Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206237788> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W3206237788 endingPage "176" @default.
- W3206237788 startingPage "171" @default.
- W3206237788 abstract "Background: Telomerase reverse-transcriptase (TERT) encodes the reverse transcriptase of telomerase, and TERT promoter mutations are enriched in advanced thyroid cancer. In this study, we aimed to characterize the clinicopathologic biology of differentiated thyroid cancer harboring TERT promoter mutations in Taiwan. Materials and Methods: Consecutive adult patients treated with differentiated thyroid cancer between 2017 and 2019 were included in this study. Mutational testing for the TERT promoter was performed by DNA-based polymerase chain reaction. Results: Among 389 patients included in the analysis, 22 (5.7%) had papillary or follicular thyroid cancer harboring TERT promoter mutations, including C228T (n = 18), C250T (n = 3), and CC242TT (n = 1). The frequency of BRAF V600E mutation was 73%. TERT promoter mutations were significantly associated with older age, tall cell variant of papillary thyroid cancer, extrathyroidal extension, positive surgical margins, lymphovascular invasion, perineural invasion, and distant metastasis. The generalized additive model showed that patient age was positively and almost linearly correlated with the likelihood of the presence of TERT promoter mutations. Conclusion: The frequency of TERT promoter mutations is relatively low in patients with differentiated thyroid cancer in Taiwan. These tumors carry unfavorable clinicopathologic features, present in a more advanced stage, and probably predict worse prognosis." @default.
- W3206237788 created "2021-10-25" @default.
- W3206237788 creator A5024242219 @default.
- W3206237788 creator A5066023719 @default.
- W3206237788 creator A5075960182 @default.
- W3206237788 date "2021-01-01" @default.
- W3206237788 modified "2023-09-25" @default.
- W3206237788 title "Significance of telomerase reverse-transcriptase promoter mutations in differentiated thyroid cancer" @default.
- W3206237788 cites W1995707208 @default.
- W3206237788 cites W2057308377 @default.
- W3206237788 cites W2064080521 @default.
- W3206237788 cites W2131117209 @default.
- W3206237788 cites W2145150141 @default.
- W3206237788 cites W2170217577 @default.
- W3206237788 cites W2170798594 @default.
- W3206237788 cites W2225849677 @default.
- W3206237788 cites W2738288615 @default.
- W3206237788 cites W2790272411 @default.
- W3206237788 cites W2795875131 @default.
- W3206237788 cites W2804007865 @default.
- W3206237788 cites W2887216539 @default.
- W3206237788 cites W2938226248 @default.
- W3206237788 cites W2966943425 @default.
- W3206237788 cites W2970571297 @default.
- W3206237788 cites W3010354368 @default.
- W3206237788 cites W3012062059 @default.
- W3206237788 cites W3016714823 @default.
- W3206237788 cites W3027716071 @default.
- W3206237788 cites W3035324574 @default.
- W3206237788 cites W3038544628 @default.
- W3206237788 cites W3042474997 @default.
- W3206237788 cites W3045694264 @default.
- W3206237788 cites W3092539041 @default.
- W3206237788 doi "https://doi.org/10.4103/fjs.fjs_212_20" @default.
- W3206237788 hasPublicationYear "2021" @default.
- W3206237788 type Work @default.
- W3206237788 sameAs 3206237788 @default.
- W3206237788 citedByCount "3" @default.
- W3206237788 countsByYear W32062377882022 @default.
- W3206237788 crossrefType "journal-article" @default.
- W3206237788 hasAuthorship W3206237788A5024242219 @default.
- W3206237788 hasAuthorship W3206237788A5066023719 @default.
- W3206237788 hasAuthorship W3206237788A5075960182 @default.
- W3206237788 hasBestOaLocation W32062377881 @default.
- W3206237788 hasConcept C104317684 @default.
- W3206237788 hasConcept C121608353 @default.
- W3206237788 hasConcept C125593758 @default.
- W3206237788 hasConcept C153911025 @default.
- W3206237788 hasConcept C156719811 @default.
- W3206237788 hasConcept C2779761222 @default.
- W3206237788 hasConcept C502942594 @default.
- W3206237788 hasConcept C54355233 @default.
- W3206237788 hasConcept C67705224 @default.
- W3206237788 hasConcept C71924100 @default.
- W3206237788 hasConcept C86803240 @default.
- W3206237788 hasConcept C94581717 @default.
- W3206237788 hasConceptScore W3206237788C104317684 @default.
- W3206237788 hasConceptScore W3206237788C121608353 @default.
- W3206237788 hasConceptScore W3206237788C125593758 @default.
- W3206237788 hasConceptScore W3206237788C153911025 @default.
- W3206237788 hasConceptScore W3206237788C156719811 @default.
- W3206237788 hasConceptScore W3206237788C2779761222 @default.
- W3206237788 hasConceptScore W3206237788C502942594 @default.
- W3206237788 hasConceptScore W3206237788C54355233 @default.
- W3206237788 hasConceptScore W3206237788C67705224 @default.
- W3206237788 hasConceptScore W3206237788C71924100 @default.
- W3206237788 hasConceptScore W3206237788C86803240 @default.
- W3206237788 hasConceptScore W3206237788C94581717 @default.
- W3206237788 hasIssue "5" @default.
- W3206237788 hasLocation W32062377881 @default.
- W3206237788 hasLocation W32062377882 @default.
- W3206237788 hasOpenAccess W3206237788 @default.
- W3206237788 hasPrimaryLocation W32062377881 @default.
- W3206237788 hasRelatedWork W1516186422 @default.
- W3206237788 hasRelatedWork W1563203286 @default.
- W3206237788 hasRelatedWork W1930583224 @default.
- W3206237788 hasRelatedWork W2312031035 @default.
- W3206237788 hasRelatedWork W2351761035 @default.
- W3206237788 hasRelatedWork W2354192789 @default.
- W3206237788 hasRelatedWork W2360988011 @default.
- W3206237788 hasRelatedWork W2373738424 @default.
- W3206237788 hasRelatedWork W2385881572 @default.
- W3206237788 hasRelatedWork W3206237788 @default.
- W3206237788 hasVolume "54" @default.
- W3206237788 isParatext "false" @default.
- W3206237788 isRetracted "false" @default.
- W3206237788 magId "3206237788" @default.
- W3206237788 workType "article" @default.