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• W3206203949 startingPage "49642" @default.
• W3206203949 abstract "Periodontitis compromises the integrity and function of tooth-supporting structures. Although therapeutic approaches have been offered, predictable regeneration of periodontal tissues remains intangible, particularly in anatomically complex defects. In this work, personalized and defect-specific antibiotic-laden polymeric scaffolds containing metronidazole (MET), tetracycline (TCH), or their combination (MET/TCH) were created via electrospinning. An initial screening of the synthesized fibers comprising chemo-morphological analyses, cytocompatibility assessment, and antimicrobial validation against periodontopathogens was accomplished to determine the cell-friendly and anti-infective nature of the scaffolds. According to the cytocompatibility and antimicrobial data, the 1:3 MET/TCH formulation was used to obtain three-dimensional defect-specific scaffolds to treat periodontally compromised three-wall osseous defects in rats. Inflammatory cell response and new bone formation were assessed by histology. Micro-computerized tomography was performed to assess bone loss in the furcation area at 2 and 6 weeks post implantation. Chemo-morphological and cell compatibility analyses confirmed the synthesis of cytocompatible antibiotic-laden fibers with antimicrobial action. Importantly, the 1:3 MET/TCH defect-specific scaffolds led to increased new bone formation, lower bone loss, and reduced inflammatory response when compared to antibiotic-free scaffolds. Altogether, our results suggest that the fabrication of defect-specific antibiotic-laden scaffolds holds great potential toward the development of personalized (i.e., patient-specific medication) scaffolds to ablate infection while affording regenerative properties." @default.
• W3206203949 created "2021-10-25" @default.
• W3206203949 creator A5004584743 @default.
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• W3206203949 date "2021-10-12" @default.
• W3206203949 modified "2023-10-15" @default.
• W3206203949 title "Personalized and Defect-Specific Antibiotic-Laden Scaffolds for Periodontal Infection Ablation" @default.
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• W3206203949 doi "https://doi.org/10.1021/acsami.1c11787" @default.
• W3206203949 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34637255" @default.

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