Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206226737> ?p ?o ?g. }
- W3206226737 endingPage "4793" @default.
- W3206226737 startingPage "4793" @default.
- W3206226737 abstract "The recognition and management of life-threatening hemorrhage in the polytrauma patient poses several challenges to prehospital rescue personnel and hospital providers. First, identification of acute blood loss and the magnitude of lost volume after torso injury may not be readily apparent in the field. Because of the expression of highly effective physiological mechanisms that compensate for a sudden decrease in circulatory volume, a polytrauma patient with a significant blood loss may appear normal during examination by first responders. Consequently, for every polytrauma victim with a significant mechanism of injury we assume substantial blood loss has occurred and life-threatening hemorrhage is progressing until we can prove the contrary. Second, a decision to begin damage control resuscitation (DCR), a costly, highly complex, and potentially dangerous intervention must often be reached with little time and without sufficient clinical information about the intended recipient. Whether to begin DCR in the prehospital phase remains controversial. Furthermore, DCR executed imperfectly has the potential to worsen serious derangements including acidosis, coagulopathy, and profound homeostatic imbalances that DCR is designed to correct. Additionally, transfusion of large amounts of homologous blood during DCR potentially disrupts immune and inflammatory systems, which may induce severe systemic autoinflammatory disease in the aftermath of DCR. Third, controversy remains over the composition of components that are transfused during DCR. For practical reasons, unmatched liquid plasma or freeze-dried plasma is transfused now more commonly than ABO-matched fresh frozen plasma. Low-titer type O whole blood may prove safer than red cell components, although maintaining an inventory of whole blood for possible massive transfusion during DCR creates significant challenges for blood banks. Lastly, as the primary principle of management of life-threatening hemorrhage is surgical or angiographic control of bleeding, DCR must not eclipse these definitive interventions." @default.
- W3206226737 created "2021-10-25" @default.
- W3206226737 creator A5011799792 @default.
- W3206226737 creator A5017377916 @default.
- W3206226737 creator A5068622451 @default.
- W3206226737 creator A5082817481 @default.
- W3206226737 date "2021-10-19" @default.
- W3206226737 modified "2023-09-27" @default.
- W3206226737 title "The Pathophysiology and Management of Hemorrhagic Shock in the Polytrauma Patient" @default.
- W3206226737 cites W1542355716 @default.
- W3206226737 cites W1572037713 @default.
- W3206226737 cites W1600234741 @default.
- W3206226737 cites W16089093 @default.
- W3206226737 cites W1647351543 @default.
- W3206226737 cites W1666870061 @default.
- W3206226737 cites W1763133400 @default.
- W3206226737 cites W1774861407 @default.
- W3206226737 cites W1898858786 @default.
- W3206226737 cites W1918566820 @default.
- W3206226737 cites W1939149497 @default.
- W3206226737 cites W1966172124 @default.
- W3206226737 cites W1966802506 @default.
- W3206226737 cites W1967433109 @default.
- W3206226737 cites W1968011284 @default.
- W3206226737 cites W1970362985 @default.
- W3206226737 cites W1970569414 @default.
- W3206226737 cites W1971410089 @default.
- W3206226737 cites W1974693697 @default.
- W3206226737 cites W1977966723 @default.
- W3206226737 cites W1978890822 @default.
- W3206226737 cites W1978958680 @default.
- W3206226737 cites W1979626640 @default.
- W3206226737 cites W198146487 @default.
- W3206226737 cites W1985187618 @default.
- W3206226737 cites W1989255004 @default.
- W3206226737 cites W1992034786 @default.
- W3206226737 cites W2005924011 @default.
- W3206226737 cites W2007615143 @default.
- W3206226737 cites W2008160848 @default.
- W3206226737 cites W2009310911 @default.
- W3206226737 cites W2010004644 @default.
- W3206226737 cites W2012191523 @default.
- W3206226737 cites W2014193375 @default.
- W3206226737 cites W2015958583 @default.
- W3206226737 cites W2017539192 @default.
- W3206226737 cites W2018161340 @default.
- W3206226737 cites W2018494134 @default.
- W3206226737 cites W2028679380 @default.
- W3206226737 cites W2030809178 @default.
- W3206226737 cites W2031425506 @default.
- W3206226737 cites W2032279957 @default.
- W3206226737 cites W2033005687 @default.
- W3206226737 cites W2034183827 @default.
- W3206226737 cites W2042109117 @default.
- W3206226737 cites W2045773279 @default.
- W3206226737 cites W2046140971 @default.
- W3206226737 cites W2046298971 @default.
- W3206226737 cites W2048069737 @default.
- W3206226737 cites W2048928322 @default.
- W3206226737 cites W2051575984 @default.
- W3206226737 cites W2053232006 @default.
- W3206226737 cites W2056822207 @default.
- W3206226737 cites W2058563954 @default.
- W3206226737 cites W2060607069 @default.
- W3206226737 cites W2063186811 @default.
- W3206226737 cites W2064146504 @default.
- W3206226737 cites W2067090053 @default.
- W3206226737 cites W2067297934 @default.
- W3206226737 cites W2069345565 @default.
- W3206226737 cites W2075011812 @default.
- W3206226737 cites W2075182040 @default.
- W3206226737 cites W2076158259 @default.
- W3206226737 cites W2076958647 @default.
- W3206226737 cites W2079603513 @default.
- W3206226737 cites W2080204591 @default.
- W3206226737 cites W2088106697 @default.
- W3206226737 cites W2089494122 @default.
- W3206226737 cites W2091685079 @default.
- W3206226737 cites W2092381001 @default.
- W3206226737 cites W2094111986 @default.
- W3206226737 cites W2094327837 @default.
- W3206226737 cites W2097708776 @default.
- W3206226737 cites W2099363575 @default.
- W3206226737 cites W2105560295 @default.
- W3206226737 cites W2105743928 @default.
- W3206226737 cites W2107728559 @default.
- W3206226737 cites W2126091538 @default.
- W3206226737 cites W2126618271 @default.
- W3206226737 cites W2133226878 @default.
- W3206226737 cites W2133802104 @default.
- W3206226737 cites W2136715209 @default.
- W3206226737 cites W2142423474 @default.
- W3206226737 cites W2145136153 @default.
- W3206226737 cites W2145415920 @default.
- W3206226737 cites W2150071979 @default.
- W3206226737 cites W2151471589 @default.
- W3206226737 cites W2157019721 @default.
- W3206226737 cites W2157076733 @default.