FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206333480> ?p ?o ?g. }

• W3206333480 endingPage "146007" @default.
• W3206333480 startingPage "146007" @default.
• W3206333480 abstract "The purpose of this study was to investigate the effect of CYP3A7, CYP3A4, and CYP3A5 genetic polymorphisms in liver transplant recipients and donors on tacrolimus concentrations in the early stages after liver transplantation.One hundred and thirty-eight liver transplant recipients and matched donors were genotyped for CYP3A7 (rs10211 and rs2257401), CYP3A4 (rs4646437 and rs2242480), and CYP3A5*3 (rs776746) polymorphisms. The relationships between dose-adjusted trough concentrations (C0/D) of tacrolimus and corresponding genotypes were investigated.Recipient CYP3A polymorphisms were associated with tacrolimus concentrations. The CYP3A7 rs10211 AA carriers (186.2 vs 90.5, p < 0.001), CYP3A4 rs4646437 CC carriers (184.0 vs 88.8, p < 0.001), CYP3A4*1G rs2242480 CC carriers (189.8 vs 99.7, p < 0.001), and CYP3A5*3 rs776746 GG carriers (197.3 vs 86.0, p < 0.001) had an almost twofold increase in the tacrolimus C0/D compared to that of the non-carriers. We further investigated the effect of the combination of recipient (intestinal) and donor (hepatic) genotypes on tacrolimus concentrations. Regardless of the genotype of the matched donor, CYP3A7 rs10211, CYP3A4*1G (rs2242480), and CYP3A5*3 (rs776746) polymorphisms of recipients could affect tacrolimus concentrations. For the CYP3A4 rs4646437 polymorphisms, when the donor carried CYP3A4 rs4646437 CC, the recipient CYP3A4 rs4646437 polymorphism was associated with the C0/D of tacrolimus, and when the donor carried CYP3A4 rs4646437 CT/TT genotype, the recipient CYP3A4 rs4646437 polymorphism also affected on tacrolimus C0/D, although the effect was not significant.The large inter-individual variation in tacrolimus concentrations in the early stages after liver transplantation is influenced by genetic polymorphisms of CYP3A7, CYP3A4, and CYP3A5. Recipient (intestinal) CYP3A7, CYP3A4, and CYP3A5 polymorphisms seem to contribute more to such variation than donors. Therefore, the detection of CYP3A polymorphisms in recipients could help to predict the tacrolimus starting dose in the early stages after liver transplantation." @default.
• W3206333480 created "2021-10-25" @default.
• W3206333480 creator A5013017488 @default.
• W3206333480 creator A5032379172 @default.
• W3206333480 creator A5034544317 @default.
• W3206333480 creator A5038349950 @default.
• W3206333480 creator A5046380471 @default.
• W3206333480 creator A5048119294 @default.
• W3206333480 creator A5049390648 @default.
• W3206333480 creator A5050208449 @default.
• W3206333480 creator A5059844255 @default.
• W3206333480 creator A5081946864 @default.
• W3206333480 creator A5091594797 @default.
• W3206333480 date "2022-01-01" @default.
• W3206333480 modified "2023-10-16" @default.
• W3206333480 title "CYP3A7, CYP3A4, and CYP3A5 genetic polymorphisms in recipients rather than donors influence tacrolimus concentrations in the early stages after liver transplantation" @default.
• W3206333480 cites W1882474387 @default.
• W3206333480 cites W1913100467 @default.
• W3206333480 cites W1964908406 @default.
• W3206333480 cites W1989000004 @default.
• W3206333480 cites W1994029494 @default.
• W3206333480 cites W2007469043 @default.
• W3206333480 cites W2011043888 @default.
• W3206333480 cites W2027774666 @default.
• W3206333480 cites W2033139608 @default.
• W3206333480 cites W2034424913 @default.
• W3206333480 cites W2035276049 @default.
• W3206333480 cites W2036807791 @default.
