FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206285431> ?p ?o ?g. }

• W3206285431 abstract "<h3>Introduction/Background*</h3> Preoperative risk stratification of newly diagnosed endometrial carcinoma (EC) patients has been hindered by only moderate prediction performance for many years. Recently ENDORISK, a Bayesian network (BN) model using easily accessible biomarkers, showed increased predictive performance when compared to current guidelines. It was the aim of this study to validate ENDORISK by applying a locked-down model to a population-based case series of endometrial carcinoma patients. <h3>Methodology</h3> We assessed a retrospective cohort of women from the Tuebingen University Women’s Hospital surgically treated for EC from 2003-2013. Minimal requirements for using ENDORISK were: availability of preoperative tumour grade, at least 3 of ER, PR, p53 or L1CAM immunohistochemical biomarkers, at least 1 preoperative marker (PAP, CT-scan, CA125 or thrombocyte count), pathologic examination of lymph nodes, and 5-year disease specific survival data (DSS). ENDORISK was applied and prediction accuracy of lymph node metastasis (LNM) as well as 5-year DSS was investigated. The model’s overall performance was quantified by the Brier score, discriminative performance was measured based on the area under the curve. <h3>Result(s)*</h3> A complete data set was evaluable from 247 patients. Median patient age was 64yrs (33-90), 78.1% cases were endometrioid histotype. Grade distribution included 87 (35.2%) G1, 106 (42.9%) G2, and 54 (21.9%) G3 tumours. 156 (63.2%) patients had stage IA disease, with the remaining stage IB (n=52;21.1%), stage II (n=12;4.9%), and stage III/IV (n=27;10.9%). AUC for LNM prediction was 0.851 (95% confidence interval [CI] 0.761-0.941) and 0.698 (95% CI 0.595-0.800) for 5-year DSS. The Brier scores were 0.06 for LNM and 0.09 for 5-year DSS, respectively. In 156 patients (63.2%) LNM prediction was ≤ 5% (false-negative rate 0.6%). <h3>Conclusion*</h3> We have successfully demonstrated ENDORISK prediction of LNM and 5-year DSS in a large single-centre population-based cohort using preoperative clinical and biomarker data. Next steps will now have to focus on ENDORISK performance in clinical practice environments, e.g. dealing with missing data. Incorporating molecular profiling will be of key importance for future extended use. This external validation study reinforces previous findings and may support further promoting of data-based decision-making tools in EC research and patient care." @default.
• W3206285431 created "2021-10-25" @default.
• W3206285431 creator A5000405610 @default.
• W3206285431 creator A5008727204 @default.
• W3206285431 creator A5014642548 @default.
• W3206285431 creator A5028608453 @default.
• W3206285431 creator A5037433509 @default.
• W3206285431 creator A5037575440 @default.
• W3206285431 creator A5042235037 @default.
• W3206285431 creator A5045796936 @default.
• W3206285431 creator A5053276697 @default.
• W3206285431 creator A5056940578 @default.
• W3206285431 creator A5063215428 @default.
• W3206285431 creator A5069801250 @default.
• W3206285431 creator A5083376344 @default.
• W3206285431 date "2021-10-01" @default.
• W3206285431 modified "2023-09-26" @default.
• W3206285431 title "113 Improved preoperative risk stratification in endometrial cancer: External validation of the ENDORISK network model in a population-based case series" @default.
• W3206285431 doi "https://doi.org/10.1136/ijgc-2021-esgo.118" @default.
• W3206285431 hasPublicationYear "2021" @default.
• W3206285431 type Work @default.
• W3206285431 sameAs 3206285431 @default.
• W3206285431 citedByCount "0" @default.
• W3206285431 crossrefType "proceedings-article" @default.
• W3206285431 hasAuthorship W3206285431A5000405610 @default.
• W3206285431 hasAuthorship W3206285431A5008727204 @default.
• W3206285431 hasAuthorship W3206285431A5014642548 @default.
• W3206285431 hasAuthorship W3206285431A5028608453 @default.
