Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206151437> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W3206151437 endingPage "S1150" @default.
- W3206151437 startingPage "S1149" @default.
- W3206151437 abstract "Precise diagnosis of the tissue origin for metastatic carcinoma is essential to decide the treatment scheme and improve outcome. The purpose of this study is to predict the primary site for lung-specific cancer of unknown primary (CUP) through genomic and DNA methylation profiles. Comprehensive genomic profiling (CGP) was performed to determine the genomic status within individual paired samples, and targeted bisulfite sequencing was exploited to interrogate their methylation status. Model training subjects were consisted of lung cancer and another type of cancer to compute the prediction signature weights for each DMR feature. A total of 300 patients with multi-site malignancies including lung and other organ lesions were screened retrospectively. Excluding individuals clearly diagnosed with imaging modalities and IHC staining, 40 patients needed further differential diagnosis. Among them, 26 cases were identified with novel molecular events like EGFR or ALK alterations; the remaining 14 lung-specific CUPs were located with another type of caners in stomach (n=5), intestine (n=5) and cervix (n=4). Of the 14 CUP cases, mutation spectrum analyses could distinguish metastatic disease from multiple primary tumors, while it was hard to determine the origin of metastatic cancers. However, methylation profiles not only predicted the consistent results with mutation spectrum, but also identified the origin of tumors through our train classification models (AUC>0.98), which can be confirmed with patients’ clinical efficacy who received treatments guided by prediction signature. Collectively, compared with genomic profiles, DNA methylation demonstrated better tumor traceability to determine the primary site of CUPs. The signature based on within-sample CGP testing optimized with DNA methylation could exactly identify the origin of lung-specific CUPs." @default.
- W3206151437 created "2021-10-25" @default.
- W3206151437 creator A5038234724 @default.
- W3206151437 creator A5055144615 @default.
- W3206151437 date "2021-10-01" @default.
- W3206151437 modified "2023-10-16" @default.
- W3206151437 title "P59.08 Identifying the Origin of Lung-Specific Cancer of Unknown Primary Based on Comprehensive Genomic Profiling Optimized With DNA Methylation" @default.
- W3206151437 doi "https://doi.org/10.1016/j.jtho.2021.08.597" @default.
- W3206151437 hasPublicationYear "2021" @default.
- W3206151437 type Work @default.
- W3206151437 sameAs 3206151437 @default.
- W3206151437 citedByCount "0" @default.
- W3206151437 crossrefType "journal-article" @default.
- W3206151437 hasAuthorship W3206151437A5038234724 @default.
- W3206151437 hasAuthorship W3206151437A5055144615 @default.
- W3206151437 hasBestOaLocation W32061514371 @default.
- W3206151437 hasConcept C104317684 @default.
- W3206151437 hasConcept C121608353 @default.
- W3206151437 hasConcept C126322002 @default.
- W3206151437 hasConcept C142724271 @default.
- W3206151437 hasConcept C143998085 @default.
- W3206151437 hasConcept C150194340 @default.
- W3206151437 hasConcept C17757408 @default.
- W3206151437 hasConcept C190727270 @default.
- W3206151437 hasConcept C2776256026 @default.
- W3206151437 hasConcept C2777546739 @default.
- W3206151437 hasConcept C2779013556 @default.
- W3206151437 hasConcept C2780283643 @default.
- W3206151437 hasConcept C2781182431 @default.
- W3206151437 hasConcept C33288867 @default.
- W3206151437 hasConcept C54355233 @default.
- W3206151437 hasConcept C552990157 @default.
- W3206151437 hasConcept C71924100 @default.
- W3206151437 hasConcept C86803240 @default.
- W3206151437 hasConceptScore W3206151437C104317684 @default.
- W3206151437 hasConceptScore W3206151437C121608353 @default.
- W3206151437 hasConceptScore W3206151437C126322002 @default.
- W3206151437 hasConceptScore W3206151437C142724271 @default.
- W3206151437 hasConceptScore W3206151437C143998085 @default.
- W3206151437 hasConceptScore W3206151437C150194340 @default.
- W3206151437 hasConceptScore W3206151437C17757408 @default.
- W3206151437 hasConceptScore W3206151437C190727270 @default.
- W3206151437 hasConceptScore W3206151437C2776256026 @default.
- W3206151437 hasConceptScore W3206151437C2777546739 @default.
- W3206151437 hasConceptScore W3206151437C2779013556 @default.
- W3206151437 hasConceptScore W3206151437C2780283643 @default.
- W3206151437 hasConceptScore W3206151437C2781182431 @default.
- W3206151437 hasConceptScore W3206151437C33288867 @default.
- W3206151437 hasConceptScore W3206151437C54355233 @default.
- W3206151437 hasConceptScore W3206151437C552990157 @default.
- W3206151437 hasConceptScore W3206151437C71924100 @default.
- W3206151437 hasConceptScore W3206151437C86803240 @default.
- W3206151437 hasIssue "10" @default.
- W3206151437 hasLocation W32061514371 @default.
- W3206151437 hasOpenAccess W3206151437 @default.
- W3206151437 hasPrimaryLocation W32061514371 @default.
- W3206151437 hasRelatedWork W1603166532 @default.
- W3206151437 hasRelatedWork W1964017123 @default.
- W3206151437 hasRelatedWork W2089266214 @default.
- W3206151437 hasRelatedWork W2149506551 @default.
- W3206151437 hasRelatedWork W2794651804 @default.
- W3206151437 hasRelatedWork W2904515903 @default.
- W3206151437 hasRelatedWork W2991864465 @default.
- W3206151437 hasRelatedWork W3086917908 @default.
- W3206151437 hasRelatedWork W3118746383 @default.
- W3206151437 hasRelatedWork W4237783600 @default.
- W3206151437 hasVolume "16" @default.
- W3206151437 isParatext "false" @default.
- W3206151437 isRetracted "false" @default.
- W3206151437 magId "3206151437" @default.
- W3206151437 workType "article" @default.