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- W3206153439 abstract "Abstract Among a cluster of COVID-19 cases from the end of March through April 2021 in Asahikawa, we experienced the cases in which patients manifested severe clinical symptoms compared to patients who were infected before that. A hundred three patients (age range: 65 to 89 years old) enrolled in this study were divided into two groups, group A: the patients infected from November 2020 to March 2021, and group B: the patients in this cluster population. The mortality rates were 6.1% in group A and 16.2% in group B (OR: 2.97, 95%CI: 0.65-15.38). For the severity of disease, the patients in group B required higher oxygen flow rate in early course of admission (mild; p=0.892, moderate; p=0.117, severe; p=0.029). Whole viral genome sequences revealed five non-synonymous mutations by comparison of the isolates with each group. Of these, four were on non-structural proteins (NSPs) including nsp3, 6 and 15, and one was on S protein located near the C-terminus, suggesting that the mutations on NSPs could be responsible for adverse clinical outcomes in COVID-19 patients." @default.
- W3206153439 created "2021-10-25" @default.
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- W3206153439 date "2021-10-20" @default.
- W3206153439 modified "2023-10-06" @default.
- W3206153439 title "Mutations on non-structural proteins of SARS-CoV-2 are possibly responsible for adverse clinical outcomes" @default.
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- W3206153439 doi "https://doi.org/10.1101/2021.10.19.21265062" @default.
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