• W3206285431 hasAuthorship W3206285431A5037433509 @default.
• W3206285431 hasAuthorship W3206285431A5037575440 @default.
• W3206285431 hasAuthorship W3206285431A5042235037 @default.
• W3206285431 hasAuthorship W3206285431A5045796936 @default.
• W3206285431 hasAuthorship W3206285431A5053276697 @default.
• W3206285431 hasAuthorship W3206285431A5056940578 @default.
• W3206285431 hasAuthorship W3206285431A5063215428 @default.
• W3206285431 hasAuthorship W3206285431A5069801250 @default.
• W3206285431 hasAuthorship W3206285431A5083376344 @default.
• W3206285431 hasBestOaLocation W32062854311 @default.
• W3206285431 hasConcept C119857082 @default.
• W3206285431 hasConcept C121608353 @default.
• W3206285431 hasConcept C126322002 @default.
• W3206285431 hasConcept C126838900 @default.
• W3206285431 hasConcept C143998085 @default.
• W3206285431 hasConcept C146357865 @default.
• W3206285431 hasConcept C151730666 @default.
• W3206285431 hasConcept C167135981 @default.
• W3206285431 hasConcept C2777088508 @default.
• W3206285431 hasConcept C2780824555 @default.
• W3206285431 hasConcept C2780849966 @default.
• W3206285431 hasConcept C2908647359 @default.
• W3206285431 hasConcept C35405484 @default.
• W3206285431 hasConcept C41008148 @default.
• W3206285431 hasConcept C71924100 @default.
• W3206285431 hasConcept C72563966 @default.
• W3206285431 hasConcept C86803240 @default.
• W3206285431 hasConcept C99454951 @default.
• W3206285431 hasConceptScore W3206285431C119857082 @default.
• W3206285431 hasConceptScore W3206285431C121608353 @default.
• W3206285431 hasConceptScore W3206285431C126322002 @default.
• W3206285431 hasConceptScore W3206285431C126838900 @default.
• W3206285431 hasConceptScore W3206285431C143998085 @default.
• W3206285431 hasConceptScore W3206285431C146357865 @default.
• W3206285431 hasConceptScore W3206285431C151730666 @default.
• W3206285431 hasConceptScore W3206285431C167135981 @default.
• W3206285431 hasConceptScore W3206285431C2777088508 @default.
• W3206285431 hasConceptScore W3206285431C2780824555 @default.
• W3206285431 hasConceptScore W3206285431C2780849966 @default.
• W3206285431 hasConceptScore W3206285431C2908647359 @default.
• W3206285431 hasConceptScore W3206285431C35405484 @default.
• W3206285431 hasConceptScore W3206285431C41008148 @default.
• W3206285431 hasConceptScore W3206285431C71924100 @default.
• W3206285431 hasConceptScore W3206285431C72563966 @default.
• W3206285431 hasConceptScore W3206285431C86803240 @default.
• W3206285431 hasConceptScore W3206285431C99454951 @default.
• W3206285431 hasLocation W32062854311 @default.
• W3206285431 hasOpenAccess W3206285431 @default.
• W3206285431 hasPrimaryLocation W32062854311 @default.
• W3206285431 hasRelatedWork W1985081679 @default.
• W3206285431 hasRelatedWork W2413926770 @default.
• W3206285431 hasRelatedWork W2574551019 @default.
• W3206285431 hasRelatedWork W2734526255 @default.
• W3206285431 hasRelatedWork W2947416310 @default.
• W3206285431 hasRelatedWork W3043972598 @default.
• W3206285431 hasRelatedWork W3166374797 @default.
• W3206285431 hasRelatedWork W3176047687 @default.
• W3206285431 hasRelatedWork W3211531481 @default.
• W3206285431 hasRelatedWork W2146615717 @default.
• W3206285431 isParatext "false" @default.
• W3206285431 isRetracted "false" @default.
• W3206285431 magId "3206285431" @default.
• W3206285431 workType "article" @default.