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- W3206179195 abstract "Human apolipoprotein E (ApoE) genotype is the only confirmed genetic risk factor for Alzheimer's disease. As the most common isoform, ApoE3 is believed to play a neutral role in AD, while ApoE4 exists in nearly 50% of AD patients. On the other hand ApoE2 is relatively rare and is considered to be a protective variant against AD via its effects on Amyloid beta metabolism. In this retrospective longitudinal study we analyzed a population inside of the AD continuum to investigate the effect of these Epsilon variants on the CSF biomarkers trending levels." @default.
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- W3206179195 date "2021-10-01" @default.
- W3206179195 modified "2023-09-26" @default.
- W3206179195 title "Does ApoE 2 polymorphism play a protective role against Alzheimer's disease?" @default.
- W3206179195 doi "https://doi.org/10.1016/j.jns.2021.119021" @default.
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