23, −0·36 to −0·10). These findings indicate that each unit increase in the UHC Index was associated with a 0·12-unit decline in age-standardised mortality rates, and each additional public cancer centre per 10 000 patients with cancer was associated with a 0·23-unit decline in age-standardised mortality rate. Among 35 countries with available breast cancer TNM staging data, all 20 that achieved sustained mean reductions in age-standardised mortality rate of 2% or more per year for at least 3 consecutive years since 1990 had at least 60% of patients with invasive breast cancer presenting as stage I or II disease. Some countries achieved this reduction without most women having access to population-based mammographic screening. Interpretation Countries with low breast cancer mortality rates are characterised by increased levels of coverage of essential health services and higher numbers of public cancer centres. Among countries achieving sustained mortality reductions, the majority of breast cancers are diagnosed at an early stage, reinforcing the value of clinical early diagnosis programmes for improving breast cancer outcomes. Funding None." @default.
• W3206141883 created "2021-10-25" @default.
• W3206141883 creator A5003897511 @default.
• W3206141883 creator A5026861762 @default.
• W3206141883 creator A5033943753 @default.
• W3206141883 creator A5035150606 @default.
• W3206141883 creator A5063822600 @default.
• W3206141883 creator A5064215217 @default.
• W3206141883 creator A5087281739 @default.
• W3206141883 creator A5090808703 @default.
• W3206141883 date "2021-11-01" @default.
• W3206141883 modified "2023-10-16" @default.
• W3206141883 title "National health system characteristics, breast cancer stage at diagnosis, and breast cancer mortality: a population-based analysis" @default.
• W3206141883 cites W2045216597 @default.
• W3206141883 cites W2056494011 @default.
• W3206141883 cites W2067428007 @default.
• W3206141883 cites W2290344319 @default.
• W3206141883 cites W2402204373 @default.
• W3206141883 cites W2603868227 @default.
• W3206141883 cites W2775420644 @default.
• W3206141883 cites W2788268342 @default.
• W3206141883 cites W2917837889 @default.
• W3206141883 cites W2946421024 @default.
• W3206141883 cites W2979291688 @default.
• W3206141883 cites W2995833317 @default.
• W3206141883 cites W3012004398 @default.
• W3206141883 cites W3019318554 @default.
• W3206141883 cites W3020186439 @default.
• W3206141883 cites W3082803497 @default.
• W3206141883 cites W3131944761 @default.
• W3206141883 cites W3134519364 @default.
• W3206141883 doi "https://doi.org/10.1016/s1470-2045(21)00462-9" @default.
• W3206141883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34653370" @default.
• W3206141883 hasPublicationYear "2021" @default.
• W3206141883 type Work @default.
• W3206141883 sameAs 3206141883 @default.
• W3206141883 citedByCount "63" @default.
• W3206141883 countsByYear W32061418832021 @default.
• W3206141883 countsByYear W32061418832022 @default.
• W3206141883 countsByYear W32061418832023 @default.
• W3206141883 crossrefType "journal-article" @default.
• W3206141883 hasAuthorship W3206141883A5003897511 @default.
• W3206141883 hasAuthorship W3206141883A5026861762 @default.
• W3206141883 hasAuthorship W3206141883A5033943753 @default.
• W3206141883 hasAuthorship W3206141883A5035150606 @default.
• W3206141883 hasAuthorship W3206141883A5063822600 @default.
• W3206141883 hasAuthorship W3206141883A5064215217 @default.
• W3206141883 hasAuthorship W3206141883A5087281739 @default.
• W3206141883 hasAuthorship W3206141883A5090808703 @default.
• W3206141883 hasConcept C121608353 @default.
• W3206141883 hasConcept C126322002 @default.
• W3206141883 hasConcept C144024400 @default.
• W3206141883 hasConcept C149923435 @default.
• W3206141883 hasConcept C179755657 @default.
• W3206141883 hasConcept C207103383 @default.
• W3206141883 hasConcept C2776135927 @default.
• W3206141883 hasConcept C2777654188 @default.
• W3206141883 hasConcept C2778527826 @default.
• W3206141883 hasConcept C2908647359 @default.
• W3206141883 hasConcept C44249647 @default.
• W3206141883 hasConcept C512399662 @default.
• W3206141883 hasConcept C530470458 @default.
• W3206141883 hasConcept C71924100 @default.
• W3206141883 hasConcept C74909509 @default.
• W3206141883 hasConcept C99454951 @default.
• W3206141883 hasConceptScore W3206141883C121608353 @default.
• W3206141883 hasConceptScore W3206141883C126322002 @default.
• W3206141883 hasConceptScore W3206141883C144024400 @default.
• W3206141883 hasConceptScore W3206141883C149923435 @default.
• W3206141883 hasConceptScore W3206141883C179755657 @default.
• W3206141883 hasConceptScore W3206141883C207103383 @default.
• W3206141883 hasConceptScore W3206141883C2776135927 @default.
• W3206141883 hasConceptScore W3206141883C2777654188 @default.
• W3206141883 hasConceptScore W3206141883C2778527826 @default.
• W3206141883 hasConceptScore W3206141883C2908647359 @default.
• W3206141883 hasConceptScore W3206141883C44249647 @default.
• W3206141883 hasConceptScore W3206141883C512399662 @default.
• W3206141883 hasConceptScore W3206141883C530470458 @default.
• W3206141883 hasConceptScore W3206141883C71924100 @default.
• W3206141883 hasConceptScore W3206141883C74909509 @default.
• W3206141883 hasConceptScore W3206141883C99454951 @default.
• W3206141883 hasFunder F4320310728 @default.
• W3206141883 hasIssue "11" @default.
• W3206141883 hasLocation W32061418831 @default.
• W3206141883 hasLocation W32061418832 @default.
• W3206141883 hasOpenAccess W3206141883 @default.
• W3206141883 hasPrimaryLocation W32061418831 @default.
• W3206141883 hasRelatedWork W1966261153 @default.
• W3206141883 hasRelatedWork W2059042897 @default.
• W3206141883 hasRelatedWork W2068551140 @default.
• W3206141883 hasRelatedWork W2371771839 @default.
• W3206141883 hasRelatedWork W2380083969 @default.
• W3206141883 hasRelatedWork W2590224211 @default.
• W3206141883 hasRelatedWork W2904270633 @default.
• W3206141883 hasRelatedWork W3034493332 @default.
• W3206141883 hasRelatedWork W3049628195 @default.
• W3206141883 hasRelatedWork W4321478313 @default.
• W3206141883 hasVolume "22" @default.

• next