FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206218192> ?p ?o ?g. }

• W3206218192 endingPage "19" @default.
• W3206218192 startingPage "1" @default.
• W3206218192 abstract "Cyclooxygenase-2 (COX-2) is an inducible inflammatory enzyme, which produces prostanoids from arachidonic acid. COX-2 overexpression and over-activity can cause inflammation, tumorigenesis, and angiogenesis. Prostanoids are the main reason for the inflammation, and increase of mitogenesis by COX-2. So, any change such as mutations that can lead to COX-2 over-activity could ignite the tumor situations with increase of prostanoids production is one of its ways. The aim of this study was to check the effect of 166 missense mutations of COX-2 on protein features that can affect the COX-2 activity such as protein stability, fluctuation, 2D structure, and its binding affinity with the substrate by in silico methods, network modeling, and docking calculations, by which 44 of them shown to be deleterious. Among them, the S124I and S474F mutations can increase the stability of the protein. 11.36% of deleterious nsSNPs were part of the substrate-binding region among which the M508T, H337R, and V511G have the potential to affect the protein by 2D structure alteration. V511G can improve binding affinity and H337R showed a small decrease in the deformation overall energy that can represent a decrease in the stability of COX-2. Also, L517S showed a significant decrease in the binding power of COX-2/substrate but based on the anisotropic network modeling this mutation has a dual effect on COX-2 stability. These nsSNPs/mutations have the potential causing an increase or decrease of tumorigenesis because increasing of COX-2 stability and its binding affinity can lead to altering its activity." @default.
• W3206218192 created "2021-10-25" @default.
• W3206218192 creator A5023231488 @default.
• W3206218192 creator A5061568123 @default.
• W3206218192 creator A5062041322 @default.
• W3206218192 creator A5069701018 @default.
• W3206218192 date "2021-10-11" @default.
• W3206218192 modified "2023-09-26" @default.
• W3206218192 title "Missense mutations involvement in COX-2 structure, and protein-substrate binding affinity: in-silico study" @default.
• W3206218192 cites W1491040459 @default.
• W3206218192 cites W1529802913 @default.
• W3206218192 cites W1563940013 @default.
• W3206218192 cites W156631889 @default.
• W3206218192 cites W1970351453 @default.
• W3206218192 cites W1972115991 @default.
• W3206218192 cites W1975092906 @default.
• W3206218192 cites W1979878592 @default.
• W3206218192 cites W1983692335 @default.
• W3206218192 cites W1990144502 @default.
• W3206218192 cites W1991762941 @default.
• W3206218192 cites W1994981556 @default.
• W3206218192 cites W1995648971 @default.
• W3206218192 cites W2004377868 @default.
• W3206218192 cites W2007195739 @default.
• W3206218192 cites W2021767971 @default.
• W3206218192 cites W2024405748 @default.
• W3206218192 cites W2032626077 @default.
• W3206218192 cites W2038163496 @default.
• W3206218192 cites W2038451050 @default.
• W3206218192 cites W2043855224 @default.
• W3206218192 cites W2050310941 @default.
• W3206218192 cites W2057659399 @default.
• W3206218192 cites W2067378195 @default.
• W3206218192 cites W2069777230 @default.
• W3206218192 cites W2072000048 @default.
• W3206218192 cites W2074454712 @default.
• W3206218192 cites W2080553628 @default.
• W3206218192 cites W2081521523 @default.
• W3206218192 cites W2085344563 @default.
• W3206218192 cites W2099564671 @default.
• W3206218192 cites W2100984467 @default.
• W3206218192 cites W2111854851 @default.
• W3206218192 cites W2113994268 @default.
• W3206218192 cites W2120230374 @default.
• W3206218192 cites W2127981150 @default.
• W3206218192 cites W2140428787 @default.
• W3206218192 cites W2143883087 @default.
• W3206218192 cites W2148455468 @default.
• W3206218192 cites W2149233326 @default.
• W3206218192 cites W2153304705 @default.
• W3206218192 cites W2160782760 @default.
• W3206218192 cites W2164004777 @default.
• W3206218192 cites W2164883596 @default.
• W3206218192 cites W2297796190 @default.
• W3206218192 cites W2301197921 @default.
• W3206218192 cites W2438455430 @default.
• W3206218192 cites W2726456901 @default.
• W3206218192 cites W2753346835 @default.
• W3206218192 cites W2795332779 @default.
• W3206218192 cites W2898079638 @default.
• W3206218192 cites W2914359786 @default.
• W3206218192 cites W2925275193 @default.
• W3206218192 cites W2990165277 @default.
• W3206218192 cites W3002361764 @default.
• W3206218192 cites W3096371820 @default.
• W3206218192 cites W4254753097 @default.
• W3206218192 doi "https://doi.org/10.1080/15257770.2021.1983826" @default.
• W3206218192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34632961" @default.
• W3206218192 hasPublicationYear "2021" @default.
• W3206218192 type Work @default.
• W3206218192 sameAs 3206218192 @default.
• W3206218192 citedByCount "0" @default.
• W3206218192 crossrefType "journal-article" @default.
• W3206218192 hasAuthorship W3206218192A5023231488 @default.
• W3206218192 hasAuthorship W3206218192A5061568123 @default.
• W3206218192 hasAuthorship W3206218192A5062041322 @default.
• W3206218192 hasAuthorship W3206218192A5069701018 @default.
• W3206218192 hasConcept C104317684 @default.
• W3206218192 hasConcept C12554922 @default.
• W3206218192 hasConcept C181199279 @default.
• W3206218192 hasConcept C185592680 @default.
• W3206218192 hasConcept C2775905019 @default.
• W3206218192 hasConcept C2779689624 @default.
• W3206218192 hasConcept C502942594 @default.
• W3206218192 hasConcept C55493867 @default.
• W3206218192 hasConcept C555283112 @default.
• W3206218192 hasConcept C86803240 @default.
• W3206218192 hasConceptScore W3206218192C104317684 @default.
• W3206218192 hasConceptScore W3206218192C12554922 @default.
• W3206218192 hasConceptScore W3206218192C181199279 @default.
• W3206218192 hasConceptScore W3206218192C185592680 @default.
• W3206218192 hasConceptScore W3206218192C2775905019 @default.
• W3206218192 hasConceptScore W3206218192C2779689624 @default.
• W3206218192 hasConceptScore W3206218192C502942594 @default.
• W3206218192 hasConceptScore W3206218192C55493867 @default.
• W3206218192 hasConceptScore W3206218192C555283112 @default.
• W3206218192 hasConceptScore W3206218192C86803240 @default.
• W3206218192 hasLocation W32062181921 @default.

• next