Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206291250> ?p ?o ?g. }
- W3206291250 endingPage "1674" @default.
- W3206291250 startingPage "1669" @default.
- W3206291250 abstract "The crystal structure of a 27-kilodalton methylcobalamin-containing fragment of methionine synthase from Escherichia coli was determined at 3.0 Å resolution. This structure depicts cobalamin-protein interactions and reveals that the corrin macrocycle lies between a helical amino-terminal domain and an α/β carboxyl-terminal domain that is a variant of the Rossmann fold. Methylcobalamin undergoes a conformational change on binding the protein; the dimethylbenzimidazole group, which is coordinated to the cobalt in the free cofactor, moves away from the corrin and is replaced by a histidine contributed by the protein. The sequence Asp-X-His-X-X-Gly, which contains this histidine ligand, is conserved in the adenosylcobalamin-dependent enzymes methylmalonyl-coenzyme A mutase and glutamate mutase, suggesting that displacement of the dimethylbenzimidazole will be a feature common to many cobalamin-binding proteins. Thus the cobalt ligand, His759, and the neighboring residues Asp757 and Ser810, may form a catalytic quartet, Co-His-Asp-Ser, that modulates the reactivity of the B12 prosthetic group in methionine synthase." @default.
- W3206291250 created "2021-10-25" @default.
- W3206291250 creator A5072228953 @default.
- W3206291250 date "1994-12-09" @default.
- W3206291250 modified "2023-10-16" @default.
- W3206291250 title "How a Protein Binds B<sub>12</sub>: A 3.0 Å X-Ray Structure of B<sub>12</sub>-Binding Domains of Methionine Synthase" @default.
- W3206291250 cites W1480861155 @default.
- W3206291250 cites W1535104931 @default.
- W3206291250 cites W1577530404 @default.
- W3206291250 cites W1606011614 @default.
- W3206291250 cites W1749026910 @default.
- W3206291250 cites W1950687899 @default.
- W3206291250 cites W1977231759 @default.
- W3206291250 cites W1978878503 @default.
- W3206291250 cites W1981708356 @default.
- W3206291250 cites W1982613368 @default.
- W3206291250 cites W1985255311 @default.
- W3206291250 cites W1986091806 @default.
- W3206291250 cites W1986647498 @default.
- W3206291250 cites W1989282758 @default.
- W3206291250 cites W1993404146 @default.
- W3206291250 cites W2002791277 @default.
- W3206291250 cites W2007677502 @default.
- W3206291250 cites W2008708467 @default.
- W3206291250 cites W2010729618 @default.
- W3206291250 cites W2013083986 @default.
- W3206291250 cites W2028231353 @default.
- W3206291250 cites W2030258806 @default.
- W3206291250 cites W2041537843 @default.
- W3206291250 cites W2044611444 @default.
- W3206291250 cites W204889168 @default.
- W3206291250 cites W2052434481 @default.
- W3206291250 cites W2052979701 @default.
- W3206291250 cites W2054538370 @default.
- W3206291250 cites W2058691613 @default.
- W3206291250 cites W2077469288 @default.
- W3206291250 cites W2082625715 @default.
- W3206291250 cites W2088816909 @default.
- W3206291250 cites W2091979836 @default.
- W3206291250 cites W2094180349 @default.
- W3206291250 cites W2095013747 @default.
- W3206291250 cites W2110049624 @default.
- W3206291250 cites W2129328760 @default.
- W3206291250 cites W2139848390 @default.
- W3206291250 cites W2142479284 @default.
- W3206291250 cites W2950752962 @default.
- W3206291250 cites W4293258013 @default.
- W3206291250 doi "https://doi.org/10.1126/science.7992050" @default.
- W3206291250 hasPublicationYear "1994" @default.
- W3206291250 type Work @default.
- W3206291250 sameAs 3206291250 @default.
- W3206291250 citedByCount "495" @default.
- W3206291250 countsByYear W32062912502012 @default.
- W3206291250 countsByYear W32062912502013 @default.
- W3206291250 countsByYear W32062912502014 @default.
- W3206291250 countsByYear W32062912502015 @default.
- W3206291250 countsByYear W32062912502016 @default.
- W3206291250 countsByYear W32062912502017 @default.
- W3206291250 countsByYear W32062912502018 @default.
- W3206291250 countsByYear W32062912502019 @default.
- W3206291250 countsByYear W32062912502020 @default.
- W3206291250 countsByYear W32062912502021 @default.
- W3206291250 countsByYear W32062912502022 @default.
- W3206291250 countsByYear W32062912502023 @default.
- W3206291250 crossrefType "journal-article" @default.
- W3206291250 hasAuthorship W3206291250A5072228953 @default.
- W3206291250 hasConcept C107824862 @default.
- W3206291250 hasConcept C116569031 @default.
- W3206291250 hasConcept C170493617 @default.
- W3206291250 hasConcept C181199279 @default.
- W3206291250 hasConcept C185592680 @default.
- W3206291250 hasConcept C197957613 @default.
- W3206291250 hasConcept C2777552656 @default.
- W3206291250 hasConcept C2778460671 @default.
- W3206291250 hasConcept C2778979354 @default.
- W3206291250 hasConcept C2779750884 @default.
- W3206291250 hasConcept C2779761754 @default.
- W3206291250 hasConcept C2780187287 @default.
- W3206291250 hasConcept C2780676250 @default.
- W3206291250 hasConcept C2780912031 @default.
- W3206291250 hasConcept C515207424 @default.
- W3206291250 hasConcept C55493867 @default.
- W3206291250 hasConcept C71240020 @default.
- W3206291250 hasConcept C8010536 @default.
- W3206291250 hasConcept C80315684 @default.
- W3206291250 hasConceptScore W3206291250C107824862 @default.
- W3206291250 hasConceptScore W3206291250C116569031 @default.
- W3206291250 hasConceptScore W3206291250C170493617 @default.
- W3206291250 hasConceptScore W3206291250C181199279 @default.
- W3206291250 hasConceptScore W3206291250C185592680 @default.
- W3206291250 hasConceptScore W3206291250C197957613 @default.
- W3206291250 hasConceptScore W3206291250C2777552656 @default.
- W3206291250 hasConceptScore W3206291250C2778460671 @default.
- W3206291250 hasConceptScore W3206291250C2778979354 @default.
- W3206291250 hasConceptScore W3206291250C2779750884 @default.
- W3206291250 hasConceptScore W3206291250C2779761754 @default.
- W3206291250 hasConceptScore W3206291250C2780187287 @default.
- W3206291250 hasConceptScore W3206291250C2780676250 @default.