FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206316297> ?p ?o ?g. }

• W3206316297 abstract "While a large body of literature documents the impairing effect of anxiety on cognition, performing a demanding task was shown to be effective in reducing anxiety. Here we explored the mechanisms of this anxiolytic effect by examining how a pharmacological challenge designed to improve attentional processes influences the interplay between the neural networks engaged during anxiety and cognition. Using a double-blind between-subject design, we pharmacologically manipulated working memory (WM) using a single oral dose of 20 mg methylphenidate (MPH, cognitive enhancer) or placebo. Fifty healthy adults (25/drug group) performed two runs of a WM N-back task in a 3 T magnetic resonance imaging scanner. This task comprised a low (1-Back) and high (3-Back) WM load, which were performed in two contexts, safety or threat of shocks (induced-anxiety). Analyses revealed that (1) WM accuracy was overall improved by MPH and (2) MPH (vs. placebo) strengthened the engagement of regions within the fronto-parietal control network (FPCN) and reduced the default mode network (DMN) deactivation. These MPH effects predominated in the most difficult context, i.e., threat condition, first run (novelty of the task), and 3-Back task. The facilitation of neural activation can be interpreted as an expansion of cognitive resources, which could foster both the representation and integration of anxiety-provoking stimuli as well as the top-down regulatory processes to protect against the detrimental effect of anxiety. This mechanism might establish an optimal balance between FPCN (cognitive processing) and DMN (emotion regulation) recruitment." @default.
• W3206316297 created "2021-10-25" @default.
• W3206316297 creator A5009835857 @default.
• W3206316297 creator A5012255878 @default.
• W3206316297 creator A5016019834 @default.
• W3206316297 creator A5025001284 @default.
• W3206316297 creator A5057718054 @default.
• W3206316297 creator A5064418543 @default.
• W3206316297 creator A5072137399 @default.
• W3206316297 creator A5074496772 @default.
• W3206316297 date "2021-10-21" @default.
• W3206316297 modified "2023-09-27" @default.
• W3206316297 title "Methylphenidate modulates interactions of anxiety with cognition" @default.
• W3206316297 cites W1802062438 @default.
• W3206316297 cites W1857778287 @default.
• W3206316297 cites W1951724000 @default.
• W3206316297 cites W1970695058 @default.
• W3206316297 cites W1985472839 @default.
• W3206316297 cites W1999610178 @default.
• W3206316297 cites W2000697043 @default.
• W3206316297 cites W2012903868 @default.
• W3206316297 cites W2012989506 @default.
• W3206316297 cites W2019778434 @default.
• W3206316297 cites W2020745232 @default.
• W3206316297 cites W2025009638 @default.
• W3206316297 cites W2027473195 @default.
• W3206316297 cites W2035465204 @default.
• W3206316297 cites W2044465819 @default.
• W3206316297 cites W2048890179 @default.
• W3206316297 cites W2054777821 @default.
• W3206316297 cites W2066821961 @default.
• W3206316297 cites W2068673705 @default.
• W3206316297 cites W2073330852 @default.
• W3206316297 cites W2099355488 @default.
• W3206316297 cites W2103100551 @default.
• W3206316297 cites W2107217609 @default.
• W3206316297 cites W2111603698 @default.
• W3206316297 cites W2117140276 @default.
• W3206316297 cites W2120251526 @default.
• W3206316297 cites W2122538041 @default.
• W3206316297 cites W2124607005 @default.
• W3206316297 cites W2129574992 @default.
• W3206316297 cites W2132023469 @default.
• W3206316297 cites W2132720746 @default.
• W3206316297 cites W2134864987 @default.
• W3206316297 cites W2137725373 @default.
• W3206316297 cites W2142360036 @default.
• W3206316297 cites W2142999685 @default.
• W3206316297 cites W2143114368 @default.
• W3206316297 cites W2144093039 @default.
• W3206316297 cites W2144427015 @default.
• W3206316297 cites W2152929067 @default.
• W3206316297 cites W2157840419 @default.
• W3206316297 cites W2170595219 @default.
• W3206316297 cites W2177636133 @default.
• W3206316297 cites W2293089587 @default.
• W3206316297 cites W2298269150 @default.
• W3206316297 cites W2342839846 @default.
• W3206316297 cites W2497408329 @default.
• W3206316297 cites W2497879554 @default.
• W3206316297 cites W2588860206 @default.
• W3206316297 cites W2900917761 @default.
• W3206316297 cites W2905880573 @default.
• W3206316297 cites W2952168991 @default.
• W3206316297 cites W3049285873 @default.
• W3206316297 cites W4213346165 @default.
• W3206316297 cites W4251941333 @default.
• W3206316297 doi "https://doi.org/10.1038/s41398-021-01621-2" @default.
• W3206316297 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8531440" @default.
• W3206316297 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34675189" @default.
• W3206316297 hasPublicationYear "2021" @default.
• W3206316297 type Work @default.
• W3206316297 sameAs 3206316297 @default.
• W3206316297 citedByCount "3" @default.
• W3206316297 countsByYear W32063162972022 @default.
• W3206316297 countsByYear W32063162972023 @default.
• W3206316297 crossrefType "journal-article" @default.
• W3206316297 hasAuthorship W3206316297A5009835857 @default.
• W3206316297 hasAuthorship W3206316297A5012255878 @default.
• W3206316297 hasAuthorship W3206316297A5016019834 @default.
• W3206316297 hasAuthorship W3206316297A5025001284 @default.
• W3206316297 hasAuthorship W3206316297A5057718054 @default.
• W3206316297 hasAuthorship W3206316297A5064418543 @default.
• W3206316297 hasAuthorship W3206316297A5072137399 @default.
• W3206316297 hasAuthorship W3206316297A5074496772 @default.
• W3206316297 hasBestOaLocation W32063162971 @default.
• W3206316297 hasConcept C118552586 @default.
• W3206316297 hasConcept C141516989 @default.
• W3206316297 hasConcept C151730666 @default.
• W3206316297 hasConcept C15744967 @default.
• W3206316297 hasConcept C169760540 @default.
• W3206316297 hasConcept C169900460 @default.
• W3206316297 hasConcept C180747234 @default.
• W3206316297 hasConcept C21963081 @default.
• W3206316297 hasConcept C2777112843 @default.
• W3206316297 hasConcept C2779226451 @default.
• W3206316297 hasConcept C2779343474 @default.
• W3206316297 hasConcept C2780783007 @default.
• W3206316297 hasConcept C548259974 @default.
• W3206316297 hasConcept C558461103 @default.

• next