FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206305280> ?p ?o ?g. }

• W3206305280 endingPage "1626" @default.
• W3206305280 startingPage "1626" @default.
• W3206305280 abstract "Cimicifugae Rhizoma has been used as a medicinal herb for fever, pain, and inflammation in East Asia. We conducted this study because the effect of Cimicifugae Rhizoma extract (CRE) on allergic asthma has not yet been evaluated. To induce allergic airway inflammation, we intraperitoneally injected ovalbumin (OVA) mixed with aluminum hydroxide into mice twice at intervals of 2 weeks (Days 0 and 14) and then inhaled them thrice with 1% OVA solution using a nebulizer (Days 21 to 23). CRE (30 and 100 mg/kg) was administered orally daily for 6 days (Days 18 to 23). The mice showed remarkable reduction in allergic inflammation at 100 mg/kg of CRE, as evidenced by decreased inflammatory cell counts, pro-inflammatory cytokine levels, OVA-specific immunoglobulin E level, airway hyperresponsiveness, and production of mucus. Additionally, these effects were involved with the enhancement of heme oxygenase-1 (HO-1), NAD(P)H: quinone oxidoreductase (NQO1), and nuclear factor erythroid 2-related factor 2 (Nrf2) expression and reduction of nuclear factor-κB (NF-κB) phosphorylation and matrix metalloproteinase-9 expression. Our findings indicated that CRE effectively protected against OVA-induced inflammation and oxidative stress via upregulation of the Nrf2/HO-1/NQO1 signaling and downregulation of NF-κB phosphorylation in asthma caused by OVA." @default.
• W3206305280 created "2021-10-25" @default.
• W3206305280 creator A5000814488 @default.
• W3206305280 creator A5007263146 @default.
• W3206305280 creator A5009660847 @default.
• W3206305280 creator A5015584163 @default.
• W3206305280 creator A5018435296 @default.
• W3206305280 creator A5035674745 @default.
• W3206305280 creator A5069885269 @default.
• W3206305280 creator A5070652882 @default.
• W3206305280 date "2021-10-15" @default.
• W3206305280 modified "2023-10-17" @default.
• W3206305280 title "Cimicifugae Rhizoma Extract Attenuates Oxidative Stress and Airway Inflammation via the Upregulation of Nrf2/HO-1/NQO1 and Downregulation of NF-κB Phosphorylation in Ovalbumin-Induced Asthma" @default.
• W3206305280 cites W1602409385 @default.
• W3206305280 cites W1822196508 @default.
• W3206305280 cites W1976871989 @default.
• W3206305280 cites W1984407952 @default.
• W3206305280 cites W2025242306 @default.
• W3206305280 cites W2045340028 @default.
• W3206305280 cites W2076934233 @default.
• W3206305280 cites W2078586397 @default.
• W3206305280 cites W2082624887 @default.
• W3206305280 cites W2087396447 @default.
• W3206305280 cites W2087975235 @default.
• W3206305280 cites W2132991001 @default.
• W3206305280 cites W2133781730 @default.
• W3206305280 cites W2135324209 @default.
• W3206305280 cites W2143341373 @default.
• W3206305280 cites W2161637575 @default.
• W3206305280 cites W2199624279 @default.
• W3206305280 cites W2746717617 @default.
• W3206305280 cites W2765365156 @default.
• W3206305280 cites W2884181644 @default.
• W3206305280 cites W2887622862 @default.
• W3206305280 cites W2905162294 @default.
• W3206305280 cites W2945857351 @default.
• W3206305280 cites W2948616744 @default.
• W3206305280 cites W2953342412 @default.
• W3206305280 cites W2980465010 @default.
• W3206305280 cites W2987172002 @default.
• W3206305280 cites W2991562785 @default.
• W3206305280 cites W2992544017 @default.
• W3206305280 cites W2995628819 @default.
• W3206305280 cites W2997521833 @default.
• W3206305280 cites W3000943734 @default.
• W3206305280 cites W3083440017 @default.
• W3206305280 cites W3107606304 @default.
• W3206305280 cites W871437046 @default.
• W3206305280 doi "https://doi.org/10.3390/antiox10101626" @default.
• W3206305280 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8533435" @default.
• W3206305280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34679759" @default.
• W3206305280 hasPublicationYear "2021" @default.
• W3206305280 type Work @default.
• W3206305280 sameAs 3206305280 @default.
• W3206305280 citedByCount "21" @default.
• W3206305280 countsByYear W32063052802022 @default.
• W3206305280 countsByYear W32063052802023 @default.
• W3206305280 crossrefType "journal-article" @default.
• W3206305280 hasAuthorship W3206305280A5000814488 @default.
• W3206305280 hasAuthorship W3206305280A5007263146 @default.
• W3206305280 hasAuthorship W3206305280A5009660847 @default.
• W3206305280 hasAuthorship W3206305280A5015584163 @default.
• W3206305280 hasAuthorship W3206305280A5018435296 @default.
• W3206305280 hasAuthorship W3206305280A5035674745 @default.
• W3206305280 hasAuthorship W3206305280A5069885269 @default.
• W3206305280 hasAuthorship W3206305280A5070652882 @default.
• W3206305280 hasBestOaLocation W32063052801 @default.
• W3206305280 hasConcept C104317684 @default.
• W3206305280 hasConcept C127561419 @default.
• W3206305280 hasConcept C134018914 @default.
• W3206305280 hasConcept C185592680 @default.
• W3206305280 hasConcept C203014093 @default.
• W3206305280 hasConcept C2776151105 @default.
• W3206305280 hasConcept C2776914184 @default.
• W3206305280 hasConcept C2776946954 @default.
• W3206305280 hasConcept C2779675166 @default.
• W3206305280 hasConcept C55493867 @default.
• W3206305280 hasConcept C71924100 @default.
• W3206305280 hasConcept C8891405 @default.
• W3206305280 hasConcept C98274493 @default.
• W3206305280 hasConceptScore W3206305280C104317684 @default.
• W3206305280 hasConceptScore W3206305280C127561419 @default.
• W3206305280 hasConceptScore W3206305280C134018914 @default.
• W3206305280 hasConceptScore W3206305280C185592680 @default.
• W3206305280 hasConceptScore W3206305280C203014093 @default.
• W3206305280 hasConceptScore W3206305280C2776151105 @default.
• W3206305280 hasConceptScore W3206305280C2776914184 @default.
• W3206305280 hasConceptScore W3206305280C2776946954 @default.
• W3206305280 hasConceptScore W3206305280C2779675166 @default.
• W3206305280 hasConceptScore W3206305280C55493867 @default.
• W3206305280 hasConceptScore W3206305280C71924100 @default.
• W3206305280 hasConceptScore W3206305280C8891405 @default.
• W3206305280 hasConceptScore W3206305280C98274493 @default.
• W3206305280 hasIssue "10" @default.
• W3206305280 hasLocation W32063052801 @default.
• W3206305280 hasLocation W32063052802 @default.
• W3206305280 hasLocation W32063052803 @default.
• W3206305280 hasOpenAccess W3206305280 @default.

• next