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- W3206178135 abstract "Methicillin-resistant Staphylococcus pseudintermedius (MRSP) is an important emerging zoonotic pathogen that causes severe skin infections. To combat infections from drug-resistant bacteria, the transplantation of commensal antimicrobial bacteria as a therapeutic has shown clinical promise. We screened a collection of diverse staphylococcus species from domestic dogs and cats for antimicrobial activity against MRSP. A unique strain (S. felis C4) was isolated from feline skin that inhibited MRSP and multiple gram-positive pathogens. Whole genome sequencing and mass spectrometry revealed several secreted antimicrobials including a thiopeptide bacteriocin micrococcin P1 and phenol-soluble modulin beta (PSMβ) peptides that exhibited antimicrobial and anti-inflammatory activity. Fluorescence and electron microscopy revealed that S. felis antimicrobials inhibited translation and disrupted bacterial but not eukaryotic cell membranes. Competition experiments in mice showed that S. felis significantly reduced MRSP skin colonization and an antimicrobial extract from S. felis significantly reduced necrotic skin injury from MRSP infection. These findings indicate a feline commensal bacterium that could be utilized in bacteriotherapy against difficult-to-treat animal and human skin infections." @default.
- W3206178135 created "2021-10-25" @default.
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- W3206178135 date "2021-10-19" @default.
- W3206178135 modified "2023-10-16" @default.
- W3206178135 title "Antimicrobials from a feline commensal bacterium inhibit skin infection by drug-resistant S. pseudintermedius" @default.
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- W3206178135 doi "https://doi.org/10.7554/elife.66793" @default.
- W3206178135 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8592530" @default.