• W3206333480 cites W2039192679 @default.
• W3206333480 cites W2045923686 @default.
• W3206333480 cites W2061945577 @default.
• W3206333480 cites W2064883756 @default.
• W3206333480 cites W2080228333 @default.
• W3206333480 cites W2088250393 @default.
• W3206333480 cites W2089892642 @default.
• W3206333480 cites W2095454634 @default.
• W3206333480 cites W2097675898 @default.
• W3206333480 cites W2105902511 @default.
• W3206333480 cites W2109380210 @default.
• W3206333480 cites W2115061192 @default.
• W3206333480 cites W2126772533 @default.
• W3206333480 cites W2130106335 @default.
• W3206333480 cites W2516309500 @default.
• W3206333480 cites W2581036173 @default.
• W3206333480 cites W2758238650 @default.
• W3206333480 cites W2776638930 @default.
• W3206333480 cites W2906028817 @default.
• W3206333480 cites W2926347017 @default.
• W3206333480 cites W2936944085 @default.
• W3206333480 cites W2942673049 @default.
• W3206333480 cites W2953274239 @default.
• W3206333480 cites W2968645237 @default.
• W3206333480 cites W3013675935 @default.
• W3206333480 cites W4292958705 @default.
• W3206333480 cites W850981696 @default.
• W3206333480 doi "https://doi.org/10.1016/j.gene.2021.146007" @default.
• W3206333480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34688813" @default.
• W3206333480 hasPublicationYear "2022" @default.
• W3206333480 type Work @default.
• W3206333480 sameAs 3206333480 @default.
• W3206333480 citedByCount "10" @default.
• W3206333480 countsByYear W32063334802021 @default.
• W3206333480 countsByYear W32063334802022 @default.
• W3206333480 countsByYear W32063334802023 @default.
• W3206333480 crossrefType "journal-article" @default.
• W3206333480 hasAuthorship W3206333480A5013017488 @default.
• W3206333480 hasAuthorship W3206333480A5032379172 @default.
• W3206333480 hasAuthorship W3206333480A5034544317 @default.
• W3206333480 hasAuthorship W3206333480A5038349950 @default.
• W3206333480 hasAuthorship W3206333480A5046380471 @default.
• W3206333480 hasAuthorship W3206333480A5048119294 @default.
• W3206333480 hasAuthorship W3206333480A5049390648 @default.
• W3206333480 hasAuthorship W3206333480A5050208449 @default.
• W3206333480 hasAuthorship W3206333480A5059844255 @default.
• W3206333480 hasAuthorship W3206333480A5081946864 @default.
• W3206333480 hasAuthorship W3206333480A5091594797 @default.
• W3206333480 hasConcept C104317684 @default.
• W3206333480 hasConcept C109650736 @default.
• W3206333480 hasConcept C11824378 @default.
• W3206333480 hasConcept C126322002 @default.
• W3206333480 hasConcept C134018914 @default.
• W3206333480 hasConcept C135763542 @default.
• W3206333480 hasConcept C2779609443 @default.
• W3206333480 hasConcept C2909675724 @default.
• W3206333480 hasConcept C2911091166 @default.
• W3206333480 hasConcept C526171541 @default.
• W3206333480 hasConcept C54355233 @default.
• W3206333480 hasConcept C62231903 @default.
• W3206333480 hasConcept C71924100 @default.
• W3206333480 hasConcept C86803240 @default.
• W3206333480 hasConcept C90924648 @default.
• W3206333480 hasConcept C92137452 @default.
• W3206333480 hasConceptScore W3206333480C104317684 @default.
• W3206333480 hasConceptScore W3206333480C109650736 @default.
• W3206333480 hasConceptScore W3206333480C11824378 @default.
• W3206333480 hasConceptScore W3206333480C126322002 @default.
• W3206333480 hasConceptScore W3206333480C134018914 @default.
• W3206333480 hasConceptScore W3206333480C135763542 @default.

• next