FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206144844> ?p ?o ?g. }

• W3206144844 endingPage "1250" @default.
• W3206144844 startingPage "1242" @default.
• W3206144844 abstract "Patients with rheumatoid arthritis (RA) have an increased risk of venous thromboembolism (VTE), likely related to underlying inflammation. We examined VTE risk associated with two commonly used immunomodulators in RA patients, methotrexate and hydroxychloroquine.Using U.S. Medicare claims data (2008-2017), we identified RA patients (≥65 years) who initiated methotrexate or hydroxychloroquine without prior use of any immunomodulators. The primary outcome was VTE, a composite of pulmonary embolism (PE) or deep vein thrombosis (DVT). Secondary outcomes included PE, DVT, and all-cause mortality. After 1:1 propensity score matching for confounding control, we identified 26,534 pairs of methotrexate and hydroxychloroquine initiators (mean (SD) age 74 (7) years; 79% female). During a total of 56,686 person-years of follow-up, 208 methotrexate and 83 hydroxychloroquine initiators developed VTE. The incidence rate of VTE was higher among methotrexate initiators (6.94/1,000 person-years) than hydroxychloroquine initiators (3.11/1,000 person-years) with a hazard ratio (HR) of 2.26 (95% CI 1.75, 2.91). Methotrexate initiators had a greater risk of PE (HR 3.30, 95% CI 2.28, 4.77) and DVT (HR 1.53, 95% CI 1.07, 2.19) than hydroxychloroquine initiators. All-cause mortality was similar between the two groups (HR 0.91, 95% CI 0.83, 1.00).In this large real-world cohort of older RA patients, treatment with methotrexate was associated with a 2-fold increased risk of VTE relative to hydroxychloroquine, although all-cause mortality was similar. Future experimental studies with non-user control groups are needed to determine the causal relationships between the study drugs and VTE and whether methotrexate elevates or hydroxychloroquine reduces the risk of VTE." @default.
• W3206144844 created "2021-10-25" @default.
• W3206144844 creator A5008078906 @default.
• W3206144844 creator A5009688412 @default.
• W3206144844 creator A5021540912 @default.
• W3206144844 creator A5029417325 @default.
• W3206144844 creator A5037322697 @default.
• W3206144844 creator A5047117557 @default.
• W3206144844 creator A5050398307 @default.
• W3206144844 creator A5088217101 @default.
• W3206144844 date "2021-12-01" @default.
• W3206144844 modified "2023-09-29" @default.
• W3206144844 title "Risk of venous thromboembolism associated with methotrexate versus hydroxychloroquine for rheumatoid arthritis: A propensity score-matched cohort study" @default.
• W3206144844 cites W100033204 @default.
• W3206144844 cites W1539877514 @default.
• W3206144844 cites W1572727384 @default.
• W3206144844 cites W1606460889 @default.
• W3206144844 cites W1849521086 @default.
• W3206144844 cites W1974563253 @default.
• W3206144844 cites W1980669153 @default.
• W3206144844 cites W1991433622 @default.
• W3206144844 cites W2001727746 @default.
• W3206144844 cites W2010352517 @default.
• W3206144844 cites W2020122535 @default.
• W3206144844 cites W2065276135 @default.
• W3206144844 cites W2068265433 @default.
• W3206144844 cites W2087018232 @default.
• W3206144844 cites W2090465797 @default.
• W3206144844 cites W2098986981 @default.
• W3206144844 cites W2111714917 @default.
• W3206144844 cites W2115004354 @default.
• W3206144844 cites W2134766532 @default.
• W3206144844 cites W2140707981 @default.
• W3206144844 cites W2142004396 @default.
• W3206144844 cites W2150291618 @default.
• W3206144844 cites W2155123856 @default.
• W3206144844 cites W2166854766 @default.
• W3206144844 cites W2171357097 @default.
• W3206144844 cites W2176057385 @default.
• W3206144844 cites W2606267946 @default.
• W3206144844 cites W2609185034 @default.
• W3206144844 cites W2733606048 @default.
• W3206144844 cites W2735121175 @default.
• W3206144844 cites W2735301415 @default.
• W3206144844 cites W2799522017 @default.
• W3206144844 cites W2800826112 @default.
• W3206144844 cites W2899885364 @default.
• W3206144844 cites W2928282096 @default.
• W3206144844 cites W2936013463 @default.
• W3206144844 cites W3003777738 @default.
• W3206144844 cites W3005497321 @default.
• W3206144844 cites W3036169639 @default.
• W3206144844 cites W3049449687 @default.
• W3206144844 cites W3096804185 @default.
• W3206144844 cites W3111250088 @default.
• W3206144844 cites W4231972505 @default.
• W3206144844 doi "https://doi.org/10.1016/j.semarthrit.2021.10.001" @default.
• W3206144844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34757241" @default.
• W3206144844 hasPublicationYear "2021" @default.
• W3206144844 type Work @default.
• W3206144844 sameAs 3206144844 @default.
• W3206144844 citedByCount "6" @default.
• W3206144844 countsByYear W32061448442022 @default.
• W3206144844 countsByYear W32061448442023 @default.
• W3206144844 crossrefType "journal-article" @default.
• W3206144844 hasAuthorship W3206144844A5008078906 @default.
• W3206144844 hasAuthorship W3206144844A5009688412 @default.
• W3206144844 hasAuthorship W3206144844A5021540912 @default.
• W3206144844 hasAuthorship W3206144844A5029417325 @default.
• W3206144844 hasAuthorship W3206144844A5037322697 @default.
• W3206144844 hasAuthorship W3206144844A5047117557 @default.
• W3206144844 hasAuthorship W3206144844A5050398307 @default.
• W3206144844 hasAuthorship W3206144844A5088217101 @default.
• W3206144844 hasConcept C126322002 @default.
• W3206144844 hasConcept C141071460 @default.
• W3206144844 hasConcept C17923572 @default.
• W3206144844 hasConcept C207103383 @default.
• W3206144844 hasConcept C2776265017 @default.
• W3206144844 hasConcept C2777575956 @default.
• W3206144844 hasConcept C2779123688 @default.
• W3206144844 hasConcept C2779134260 @default.
• W3206144844 hasConcept C2781059491 @default.
• W3206144844 hasConcept C3008058167 @default.
• W3206144844 hasConcept C44249647 @default.
• W3206144844 hasConcept C524204448 @default.
• W3206144844 hasConcept C71924100 @default.
• W3206144844 hasConcept C72563966 @default.
• W3206144844 hasConceptScore W3206144844C126322002 @default.
• W3206144844 hasConceptScore W3206144844C141071460 @default.
• W3206144844 hasConceptScore W3206144844C17923572 @default.
• W3206144844 hasConceptScore W3206144844C207103383 @default.
• W3206144844 hasConceptScore W3206144844C2776265017 @default.
• W3206144844 hasConceptScore W3206144844C2777575956 @default.
• W3206144844 hasConceptScore W3206144844C2779123688 @default.
• W3206144844 hasConceptScore W3206144844C2779134260 @default.
• W3206144844 hasConceptScore W3206144844C2781059491 @default.
• W3206144844 hasConceptScore W3206144844C3008058167 @default.
• W3206144844 hasConceptScore W3206144844C44249647 @default.

• next