FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206155087> ?p ?o ?g. }

• W3206155087 abstract "In an aging population, intense interest has shifted toward prolonging health span. Mounting evidence suggests that cellular reactive species are propagators of cell damage, inflammation, and cellular senescence. Thus, such species have emerged as putative provocateurs and targets for senolysis, and a clearer understanding of their molecular origin and regulation is of paramount importance. In an inquiry into signaling triggered by aging and proxy instigator, hyperglycemia, we show that NADPH Oxidase (NOX) drives cell DNA damage and alters nuclear envelope integrity, inflammation, tissue dysfunction, and cellular senescence in mice and humans with similar causality. Most notably, selective NOX1 inhibition rescues age-impaired blood flow and angiogenesis, vasodilation, and the endothelial cell wound response. Indeed, NOX1i delivery in vivo completely reversed age-impaired hind-limb blood flow and angiogenesis while disrupting a NOX1-IL-6 senescence-associated secretory phenotype (SASP) proinflammatory signaling loop. Relevant to its comorbidity with age, clinical samples from diabetic versus nondiabetic subjects reveal as operant this NOX1-mediated vascular senescence and inflammation in humans. On a mechanistic level, our findings support a previously unidentified role for IL-6 in this feedforward inflammatory loop and peroxisome proliferator-activated receptor gamma (PPARγ) down-regulation as inversely modulating p65-mediated NOX1 transcription. Targeting this previously unidentified NOX1-SASP signaling axis in aging is predicted to be an effective strategy for mitigating senescence in the vasculature and other organ systems." @default.
• W3206155087 created "2021-10-25" @default.
• W3206155087 creator A5003021767 @default.
• W3206155087 creator A5003602771 @default.
• W3206155087 creator A5011179194 @default.
• W3206155087 creator A5011455927 @default.
• W3206155087 creator A5015688526 @default.
• W3206155087 creator A5030673899 @default.
• W3206155087 creator A5034559313 @default.
• W3206155087 creator A5046113390 @default.
• W3206155087 creator A5057837748 @default.
• W3206155087 creator A5063279911 @default.
• W3206155087 creator A5070113172 @default.
• W3206155087 creator A5070350398 @default.
• W3206155087 creator A5079581156 @default.
• W3206155087 creator A5088020586 @default.
• W3206155087 date "2021-10-15" @default.
• W3206155087 modified "2023-10-04" @default.
• W3206155087 title "Forestalling age-impaired angiogenesis and blood flow by targeting NOX: Interplay of NOX1, IL-6, and SASP in propagating cell senescence" @default.
• W3206155087 cites W1958721091 @default.
• W3206155087 cites W1970676428 @default.
• W3206155087 cites W1970891016 @default.
• W3206155087 cites W1990423201 @default.
• W3206155087 cites W2000293915 @default.
• W3206155087 cites W2000396381 @default.
• W3206155087 cites W2010461435 @default.
• W3206155087 cites W2011124873 @default.
• W3206155087 cites W2013287222 @default.
• W3206155087 cites W2013636493 @default.
• W3206155087 cites W2021660616 @default.
• W3206155087 cites W2025966812 @default.
• W3206155087 cites W2027379853 @default.
• W3206155087 cites W2028732979 @default.
• W3206155087 cites W2030474005 @default.
• W3206155087 cites W2047852384 @default.
• W3206155087 cites W2049206418 @default.
• W3206155087 cites W2049680139 @default.
• W3206155087 cites W2055207018 @default.
• W3206155087 cites W2056014395 @default.
• W3206155087 cites W2056620406 @default.
• W3206155087 cites W2068403201 @default.
• W3206155087 cites W2085132789 @default.
• W3206155087 cites W2088062477 @default.
• W3206155087 cites W2097750015 @default.
• W3206155087 cites W2104721620 @default.
• W3206155087 cites W2113764806 @default.
• W3206155087 cites W2115852450 @default.
• W3206155087 cites W2116462934 @default.
• W3206155087 cites W2118874116 @default.
• W3206155087 cites W2121619780 @default.
• W3206155087 cites W2122734862 @default.
• W3206155087 cites W2135564059 @default.
• W3206155087 cites W2138551135 @default.
• W3206155087 cites W2160279897 @default.
• W3206155087 cites W2162285932 @default.
• W3206155087 cites W2162583612 @default.
• W3206155087 cites W2164444293 @default.
• W3206155087 cites W2164879283 @default.
• W3206155087 cites W2166665077 @default.
• W3206155087 cites W2289876562 @default.
• W3206155087 cites W2295084748 @default.
• W3206155087 cites W2325332831 @default.
• W3206155087 cites W2544670169 @default.
• W3206155087 cites W2569107931 @default.
• W3206155087 cites W2592371738 @default.
• W3206155087 cites W2603975044 @default.
• W3206155087 cites W2756868862 @default.
• W3206155087 cites W2767034640 @default.
• W3206155087 cites W2767885122 @default.
• W3206155087 cites W2792237486 @default.
• W3206155087 cites W2803815839 @default.
• W3206155087 cites W2806200027 @default.
• W3206155087 cites W2891409258 @default.
• W3206155087 cites W2916479673 @default.
• W3206155087 cites W2954246968 @default.
• W3206155087 cites W2962991457 @default.
• W3206155087 cites W2977696708 @default.
• W3206155087 cites W2978270346 @default.
• W3206155087 cites W3005923011 @default.
• W3206155087 cites W3035131221 @default.
• W3206155087 cites W3037426896 @default.
• W3206155087 cites W3093983823 @default.
• W3206155087 cites W3145335182 @default.
• W3206155087 cites W3146392721 @default.
• W3206155087 cites W4256530495 @default.
• W3206155087 cites W4368139337 @default.
• W3206155087 doi "https://doi.org/10.1073/pnas.2015666118" @default.
• W3206155087 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8594573" @default.
• W3206155087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34654740" @default.
• W3206155087 hasPublicationYear "2021" @default.
• W3206155087 type Work @default.
• W3206155087 sameAs 3206155087 @default.
• W3206155087 citedByCount "15" @default.
• W3206155087 countsByYear W32061550872021 @default.
• W3206155087 countsByYear W32061550872022 @default.
• W3206155087 countsByYear W32061550872023 @default.
• W3206155087 crossrefType "journal-article" @default.
• W3206155087 hasAuthorship W3206155087A5003021767 @default.
• W3206155087 hasAuthorship W3206155087A5003602771 @default.
• W3206155087 hasAuthorship W3206155087A5011179194 @default.

• next